KEGG   COMPOUND: C07592Help
Entry
C07592                      Compound                               

Name
Colchicine
Formula
C22H25NO6
Exact mass
399.1682
Mol weight
399.437
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Reaction
Pathway
Isoquinoline alkaloid biosynthesis
Biosynthesis of alkaloids derived from shikimate pathway
Biosynthesis of secondary metabolites
Brite
Phytochemical compounds [BR:br08003]
 Alkaloids
  Alkaloids derived from tyrosine
   Isoquinoline alkaloids
    C07592  Colchicine
Natural toxins [BR:br08009]
 Phytotoxins
  Alkaloids
   Isoquinoline alkaloids
    C07592  Colchicine
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AC Preparations with no effect on uric acid metabolism
     M04AC01 Colchicine
      D00570  Colchicine (JP17/USP)
USP drug classification [BR:br08302]
 Antigout Agents
  Colchicine
   D00570  Colchicine (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3941  Colchicines
     D00570  Colchicine (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Others
  Cytoskeleton proteins
   beta-tubulin
    Colchicine
     D00570  Colchicine (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Colchicine
    D00570  Colchicine (JP17/USP)
  CYP3A
   Colchicine
    D00570  Colchicine (JP17/USP)
 Transporter substrates
  ABCB1
   Colchicine
    D00570  Colchicine (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00570  Colchicine
Major components of natural products [BR:br08323]
 Crude drugs
  Colchicum seed; Colchicum bulb
   C07592  Colchicine
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tyrosine
   Isoquinoline alkaloids
    D00570  Colchicine (JP15/USP)
Antirheumatic and antigout drugs [br08366.html]
 Antigout drugs
  D00570
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00570
BRITE hierarchy
Other DBs
CAS: 
64-86-8
PubChem: 
ChEBI: 
KNApSAcK: 
PDB-CCD: 
3DMET: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1x C    24.2478  -17.8139
            2   C8y C    23.4047  -16.6897
            3   C8y C    23.7560  -15.3547
            4   C1x C    25.6531  -17.8139
            5   C2y C    26.2855  -15.4249
            6   C1y C    26.5665  -16.7599
            7   C8y C    22.7021  -14.3710
            8   C8y C    21.3671  -14.7926
            9   C8y C    21.0158  -16.1276
            10  C8x C    22.0698  -17.1113
            11  O2a O    22.9832  -12.9657
            12  O2a O    20.3835  -13.8089
            13  O2a O    19.6808  -16.5491
            14  C2y C    25.0496  -14.7559
            15  C2x C    24.7816  -13.3324
            16  C2x C    25.7262  -12.3959
            17  C2y C    27.1396  -12.3717
            18  C5x C    27.9507  -13.5299
            19  C2x C    27.5622  -14.8377
            20  C1a C    18.6442  -15.6002
            21  C1a C    20.7471  -12.4515
            22  C1a C    24.3143  -12.5154
            23  O5x O    29.3587  -13.5119
            24  O2a O    27.7928  -11.1651
            25  C1a C    29.1664  -11.1969
            26  N1b N    27.9270  -17.1121
            27  C5a C    29.1062  -16.3876
            28  C1a C    30.3329  -17.0467
            29  O5a O    29.1333  -14.9844
BOND        31
            1     1   4 1
            2     2   3 1
            3     4   6 1
            4     1   2 1
            5     5   6 1
            6     3   7 2
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10    2  10 2
            11    7  11 1
            12    8  12 1
            13    9  13 1
            14   16  17 2
            15   17  18 1
            16   15  16 1
            17    5  19 2
            18   14  15 2
            19   18  19 1
            20    3  14 1
            21   14   5 1
            22   13  20 1
            23   12  21 1
            24   11  22 1
            25   18  23 2
            26   17  24 1
            27   24  25 1
            28    6  26 1 #Up
            29   26  27 1
            30   27  28 1
            31   27  29 2

» Japanese version

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