KEGG   COMPOUND: C06868Help
Entry
C06868                      Compound                               

Name
Carbamazepine
Formula
C15H12N2O
Exact mass
236.095
Mol weight
236.2686
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Reaction
Pathway
Drug metabolism - cytochrome P450
Enzyme
1.14.13.-       1.14.14.1
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF01 Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 Bipolar Agents
  Mood Stabilizers
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00252  Carbamazepine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN2A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN3A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN4A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN5A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN8A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN9A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 CYP inducers
  CYP2C9
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP2C19
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A4
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A5
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A7
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 CYP substrates
  CYP2B6
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP2C8
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A4
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 Transporter inducers
  ABCB1
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00252  Carbamazepine
Neurological agents [br08367.html]
 Antiepileptic agents
  D00252
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00252
BRITE hierarchy
Other DBs
CAS: 
298-46-4
PubChem: 
ChEBI: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    25.8139  -16.0918
            2   N1y N    27.0679  -15.4768
            3   C8y C    28.3385  -16.0677
            4   C8y C    28.6646  -17.4200
            5   C8y C    25.5184  -17.4703
            6   C2x C    27.8110  -18.5337
            7   C2x C    26.4090  -18.5521
            8   C8x C    24.7745  -15.1529
            9   C8x C    23.4416  -15.5834
            10  C8x C    23.1462  -16.9619
            11  C8x C    24.1856  -17.9009
            12  C8x C    30.0177  -17.7825
            13  C8x C    31.0081  -16.7920
            14  C8x C    30.6456  -15.4389
            15  C8x C    29.2926  -15.0764
            16  C5a C    27.1235  -14.0772
            17  O5a O    25.8857  -13.3793
            18  N1a N    28.3127  -13.3740
BOND        20
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1

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