KEGG   COMPOUND: C06924Help
Entry
C06924                      Compound                               

Name
Clozapine
Formula
C18H19ClN4
Exact mass
326.1298
Mol weight
326.8233
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH02 Clozapine
      D00283  Clozapine (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  Treatment-Resistant
   Clozapine
    D00283  Clozapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00283  Clozapine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
   Dopamine
    dopamine D2-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    dopamine D4-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
   Serotonin
    5-HT1A-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    5-HT2A-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    5-HT2C-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    5-HT7-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Clozapine
    D00283  Clozapine (JAN/USP/INN)
  CYP3A4
   Clozapine
    D00283  Clozapine (JAN/USP/INN)
Psychiatric agents [br08363.html]
 Antipsychotics
  D00283
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00283
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00283
BRITE hierarchy
Other DBs
CAS: 
5786-21-0
PubChem: 
ChEBI: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C2y C    23.0142  -13.7220
            2   C8y C    22.1726  -12.6130
            3   C8y C    22.5076  -11.2569
            4   N1x N    23.7680  -10.6791
            5   N2x N    24.4193  -13.7472
            6   C8y C    25.0209  -11.3010
            7   C8y C    25.3073  -12.6690
            8   C8x C    21.5010  -10.2890
            9   C8x C    20.1597  -10.6769
            10  C8x C    19.8247  -12.0330
            11  C8x C    20.8313  -13.0006
            12  C8x C    26.6378  -13.1059
            13  C8y C    27.6814  -12.1720
            14  C8x C    27.3952  -10.8040
            15  C8x C    26.0645  -10.3671
            16  N1y N    22.3801  -14.9710
            17  C1x C    20.9792  -14.9710
            18  C1x C    20.2788  -16.1842
            19  N1y N    20.9792  -17.3976
            20  C1x C    22.3801  -17.3976
            21  C1x C    23.0805  -16.1842
            22  X   Cl   29.0355  -12.6169
            23  C1a C    20.2726  -18.6209
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   16  21 1
            25   13  22 1
            26   19  23 1

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