KEGG   COMPOUND: C07072Help
Entry
C07072                      Compound                               

Name
Losartan
Formula
C22H23ClN6O
Exact mass
422.1622
Mol weight
422.9106
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA01 Losartan
      D08146  Losartan (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Losartan
    D08146  Losartan (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Losartan
      D08146  Losartan (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Losartan
    D08146  Losartan (INN)
  CYP3A4
   Losartan
    D08146  Losartan (INN)
 Transporter inhibitors
  ABCB11
   Losartan
    D08146  Losartan (INN)
  URAT1
   Losartan
    D08146  Losartan (INN)
BRITE hierarchy
Other DBs
CAS: 
114798-26-4
PubChem: 
ChEBI: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   N4y N    28.1559  -17.4542
            2   C8y C    28.5926  -18.7817
            3   C8y C    29.2912  -16.6217
            4   C1b C    26.9333  -16.7672
            5   N5x N    29.9898  -18.7817
            6   C1b C    27.7659  -19.9170
            7   C8y C    30.4265  -17.4542
            8   C1b C    29.2912  -15.2244
            9   C8y C    25.7339  -17.4892
            10  C1b C    28.3423  -21.1978
            11  X   Cl   31.7599  -17.0234
            12  O1a O    30.5023  -14.5256
            13  C8x C    25.7572  -18.8923
            14  C8x C    24.5054  -16.8079
            15  C1b C    27.5155  -22.3215
            16  C8x C    24.5520  -19.6085
            17  C8x C    23.2828  -17.5765
            18  C1a C    28.0919  -23.6024
            19  C8y C    23.3411  -18.9272
            20  C8y C    22.1358  -19.6433
            21  C8y C    20.9073  -18.9679
            22  C8x C    22.0892  -21.0406
            23  C8y C    20.9307  -17.5648
            24  C8x C    19.6439  -19.6841
            25  C8x C    20.9597  -21.7626
            26  N4x N    19.8012  -16.7613
            27  N5x N    22.0603  -16.7206
            28  C8x C    19.6963  -21.1339
            29  N5x N    20.2088  -15.4222
            30  N5x N    21.6061  -15.3989
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

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