GenomeNet

Database: COMPOUND
Entry: C02210 C11684 C16041 C16042 C16043 C15890 C15891 C01574 C16135 C01516
LinkDB: C02210 C11684 C16041 C16042 C16043 C15890 C15891 C01574 C16135 C01516
ENTRY       C02210            Peptide   Compound
NAME        beta-Endorphin
SEQUENCE    Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr
            Leu Phe Lys Asn Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu
  ORGANISM  Human [HSA:5443] [UP:COLI_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
            map04915  Estrogen signaling pathway
BRITE       Bioactive peptides [BR:br08005]
             Pituitary hormones
              Proopiomelanocortin-derived peptide
               C02210  Endorphin beta
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                delta-opioid receptor
                 C02210  beta-Endorphin
                mu-opioid receptor
                 C02210  beta-Endorphin
DBLINKS     CAS: 60617-12-1
            PubChem: 5278
            ChEBI: 10415
            NIKKAJI: J39.450E
///
ENTRY       C11684            Peptide   Compound
NAME        MET-enkephalin;
            Methionine enkephalin
FORMULA     C27H35N5O7S
EXACT_MASS  573.2257
MOL_WEIGHT  573.6611



SEQUENCE    Tyr Gly Gly Phe Met
  ORGANISM  Human [HSA:5179] [UP:PENK_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C11684  Met-enkephalin
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                delta-opioid receptor
                 C11684  Met-enkephalin
                mu-opioid receptor
                 C11684  MET-enkephalin
DBLINKS     CAS: 58569-55-4
            PubChem: 13849
            NIKKAJI: J246.108K
ATOM        40
            1   C8x C    17.2009  -20.4310
            2   C8y C    15.9810  -19.7318
            3   C8x C    15.9783  -18.3358
            4   C8x C    17.1916  -17.6278
            5   C8y C    18.4128  -18.3357
            6   C8x C    18.4122  -19.7390
            7   O1a O    14.7710  -20.4385
            8   C1b C    19.6280  -17.6378
            9   C1c C    19.6272  -16.2396
            10  N1a N    18.4130  -15.5380
            11  C5a C    20.8341  -15.5399
            12  N1b N    22.0460  -16.2374
            13  C1b C    23.2578  -15.5328
            14  C5a C    24.4698  -16.2303
            15  N1b N    25.6746  -15.5257
            16  C1b C    26.8866  -16.2234
            17  C5a C    28.0984  -15.5188
            18  N1b N    29.3103  -16.2163
            19  C1c C    30.5223  -15.5117
            20  C5a C    31.7341  -16.2092
            21  N1b N    32.9460  -15.5045
            22  C1c C    34.1580  -16.2023
            23  C6a C    35.3628  -15.4976
            24  O5a O    20.8310  -14.1379
            25  O5a O    24.4728  -17.6325
            26  O5a O    28.0953  -14.1167
            27  C1b C    30.5192  -14.1096
            28  C8y C    31.7329  -13.4094
            29  C8x C    32.9457  -14.1061
            30  C8x C    34.1587  -13.4070
            31  C8x C    34.1563  -12.0033
            32  C8x C    32.9310  -11.3017
            33  C8x C    31.7231  -12.0117
            34  O5a O    31.7371  -17.6114
            35  C1b C    34.1629  -17.5974
            36  C1b C    32.9570  -18.2991
            37  S2a S    32.9617  -19.6942
            38  C1a C    31.7560  -20.3958
            39  O6a O    36.5746  -16.1887
            40  O6a O    35.3542  -14.1018
BOND        41
            1     5   8 1
            2     9   8 1 #Down
            3     4   5 1
            4     2   3 1
            5     5   6 2
            6    19  20 1
            7    20  21 1
            8    21  22 1
            9    22  23 1
            10   11  12 1
            11   12  13 1
            12   11  24 2
            13   13  14 1
            14   14  25 2
            15   17  26 2
            16   14  15 1
            17   19  27 1 #Up
            18   15  16 1
            19   27  28 1
            20   28  29 2
            21   16  17 1
            22   29  30 1
            23   30  31 2
            24   17  18 1
            25   31  32 1
            26   32  33 2
            27   33  28 1
            28   18  19 1
            29   20  34 2
            30   11   9 1
            31   22  35 1 #Down
            32    9  10 1
            33   35  36 1
            34    6   1 1
            35   36  37 1
            36    1   2 2
            37   37  38 1
            38    2   7 1
            39    3   4 2
            40   23  39 1
            41   23  40 2
///
ENTRY       C16041            Peptide   Compound
NAME        Leu-enkephalin
SEQUENCE    Tyr Gly Gly Phe Leu
  ORGANISM  Human [HSA:5179] [UP:PENK_HUMAN PDYN_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
            map04721  Synaptic vesicle cycle
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C16041  Leu-enkephalin
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                delta-opioid receptor
                 C16041  Leu-enkephalin
                mu-opioid receptor
                 C16041  Leu-enkephalin
DBLINKS     PubChem: 47205351
            NIKKAJI: J247.065I
///
ENTRY       C16042            Peptide   Compound
NAME        Met-enkephalin-Arg-Gly-Leu
SEQUENCE    Tyr Gly Gly Phe Met Arg Gly Leu
  ORGANISM  Human [HSA:5179] [UP:PENK_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C16042  Met-enkephalin-Arg-Gly-Leu
DBLINKS     PubChem: 47205352
            NIKKAJI: J374.467A
///
ENTRY       C16043            Peptide   Compound
NAME        Met-enkephalin-Arg-Phe
SEQUENCE    Tyr Gly Gly Phe Met Arg Phe
  ORGANISM  Human [HSA:5179] [UP:PENK_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C16043  Met-enkephalin-Arg-Phe
DBLINKS     PubChem: 47205353
            NIKKAJI: J374.466C
///
ENTRY       C15890            Peptide   Compound
NAME        Endomorphin-1
SEQUENCE    Tyr Pro Trp Phe-NH2
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C15890  Endomorphin-1
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                mu-opioid receptor
                 C15890  Endomorphin-1
DBLINKS     PubChem: 47205210
            NIKKAJI: J830.103D
///
ENTRY       C15891            Peptide   Compound
NAME        Endomorphin-2
SEQUENCE    Tyr Pro Phe Phe-NH2
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C15891  Endomorphin-2
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                mu-opioid receptor
                 C15891  Endomorphin-2
DBLINKS     PubChem: 47205211
            NIKKAJI: J454.979A
///
ENTRY       C01574            Peptide   Compound
NAME        Dynorphin;
            Dynorphin A
SEQUENCE    Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn
            Gln
  ORGANISM  Human [HSA:5173] [UP:PDYN_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C01574  Dynorphin A
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                kappa-opioid receptor
                 C01574  Dynorphin A
                mu-opioid receptor
                 C01574  Dynorphin
DBLINKS     CAS: 74913-18-1
            PubChem: 4731
///
ENTRY       C16135            Peptide   Compound
NAME        Dynorphin B;
            Rimorphin
SEQUENCE    Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr
  ORGANISM  Human [HSA:5173] [UP:PDYN_HUMAN]
PATHWAY     map04080  Neuroactive ligand-receptor interaction
BRITE       Bioactive peptides [BR:br08005]
             Neuropeptides
              Endogenous opioid peptide
               C16135  Dynorphin B
            Target-based classification of compounds [BR:br08010]
             G Protein-coupled receptors
              Rhodopsin family: peptide receptors
               Opioid
                kappa-opioid receptor
                 C16135  Dynorphin B
DBLINKS     CAS: 83335-41-5
            PubChem: 47205445
            NIKKAJI: J39.439D
///
ENTRY       C01516                      Compound
NAME        Morphine
FORMULA     C17H19NO3
EXACT_MASS  285.1365
MOL_WEIGHT  285.3377



REMARK      Same as: D08233
REACTION    R03591 R03592 R03697 R08262 R08263 R08265 R09402
PATHWAY     map00950  Isoquinoline alkaloid biosynthesis
            map00982  Drug metabolism - cytochrome P450
            map01063  Biosynthesis of alkaloids derived from shikimate pathway
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
            map04080  Neuroactive ligand-receptor interaction
ENZYME      1.1.1.218       1.14.11.32      1.14.14.1       2.4.1.17
BRITE       Compounds with biological roles [BR:br08001]
             Phytochemical compounds
              Alkaloids
               C01516  Morphine
            Phytochemical compounds [BR:br08003]
             Alkaloids
              Alkaloids derived from tyrosine
               Isoquinoline alkaloids
                C01516  Morphine
            Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
             N NERVOUS SYSTEM
              N02 ANALGESICS
               N02A OPIOIDS
                N02AA Natural opium alkaloids
                 N02AA01 Morphine
                  D08233  Morphine (BAN)
            USP drug classification [BR:br08302]
             Analgesics
              Opioid Analgesics, Long-acting
               Morphine
                D08233  Morphine (BAN)
            Target-based classification of drugs [BR:br08310]
             G Protein-coupled receptors
              Rhodopsin family
               Opioid
                mu-opioid receptor
                 Morphine
                  D08233  Morphine (BAN)
            Major components of natural products [BR:br08323]
             Crude drugs
              Opium, powdered
               C01516  Morphine
            Phytochemicals used as drugs [BR:br08306]
             Alkaloids
              Alkaloids derived from tyrosine
               Isoquinoline alkaloids
                D08233  Morphine (BAN)
DBLINKS     CAS: 57-27-2
            PubChem: 4681
            ChEBI: 17303
            KNApSAcK: C00001889
            PDB-CCD: MOI
            3DMET: B04801
            NIKKAJI: J2.323J
ATOM        21
            1   C1z C    21.5384  -23.5506
            2   C8y C    21.5384  -22.2288
            3   C1y C    22.7210  -24.2462
            4   C1y C    20.4253  -24.1767
            5   C1x C    22.7210  -22.9245
            6   C8y C    20.4253  -21.6027
            7   C8y C    22.7210  -21.6027
            8   C1y C    23.8341  -23.5506
            9   C2x C    22.7210  -25.4984
            10  O2x O    19.1036  -22.8548
            11  C1y C    20.4253  -25.4984
            12  C1x C    24.9471  -22.9245
            13  C8y C    20.4253  -20.2809
            14  C1x C    23.8341  -22.2983
            15  C8x C    22.7210  -20.2809
            16  N1y N    24.9471  -24.2462
            17  C2x C    21.5384  -26.1941
            18  O1a O    19.3123  -26.1941
            19  C8x C    21.6080  -19.6549
            20  O1a O    19.3123  -19.6549
            21  C1a C    26.3437  -24.2462
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 2
            17   11  18 1 #Down
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25   16  21 1
///
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