KEGG   Cryptosporidium hominis: Chro.40506Help
Entry
Chro.40506        CDS       T00210                                 

Definition
chain A, crystal structure of Dhfr
Orthology
K13998  
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
cho  Cryptosporidium hominis
Pathway
Pyrimidine metabolism
One carbon pool by folate
Folate biosynthesis
Metabolic pathways
Brite
KEGG Orthology (KO) [BR:cho00001]
 Metabolism
  Nucleotide metabolism
   00240 Pyrimidine metabolism
    Chro.40506
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    Chro.40506
   00670 One carbon pool by folate
    Chro.40506
Enzymes [BR:cho01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     Chro.40506
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     Chro.40506
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Structure
PDB: 

Jmol
Position
4
AA seq 521 aa AA seqDB search
MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWD
SIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYR
DALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEK
KTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQY
LDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK
GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDY
TGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNL
YQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRT
PRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV
NT seq 1566 nt NT seq  +upstreamnt  +downstreamnt
atgagtgaaaagaacgtttcaattgttgtggcagcttctgttttgagcagtgggatagga
attaacggacaattaccttggtctatatctgaggatttgaaatttttttcaaagataact
aataataaatgtgactcgaataagaagaatgcactaattatgggaagaaaaacatgggat
tcaattggaagaagacctcttaaaaatagaataattgtcgttatttcctccagcttacca
caagatgaagccgatcctaatgttgttgtatttagaaaccttgaagactcaatagagaat
cttatgaatgatgactcaattgagaatattttcgtctgtggtggtgaatccatatacagg
gatgctttaaaggataactttgtagatagaatatacttaacaagggtggcactagaagat
atagaatttgacacttatttcccagaaatacctgagacattcttaccagtatatatgtct
cagacattctgtactaagaatatctcttatgattttatgatttttgaaaaacaagaaaaa
aaaactttacaaaattgtgaccctgccagaggtcaattaaagtccattgatgatacagtt
gatcttcttggtgaaatatttgggattagaaaaatgggaaatagacacaagtttccaaaa
gaagaaatctacaacactccaagtattcgattcggaagagaacattatgagtttcagtac
ctggaccttctttctagggtcttagagaatggagcttatagggaaaataggacaggcatt
agtacatattcaatatttggtcagatgatgagatttgatatgagagaatcttttccactt
ttgactacaaaaaaagttgcaatcagatccatttttgaggagttaatatggtttattaag
ggagatactaatggaaatcatttgattgagaaaaaagtttatatttggtcaggaaatggc
tcgaaagaatatttggaaagaattggtttagggcatagagaggagaatgatttgggcccg
atctatggttttcagtggagacattacaatggagagtacaaaacgatgcatgacgattat
accggagttggagttgatcagcttgcaaaacttattgagaccctaaagaataacccaaag
gatagaaggcatatactaacagcctggaatccatctgccctatctcaaatggctcttccg
ccttgccatgtgctttctcagtattatgttaccaatgataattgtcttagttgcaacctt
tatcaaaggagttgtgacttgggattaggatctccatttaacattgcatcttatgctata
cttaccatgatgcttgctcaagtttgtggttatgaaccaggtgagcttgctatttttatt
ggagatgcccatatctatgaaaatcacctaacacaattaaaagaacaattaagccgcact
ccacgtccatttccacaactcaaattcaaaagaaaagttgaaaatattgaagactttaaa
tgggaagacatcgaattaatcggatattatccatatcccactattaaaatggacatggcg
gtataa

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