KEGG   COMPOUND: C01926Help
Entry
C01926                      Compound                               

Name
Indomethacin;
Indometacin
Formula
C19H16ClNO4
Exact mass
357.0768
Mol weight
357.7876
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB03 Indometacin
      D00141  Indomethacin (USP)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB01 Indometacin
      D00141  Indomethacin (USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA23 Indometacin
      D00141  Indomethacin (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC01 Indometacin
      D00141  Indomethacin (USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indomethacin (USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indomethacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1145  Indomethacins
     D00141  Indomethacin (USP); Indometacin (JP17/INN)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00141  Indomethacin (USP); Indometacin (JP17/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00141  Indomethacin (USP); Indometacin (JP17/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00141  Indomethacin (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Indometacin
    D00141  Indomethacin (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Indometacin
     D00141  Indomethacin (USP)
   cyclooxygenase-2 (COX-2)
    Indometacin
     D00141  Indomethacin (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Indometacin
    D00141  Indomethacin (USP)
 CYP substrates
  CYP2C19
   Indometacin
    D00141  Indomethacin (USP)
 Transporter inhibitors
  OAT2
   Indometacin
    D00141  Indomethacin (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00141  Indometacin
  D00141  Indometacin capsules
  D00141  Indometacin suppositories
Anesthetics and analgesics [br08369.html]
 Analgesics
  D00141
Rx-to-OTC switch list in Japan [br08314.html]
 D00141
BRITE hierarchy
Other DBs
CAS: 
53-86-1
PubChem: 
ChEBI: 
KNApSAcK: 
PDB-CCD: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    13.5100  -16.5200
            2   C8x C    13.5100  -17.9200
            3   C8x C    14.7224  -18.6200
            4   C8y C    15.9349  -17.9200
            5   C8y C    15.9349  -16.5200
            6   C8x C    14.7224  -15.8200
            7   N4y N    17.2664  -18.3526
            8   C8y C    18.0893  -17.2200
            9   C8y C    17.2664  -16.0874
            10  O2a O    12.2976  -15.8200
            11  C1a C    11.1021  -16.5104
            12  C1b C    17.6975  -14.7606
            13  C6a C    19.0769  -14.4674
            14  O6a O    20.0395  -15.5369
            15  O6a O    19.5063  -13.1473
            16  C1a C    19.4600  -17.2200
            17  C5a C    17.6975  -19.6794
            18  C8y C    18.9100  -20.3794
            19  C8x C    18.9099  -21.7700
            20  C8x C    20.1223  -22.4700
            21  C8y C    21.3348  -21.7701
            22  C8x C    21.3349  -20.3795
            23  C8x C    20.1224  -19.6794
            24  O5a O    16.6217  -20.5507
            25  X   Cl   22.5585  -22.4768
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    1  10 1
            12   10  11 1
            13    9  12 1
            14   12  13 1
            15   13  14 2
            16   13  15 1
            17    8  16 1
            18    7  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   17  24 2
            27   21  25 1

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