Database: COMPOUNDEntry: C02210 C11684 C16041 C16042 C16043 C15890 C15891 C01574 C16135 C01516
LinkDB: C02210 C11684 C16041 C16042 C16043 C15890 C15891 C01574 C16135 C01516
ENTRY C02210 Peptide Compound
NAME beta-Endorphin
SEQUENCE Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr
Leu Phe Lys Asn Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu
ORGANISM Human [HSA:5443] [UP:COLI_HUMAN]
COMMENT Opioid peptides
Target: mu-opioid receptor agonist [HSA:4988] [PATH:hsa04080], delta-opioid receptor agonist [HSA:4985] [PATH:hsa04080]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
ko04915 Estrogen signaling pathway
BRITE Bioactive peptides [BR:br08005]
Pituitary hormones
Proopiomelanocortin-derived peptide
C02210 Endorphin beta
DBLINKS CAS: 60617-12-1
PubChem: 5278
ChEBI: 10415
NIKKAJI: J39.450E
///
ENTRY C11684 Peptide Compound
NAME MET-enkephalin;
Methionine enkephalin
FORMULA C27H35N5O7S
EXACT_MASS 573.2257
MOL_WEIGHT 573.6611
SEQUENCE Tyr Gly Gly Phe Met
ORGANISM Human [HSA:5179] [UP:PENK_HUMAN]
COMMENT opioid peptide
Target: delta-opioid receptor agonist [HSA:4985] [KO:K04213], mu-opioid receptor agonist [HSA:4988] [KO:K04215]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C11684 Met-enkephalin
DBLINKS CAS: 58569-55-4
PubChem: 13849
NIKKAJI: J246.108K
ATOM 40
1 C8x C 17.2009 -20.4310
2 C8y C 15.9810 -19.7318
3 C8x C 15.9783 -18.3358
4 C8x C 17.1916 -17.6278
5 C8y C 18.4128 -18.3357
6 C8x C 18.4122 -19.7390
7 O1a O 14.7710 -20.4385
8 C1b C 19.6280 -17.6378
9 C1c C 19.6272 -16.2396
10 N1a N 18.4130 -15.5380
11 C5a C 20.8341 -15.5399
12 N1b N 22.0460 -16.2374
13 C1b C 23.2578 -15.5328
14 C5a C 24.4698 -16.2303
15 N1b N 25.6746 -15.5257
16 C1b C 26.8866 -16.2234
17 C5a C 28.0984 -15.5188
18 N1b N 29.3103 -16.2163
19 C1c C 30.5223 -15.5117
20 C5a C 31.7341 -16.2092
21 N1b N 32.9460 -15.5045
22 C1c C 34.1580 -16.2023
23 C6a C 35.3628 -15.4976
24 O5a O 20.8310 -14.1379
25 O5a O 24.4728 -17.6325
26 O5a O 28.0953 -14.1167
27 C1b C 30.5192 -14.1096
28 C8y C 31.7329 -13.4094
29 C8x C 32.9457 -14.1061
30 C8x C 34.1587 -13.4070
31 C8x C 34.1563 -12.0033
32 C8x C 32.9310 -11.3017
33 C8x C 31.7231 -12.0117
34 O5a O 31.7371 -17.6114
35 C1b C 34.1629 -17.5974
36 C1b C 32.9570 -18.2991
37 S2a S 32.9617 -19.6942
38 C1a C 31.7560 -20.3958
39 O6a O 36.5746 -16.1887
40 O6a O 35.3542 -14.1018
BOND 41
1 5 8 1
2 9 8 1 #Down
3 4 5 1
4 2 3 1
5 5 6 2
6 19 20 1
7 20 21 1
8 21 22 1
9 22 23 1
10 11 12 1
11 12 13 1
12 11 24 2
13 13 14 1
14 14 25 2
15 17 26 2
16 14 15 1
17 19 27 1 #Up
18 15 16 1
19 27 28 1
20 28 29 2
21 16 17 1
22 29 30 1
23 30 31 2
24 17 18 1
25 31 32 1
26 32 33 2
27 33 28 1
28 18 19 1
29 20 34 2
30 11 9 1
31 22 35 1 #Down
32 9 10 1
33 35 36 1
34 6 1 1
35 36 37 1
36 1 2 2
37 37 38 1
38 2 7 1
39 3 4 2
40 23 39 1
41 23 40 2
///
ENTRY C16041 Peptide Compound
NAME Leu-enkephalin
SEQUENCE Tyr Gly Gly Phe Leu
ORGANISM Human [HSA:5179] [UP:PENK_HUMAN PDYN_HUMAN]
COMMENT opioid peptide
Target: delta-opioid receptor agonist [HSA:4985] [KO:K04213], mu-opioid receptor angonist [HSA:4988] [KO:K04215]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
ko04721 Synaptic vesicle cycle
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16041 Leu-enkephalin
DBLINKS PubChem: 47205351
NIKKAJI: J247.065I
///
ENTRY C16042 Peptide Compound
NAME Met-enkephalin-Arg-Gly-Leu
SEQUENCE Tyr Gly Gly Phe Met Arg Gly Leu
ORGANISM Human [HSA:5179] [UP:PENK_HUMAN]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16042 Met-enkephalin-Arg-Gly-Leu
DBLINKS PubChem: 47205352
NIKKAJI: J374.467A
///
ENTRY C16043 Peptide Compound
NAME Met-enkephalin-Arg-Phe
SEQUENCE Tyr Gly Gly Phe Met Arg Phe
ORGANISM Human [HSA:5179] [UP:PENK_HUMAN]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16043 Met-enkephalin-Arg-Phe
DBLINKS PubChem: 47205353
NIKKAJI: J374.466C
///
ENTRY C15890 Peptide Compound
NAME Endomorphin-1
SEQUENCE Tyr Pro Trp Phe-NH2
COMMENT mu-opioid receptor agonist [HSA:4988] [PATH:hsa04080]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C15890 Endomorphin-1
DBLINKS PubChem: 47205210
NIKKAJI: J830.103D
///
ENTRY C15891 Peptide Compound
NAME Endomorphin-2
SEQUENCE Tyr Pro Phe Phe-NH2
COMMENT mu-opioid receptor agonist [HSA:4988] [PATH:hsa04080]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C15891 Endomorphin-2
DBLINKS PubChem: 47205211
NIKKAJI: J454.979A
///
ENTRY C01574 Peptide Compound
NAME Dynorphin;
Dynorphin A
SEQUENCE Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn
Gln
ORGANISM Human [HSA:5173] [UP:PDYN_HUMAN]
COMMENT opioid peptide
Target: kappa-opioid receptor agonist [HSA:4986] [PATH:hsa04080], mu-opioid receptor agonist [HSA:4988] [PATH:hsa04080]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C01574 Dynorphin A
DBLINKS CAS: 74913-18-1
PubChem: 4731
///
ENTRY C16135 Peptide Compound
NAME Dynorphin B;
Rimorphin
SEQUENCE Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr
ORGANISM Human [HSA:5173] [UP:PDYN_HUMAN]
COMMENT opioid peptide
Target: kappa-opioid receptor agonist [HSA:4986] [PATH:hsa04080]
PATHWAY ko04080 Neuroactive ligand-receptor interaction
BRITE Bioactive peptides [BR:br08005]
Neuropeptides
Endogenous opioid peptide
C16135 Dynorphin B
DBLINKS CAS: 83335-41-5
PubChem: 47205445
NIKKAJI: J39.439D
///
ENTRY C01516 Compound
NAME Morphine
FORMULA C17H19NO3
EXACT_MASS 285.1365
MOL_WEIGHT 285.3377
REMARK Same as: D08233
COMMENT Source: Papaver somniferum [TAX:3469]
opium alkaloid
REACTION R03591 R03592 R03697 R08262 R08263 R08265 R09402
PATHWAY ko00950 Isoquinoline alkaloid biosynthesis
ko00982 Drug metabolism - cytochrome P450
map01063 Biosynthesis of alkaloids derived from shikimate pathway
ko01100 Metabolic pathways
ko01110 Biosynthesis of secondary metabolites
ko04080 Neuroactive ligand-receptor interaction
ENZYME 1.1.1.218 1.14.11.32 1.14.14.1 2.4.1.17
BRITE Compounds with biological roles [BR:br08001]
Phytochemical compounds
Alkaloids
C01516 Morphine
Phytochemical compounds [BR:br08003]
Alkaloids
Alkaloids derived from tyrosine
Isoquinoline alkaloids
C01516 Morphine
DBLINKS CAS: 57-27-2
PubChem: 4681
ChEBI: 17303
KNApSAcK: C00001889
PDB-CCD: MOI
3DMET: B04801
NIKKAJI: J2.323J
ATOM 21
1 C1z C 21.5384 -23.5506
2 C8y C 21.5384 -22.2288
3 C1y C 22.7210 -24.2462
4 C1y C 20.4253 -24.1767
5 C1x C 22.7210 -22.9245
6 C8y C 20.4253 -21.6027
7 C8y C 22.7210 -21.6027
8 C1y C 23.8341 -23.5506
9 C2x C 22.7210 -25.4984
10 O2x O 19.1036 -22.8548
11 C1y C 20.4253 -25.4984
12 C1x C 24.9471 -22.9245
13 C8y C 20.4253 -20.2809
14 C1x C 23.8341 -22.2983
15 C8x C 22.7210 -20.2809
16 N1y N 24.9471 -24.2462
17 C2x C 21.5384 -26.1941
18 O1a O 19.3123 -26.1941
19 C8x C 21.6080 -19.6549
20 O1a O 19.3123 -19.6549
21 C1a C 26.3437 -24.2462
BOND 25
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 1 #Down
10 4 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 8 16 1 #Up
16 9 17 2
17 11 18 1 #Down
18 13 19 2
19 13 20 1
20 6 10 1
21 8 14 1
22 11 17 1
23 12 16 1
24 15 19 1
25 16 21 1
///
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