KEGG   Drosophila melanogaster (fruit fly): Dmel_CG10079Help
Entry
Dmel_CG10079      CDS       T00030                                 

Gene name
Egfr
Definition
(RefSeq) Epidermal growth factor receptor (EC:2.7.10.-)
  KO
K04361  
epidermal growth factor receptor [EC:2.7.10.1]
Organism
dme  Drosophila melanogaster (fruit fly)
Pathway
MAPK signaling pathway - fly
FoxO signaling pathway
Endocytosis
Apoptosis - fly
Dorso-ventral axis formation
Brite
KEGG Orthology (KO) [BR:dme00001]
 Environmental Information Processing
  Signal transduction
   04013 MAPK signaling pathway - fly
    Dmel_CG10079 (Egfr)
   04068 FoxO signaling pathway
    Dmel_CG10079 (Egfr)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    Dmel_CG10079 (Egfr)
  Cell growth and death
   04214 Apoptosis - fly
    Dmel_CG10079 (Egfr)
 Organismal Systems
  Development
   04320 Dorso-ventral axis formation
    Dmel_CG10079 (Egfr)
Enzymes [BR:dme01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     Dmel_CG10079 (Egfr)
Protein kinases [BR:dme01001]
 Tyrosine protein kinases
  EGFR family [OT]
   Dmel_CG10079 (Egfr)
Exosome [BR:dme04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   Dmel_CG10079 (Egfr)
  Exosomal proteins of pancreatic cancer cells
   Dmel_CG10079 (Egfr)
  Exosomal proteins of bladder cancer cells
   Dmel_CG10079 (Egfr)
Enzyme-linked receptors [BR:dme01020]
 Receptor tyrosine kinases
  RTK class I (EGF receptor family)
   Dmel_CG10079 (Egfr)
Cytokine receptors [BR:dme04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   Dmel_CG10079 (Egfr)
Cell adhesion molecules and their ligands [BR:dme04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule [KO:K06550]
     Dmel_CG10079 (Egfr)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
FlyBase: 
UniProt: 
Structure
PDB: 

Jmol
Position
2R:57E9-57F1
AA seq 1426 aa AA seqDB search
MLLRRRNGPCPFPLLLLLLAHCICIWPASAARDRYARQNNRQRHQDIDRDRDRDRFLYRS
SSAQNRQRGGANFALGLGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYR
NLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIR
GRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVS
NGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPR
ECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGA
TCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNC
TVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQF
RNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVS
NIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNG
TCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYN
DRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYV
HPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTD
EEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHV
NYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKK
ETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPE
GENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMP
LGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKIT
DFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRP
HENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARD
PGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPGPSHRTD
CTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPN
NNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPV
MGVPGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNTETRV
NT seq 4281 nt NT seq  +upstreamnt  +downstreamnt
atgctgctgcgacggcgcaacggcccctgccccttccccctgctgctcctgctcctggcc
cactgcatttgcatttggcccgcgtcggcggcccgcgatcgctacgcccgccagaacaat
cgccagcgccatcaggatatagatcgcgatcgggatcgagatcgattcctataccgcagc
agttcggcccaaaatcgacagaggggcggggccaacttcgccctgggactgggagccaac
ggagtcaccattcccaccagtctggaggataagaacaagaacgagttcgtcaaggggaaa
atctgcatcggcactaaatctcggctctccgtgccctccaacaaggaacatcattaccgg
aacctcagagatcggtacacgaactgtacgtatgtggatggcaacctggagctgacctgg
ctgcccaacgagaatttggacctcagcttcctggacaacatacgggaggtcaccggctat
attctgatcagtcatgtggacgttaagaaagtggtatttcccaaactacaaatcattcgc
ggacgcacgctgttcagcttatccgtggaggaggagaagtatgccttgttcgtcacttat
tccaaaatgtacacgctggagattcccgatctacgcgatgtcttaaatggccaagtgggc
ttccacaacaactacaatctctgccacatgcgaacgatccagtggtcggagattgtatcc
aacggcacggatgcatactacaactacgactttactgctccggagcgcgagtgtcccaag
tgccacgagagctgcacgcacggatgttggggcgagggtcccaagaattgccagaagttc
agcaagctcacctgctcgccacagtgtgccggaggtcgttgctatggaccaaagccgcgg
gagtgttgtcacctcttctgcgccggaggatgcactggtcccacgcaaaaggattgcatc
gcctgcaagaacttcttcgacgagggcgtatgcaaggaggaatgcccgcccatgcgcaag
tacaatcccaccacctatgttcttgaaacgaatcctgagggaaagtatgcctatggtgcc
acctgcgtcaaggagtgtcccggtcatctgttgcgtgataatggcgcctgcgtgcgcagc
tgtccccaggacaagatggacaaggggggcgagtgtgtgccctgcaatggaccgtgcccc
aaaacctgcccgggcgttactgtcctgcatgccggcaacattgactcgttccggaattgt
acggtgatcgatggcaacattcgcattttggatcagaccttctcgggcttccaggatgtc
tatgccaactacacgatgggaccacgatacataccgctggatcccgagcgactggaggtg
ttctccacggtgaaggagatcaccgggtatctgaatatcgagggaacccacccgcagttc
cggaatctgtcgtacttccgcaatctggaaacaattcatggccgccagctgatggagagc
atgtttgccgctttggcgatcgttaagtcatccctgtacagcctggagatgcgcaatctg
aagcagattagttccggcagtgtggtcatccagcataatagagacctctgctacgtaagc
aatatccgttggccggccattcagaaggagcccgaacagaaggtgtgggtcaacgagaat
ctcagggcggatctatgcgagaaaaatggaaccatttgctcggatcagtgcaacgaggac
ggctgctggggagctggcacggatcagtgccttacctgcaagaacttcaatttcaatggc
acctgcatcgccgactgtggttatatatccaatgcctacaagtttgacaatagaacgtgc
aagatatgccatccagagtgccggacttgcaatggagctggagcagatcactgccaggag
tgcgtccatgtgagggacggtcagcactgtgtgtccgagtgcccgaagaacaagtacaac
gatcgtggtgtctgccgagagtgccacgccacctgcgatggatgcactgggcccaaggac
accatcggcattggagcgtgtacaacgtgcaatttggccattatcaacaatgacgccaca
gtaaaacgctgcctgctgaaggacgacaagtgccccgatgggtacttctgggagtatgtg
catccacaagagcagggatcgctaaagccattggccggcagagcagtttgccgaaagtgc
catcccctttgcgagctgtgcaccaactacggataccatgaacaggtgtgctccaagtgc
acccactacaagcgacgagagcagtgcgagaccgagtgtccggccgatcactacacggat
gaggagcagcgcgagtgcttccagtgccacccagaatgcaacggttgcactggtccgggt
gccgacgattgcaagtcttgtcgcaacttcaagttgttcgacgcgaatgagacgggtccc
tatgtgaactccacgatgttcaattgcacctcgaagtgtcccttggagatgcgacatgtg
aactatcagtacacggccattggaccctactgtgcagctagtccgccgaggagcagcaag
ataactgccaatctggatgtgaacatgatcttcattatcactggtgctgttctggtgccg
acgatctgcatcctctgcgtggtcacatacatttgtcggcaaaagcaaaaggccaagaaa
gaaacagtgaagatgaccatggctctgtccggctgtgaggattccgagccgctgcgtccc
tcgaacattggagccaatctatgcaagttgcgcattgtcaaggacgccgagttgcgcaag
ggcggagtcctcggaatgggagcctttggacgagtgtacaagggcgtttgggtgccggag
ggtgagaacgtcaagattccagtggccattaaggagctgctcaagtccacaggcgccgag
tcaagcgaagagttcctccgcgaagcctacatcatggcctctgtggagcacgttaatctg
ctgaagctcctggccgtctgcatgtcctcacaaatgatgctaatcacgcaactgatgccg
cttggctgcctgttggactatgtgcgaaataaccgggacaagatcggctctaaggctctg
ctcaactggagcacgcaaatcgccaagggcatgtcgtatctggaggagaagcgactggtc
cacagagacttggctgcccgcaatgtcctggtgcagactccctcgctggtgaagatcacc
gactttgggctggccaagttgctgagcagcgattccaatgagtacaaggctgctggcggc
aagatgcccatcaagtggttggcactggagtgcattcgcaatcgtgtattcaccagcaag
tccgatgtctgggcctttggtgtgacaatttgggaactgctgacctttggccagcgtcca
cacgagaacatccccgctaaggatattcccgatcttattgaagtcggtctgaagctggag
cagccggagatttgttcgctggacatttactgcacacttctctcgtgctggcacttggat
gccgccatgcgtccaaccttcaagcagctgactacggtctttgctgagttcgccagagat
ccgggtcgctatctggccattcccggggataagttcacccggctgccggcctacacgagt
caggatgagaaggatctcatccgaaaattggctcccaccaccgatgggtccgaagccatt
gcggaacccgatgactacctgcaacccaaggcagcacctggtcctagtcacagaaccgac
tgcacggatgagatacccaagctgaaccgctactgcaaggatcctagcaacaagaattcg
agtaccggagacgatgagacggattcgagtgcccgggaagtgggcgtgggtaatctgcgc
ctcgatctaccagtcgatgaggatgattacctgatgcccacatgccaaccggggcccaac
aacaacaacaacataaataatcccaatcaaaacaatatggcagctgtgggcgtggctgcc
ggctacatggatctcatcggagtgcccgttagtgtggacaatccggagtatctgctaaac
gcgcagacactgggtgttggggagtcgccgatacccacccagaccatcgggataccggtg
atgggagtcccgggcaccatggaggtcaaggtgccaatgccaggcagtgagccaacgagc
tccgatcacgagtactacaatgatacccaacgggagttgcagccactgcatcgaaaccgc
aacacggagacgagggtgtag

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