KEGG   COMPOUND: C15643Help
Entry
C15643                      Compound                               

Name
Dexamethasone
Formula
C22H29FO5
Exact mass
392.1999
Mol weight
392.4611
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00292  Dexamethasone (JP17/USP/INN)
  Dexamethasone
   D00292  Dexamethasone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00292  Dexamethasone (JP17/USP/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00292  Dexamethasone (JP17/USP/INN)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00292  Dexamethasone (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00292  Dexamethasone (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    glucocorticoid receptor
     Dexamethasone
      D00292  Dexamethasone (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP2D6
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
 CYP substrates
  CYP3A4
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
  CYP3A5
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
  CYP3A7
   Dexamethasone
    D00292  Dexamethasone (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00292  Dexamethasone
Gastrointestinal agents [br08371.html]
 Agent for intraoral diseases
  D00292
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00292
Topical steroids [br08317.html]
 Classification in Japan
  D00292
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00292
Rx-to-OTC switch list in Japan [br08314.html]
 D00292
Animal drugs in Japan [BR:br08331]
 95  Agents for external use
  953  Analgesics, anti-itchings, astringents and antiinflammatory agents
   9539  Other analgesics, anti-itchings, astringents and inflammatory agents
    C15643  Dexamethasone
 96  Agents affecting metabolism
  961  Hormone preparations (except agents for breeding and external use)
   9612  Adrenal hormone preparations
    C15643  Dexamethasone
BRITE hierarchy
Other DBs
CAS: 
50-02-2
PubChem: 
ChEBI: 
PDB-CCD: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C2x C    15.4700  -16.9400
            2   C5x C    15.4700  -18.3400
            3   C2x C    16.6824  -19.0400
            4   C2y C    17.8949  -18.3400
            5   C1z C    17.8949  -16.9400
            6   C2x C    16.6824  -16.2400
            7   C1x C    19.1073  -19.0400
            8   C1x C    20.3197  -18.3400
            9   C1y C    20.3197  -16.9400
            10  C1z C    19.1073  -16.2400
            11  C1y C    21.5322  -16.2400
            12  C1z C    21.5322  -14.8400
            13  C1x C    20.3197  -14.1400
            14  C1y C    19.1073  -14.8400
            15  C1x C    23.9570  -16.2400
            16  C1y C    23.9570  -14.8400
            17  C1z C    22.7446  -14.1400
            18  C5a C    22.7446  -12.2500
            19  C1b C    23.9611  -11.5477
            20  O5a O    21.5362  -11.5523
            21  O1a O    25.1586  -12.2392
            22  O1a O    23.7511  -13.1577
            23  C1a C    25.1566  -14.1473
            24  X   F    19.1073  -17.6400
            25  O5x O    14.2576  -19.0400
            26  C1a C    21.5322  -13.4400
            27  C1a C    17.8949  -15.5400
            28  O1a O    18.1174  -13.8501
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   15  16 1
            18   16  17 1
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 2
            23   19  21 1
            24   17  22 1 #Down
            25   16  23 1 #Down
            26   10  24 1 #Down
            27    2  25 2
            28   11  15 1
            29   12  26 1 #Up
            30    5  27 1 #Up
            31   14  28 1 #Up

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