KEGG   PATHWAY: dme03420
Entry
dme03420                    Pathway                                
Name
Nucleotide excision repair - Drosophila melanogaster (fruit fly)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
dme03420  Nucleotide excision repair
dme03420

Other DBs
GO: 0006289
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG16982  Roc1a; regulator of cullins 1a, isoform D [KO:K03868] [EC:2.3.2.32]
Dmel_CG16988  Roc1b; regulator of cullins 1b [KO:K03868] [EC:2.3.2.32]
Dmel_CG8711  Cul4; cullin 4, isoform B [KO:K10609]
Dmel_CG7769  pic; piccolo [KO:K10610]
Dmel_CG8153  Xpc; xeroderma pigmentosum, complementation group C, isoform A [KO:K10838]
Dmel_CG1836  Rad23; Rad23, isoform C [KO:K10839]
Dmel_CG10694  CG10694; uncharacterized protein [KO:K10839]
Dmel_CG1554  Polr2A; RNA polymerase II subunit A [KO:K03006] [EC:2.7.7.6]
Dmel_CG3180  Polr2B; RNA polymerase II subunit B, isoform B [KO:K03010] [EC:2.7.7.6]
Dmel_CG7885  Polr2C; RNA polymerase II subunit C [KO:K03011]
Dmel_CG43662  Polr2D; RNA polymerase II subunit D [KO:K03012]
Dmel_CG11979  Polr2E; RNA polymerase II, I and III subunit E, isoform B [KO:K03013]
Dmel_CG1163  Polr2F; RNA polymerase II, I and III subunit F [KO:K03014]
Dmel_CG31155  Polr2G; RNA polymerase II subunit G [KO:K03015]
Dmel_CG11246  Polr2H; RNA polymerase II, I and III subunit H [KO:K03016]
Dmel_CG3284  Polr2I; RNA polymerase II subunit I, isoform B [KO:K03017]
Dmel_CG13628  Polr2L; RNA polymerase II, I and III subunit L [KO:K03007]
Dmel_CG34186  Polr2K; RNA polymerase II, I and III subunit K [KO:K03009]
Dmel_CG6840  Polr2J; RNA polymerase II subunit J [KO:K03008]
Dmel_CG3773  Polr2M; RNA polymerase II subunit M [KO:K21987]
Dmel_CG3319  Cdk7; Cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
Dmel_CG7614  Mat1; menage a trois 1 [KO:K10842]
Dmel_CG7405  CycH; cyclin H [KO:K06634]
Dmel_CG8019  hay; haywire, isoform B [KO:K10843] [EC:5.6.2.4]
Dmel_CG9433  Xpd; xeroderma pigmentosum D [KO:K10844] [EC:5.6.2.3]
Dmel_CG42373  Tfb5; transcription factor B5 [KO:K10845]
Dmel_CG8151  Tfb1; transcription factor B1, isoform D [KO:K03141]
Dmel_CG11115  Ssl1; suppressor of stem-loop mutation, isoform B [KO:K03142]
Dmel_CG5041  Tfb4; transcription factor B4 [KO:K03143]
Dmel_CG7764  mrn; marionette [KO:K03144]
Dmel_CG10890  mus201; mutagen-sensitive 201, isoform C [KO:K10846]
Dmel_CG6358  Xpac; xeroderma pigmentosum group A-like [KO:K10847]
Dmel_CG9633  RPA1; replication protein A1 [KO:K07466]
Dmel_CG9273  RPA2; replication protein A2, isoform B [KO:K10739]
Dmel_CG15220  RPA3; replication protein A3, isoform B [KO:K10740]
Dmel_CG3697  mei-9; meiotic 9, isoform B [KO:K10848] [EC:3.1.-.-]
Dmel_CG10215  Ercc1; Ercc1 [KO:K10849]
Dmel_CG5949  PolD1; DNA polymerase delta subunit 1 [KO:K02327] [EC:2.7.7.7]
Dmel_CG12018  PolD2; DNA polymerase delta subunit 2 [KO:K02328]
Dmel_CG3975  PolD3; DNA polymerase delta subunit 3, isoform B [KO:K03504]
Dmel_CG6768  PolE1; DNA polymerase epsilon subunit 1 [KO:K02324] [EC:2.7.7.7]
Dmel_CG10489  PolE2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
Dmel_CG13399  Chrac-14; chromatin accessibility complex 14kD protein [KO:K02326] [EC:2.7.7.7]
Dmel_CG11301  PolE4; DNA polymerase epsilon subunit 4, isoform B [KO:K03506] [EC:2.7.7.7]
Dmel_CG9193  PCNA; proliferating cell nuclear antigen, isoform A [KO:K04802]
Dmel_CG10262  PCNA2; proliferating cell nuclear antigen 2 [KO:K04802]
Dmel_CG1119  Gnf1; germ line transcription factor 1, isoform A [KO:K10754]
Dmel_CG8142  CG8142; uncharacterized protein [KO:K10755]
Dmel_CG14999  RfC4; replication factor C subunit 4 [KO:K10755]
Dmel_CG5313  RfC3; replication factor C subunit 3 [KO:K10756]
Dmel_CG6258  RfC38; replication factor C 38kD subunit, isoform B [KO:K10756]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
dme03020  RNA polymerase
dme04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (52)   

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