KEGG   COMPOUND: C01926Help
Entry
C01926                      Compound                               

Name
Indomethacin;
Indometacin
Formula
C19H16ClNO4
Exact mass
357.0768
Mol weight
357.7876
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB03 Indometacin
      D00141  Indometacin (JP17/INN); Indomethacin (USP)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB01 Indometacin
      D00141  Indometacin (JP17/INN); Indomethacin (USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA23 Indometacin
      D00141  Indometacin (JP17/INN); Indomethacin (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC01 Indometacin
      D00141  Indometacin (JP17/INN); Indomethacin (USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1145  Indomethacins
     D00141  Indometacin (JP17/INN); Indomethacin (USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00141  Indometacin (JP17/INN); Indomethacin (USP)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00141  Indometacin (JP17/INN); Indomethacin (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00141  Indometacin (JP17/INN); Indomethacin (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Indometacin
    D00141  Indometacin (JP17/INN); Indomethacin (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Indometacin
     D00141  Indometacin (JP17/INN); Indomethacin (USP)
   cyclooxygenase-2 (COX-2)
    Indometacin
     D00141  Indometacin (JP17/INN); Indomethacin (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Indometacin
    D00141  Indometacin (JP17/INN); Indomethacin (USP)
 CYP substrates
  CYP2C19
   Indometacin
    D00141  Indometacin (JP17/INN); Indomethacin (USP)
 Transporter inhibitors
  OAT2
   Indometacin
    D00141  Indometacin (JP17/INN); Indomethacin (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00141  Indometacin
  D00141  Indometacin capsules
  D00141  Indometacin suppositories
Anesthetics and analgesics [br08369.html]
 Analgesics
  D00141
Rx-to-OTC switch list in Japan [br08314.html]
 D00141
BRITE hierarchy
Other DBs
CAS: 
53-86-1
PubChem: 
ChEBI: 
KNApSAcK: 
PDB-CCD: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    13.5100  -16.5200
            2   C8x C    13.5100  -17.9200
            3   C8x C    14.7224  -18.6200
            4   C8y C    15.9349  -17.9200
            5   C8y C    15.9349  -16.5200
            6   C8x C    14.7224  -15.8200
            7   N4y N    17.2664  -18.3526
            8   C8y C    18.0893  -17.2200
            9   C8y C    17.2664  -16.0874
            10  O2a O    12.2976  -15.8200
            11  C1a C    11.1021  -16.5104
            12  C1b C    17.6975  -14.7606
            13  C6a C    19.0769  -14.4674
            14  O6a O    20.0395  -15.5369
            15  O6a O    19.5063  -13.1473
            16  C1a C    19.4600  -17.2200
            17  C5a C    17.6975  -19.6794
            18  C8y C    18.9100  -20.3794
            19  C8x C    18.9099  -21.7700
            20  C8x C    20.1223  -22.4700
            21  C8y C    21.3348  -21.7701
            22  C8x C    21.3349  -20.3795
            23  C8x C    20.1224  -19.6794
            24  O5a O    16.6217  -20.5507
            25  X   Cl   22.5585  -22.4768
BOND        27
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    1  10 1
            12   10  11 1
            13    9  12 1
            14   12  13 1
            15   13  14 2
            16   13  15 1
            17    8  16 1
            18    7  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   17  24 2
            27   21  25 1

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