KEGG   COMPOUND: C07783Help
Entry
C07783                      Compound                               

Name
Dexchlorpheniramine maleate;
d-Chlorpheniramine maleate
Formula
C16H19ClN2. C4H4O4
Exact mass
390.1346
Mol weight
390.8606
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB02 Dexchlorpheniramine
      D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Allergic agents
  52 Antihistamine based drugs
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  -- Allergic agents (oral use)
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Dexchlorpheniramine
      D00668  Dexchlorpheniramine maleate (USP)
     Chlorphenamine
      D00668  Dexchlorpheniramine maleate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  CYP3A4
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  CYP3A5
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
  CYP3A7
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
 Inhbitors
  CYP2D6
   Dexchlorpheniramine
    D00668  d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00668  d-Chlorpheniramine maleate
Animal drugs in Japan [BR:br08331]
 96  Agents affecting metabolism
  968  Antiallergic agents (including nonspecific antigen preparations)
   9682  Chlorpheniramine, derivatives and preparations
    C07783  Dexchlorpheniramine maleate
BRITE hierarchy
Other DBs
CAS: 
2438-32-6
PubChem: 
KCF data Show

ATOM        27
            1   C8x C    20.5308  -17.4126
            2   C8y C    20.5308  -18.8307
            3   C8x C    21.7590  -19.5398
            4   C8x C    22.9872  -18.8307
            5   C8y C    22.9872  -17.4126
            6   C8x C    21.7590  -16.7035
            7   C8x C    25.4435  -18.8307
            8   C8y C    25.4435  -17.4126
            9   C1c C    24.2153  -16.7035
            10  C8x C    26.6717  -19.5398
            11  C8x C    27.8998  -18.8307
            12  C8x C    27.8998  -17.4126
            13  N5x N    26.6717  -16.7035
            14  X   Cl   19.3027  -19.5398
            15  C1b C    24.2153  -15.2853
            16  C1b C    25.4456  -14.5750
            17  N1c N    25.4456  -13.1583
            18  C1a C    26.6572  -12.4586
            19  C1a C    24.2008  -12.4395
            20  C6a C    33.4785  -15.9462
            21  C2b C    32.8034  -14.7815
            22  O6a O    32.8789  -17.1864
            23  O6a O    34.8291  -15.9399
            24  C2b C    31.1865  -14.7877
            25  C6a C    30.5175  -15.9585
            26  O6a O    29.1669  -15.9585
            27  O6a O    31.1990  -17.1925
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    2  14 1
            16    9  15 1 #Down
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   20  21 1
            22   20  22 1
            23   20  23 2
            24   21  24 2
            25   24  25 1
            26   25  26 1
            27   25  27 2

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