KEGG   COMPOUND: C07148Help
Entry
C07148                      Compound                               

Name
Tolbutamide
Formula
C12H18N2O3S
Exact mass
270.1038
Mol weight
270.3479
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB03 Tolbutamide
      D00380  Tolbutamide (JP17/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Tolbutamide
    D00380  Tolbutamide (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00380  Tolbutamide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    ATP-sensitive potassium channel (SUR1/Kir6.2)
     Tolbutamide
      D00380  Tolbutamide (JP17/USP/INN)
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Tolbutamide
      D00380  Tolbutamide (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C8
   Tolbutamide
    D00380  Tolbutamide (JP17/USP/INN)
  CYP2C9
   Tolbutamide
    D00380  Tolbutamide (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00380  Tolbutamide
  D00380  Tolbutamide tablets
Antidiabetics [br08361.html]
 D00380
BRITE hierarchy
Other DBs
CAS: 
64-77-7
PubChem: 
ChEBI: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    33.3200  -19.6700
            2   S4a S    34.4400  -18.9700
            3   C8x C    32.0600  -19.0400
            4   C8x C    33.3200  -21.0700
            5   N1b N    35.9800  -19.7400
            6   O3c O    35.2800  -17.7800
            7   O3c O    33.4600  -17.7100
            8   C8x C    30.8700  -19.6700
            9   C8x C    32.1300  -21.7700
            10  C5a C    37.1000  -19.0400
            11  C8y C    30.8700  -21.0700
            12  N1b N    38.3600  -19.6700
            13  O5a O    37.1000  -17.6400
            14  C1a C    29.6800  -21.7700
            15  C1b C    39.4800  -18.9700
            16  C1b C    40.6700  -19.6000
            17  C1b C    41.7900  -18.9000
            18  C1a C    42.9100  -19.5300
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     2   7 2
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    8  11 1
            11   10  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18    9  11 2

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