KEGG   DRUG: D00126Help
Entry
D00126                      Drug                                   
Name
Ibuprofen (JP16/USP/INN);
Advil (TN);
Motrin (TN)
Product
  Generic
IBUPROFEN (Actavis Mid Atlantic LLC), IBUPROFEN (Aidarex Pharmaceuticals LLC), IBUPROFEN (Altura Pharmaceuticals), IBUPROFEN (American Health Packaging), IBUPROFEN (Amneal Pharmaceuticals), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Apotheca), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Ascend Laboratories), IBUPROFEN (AvKARE), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Blenheim Pharmacal), IBUPROFEN (Bryant Ranch Prepack), IBU (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBU (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Dispensing Solutions), IBUPROFEN (Dispensing Solutions), IBU (Dr. Reddy's Laboratories Limited), IBUPROFEN (Golden State Medical Supply), IBUPROFEN (H.J. Harkins Company), IBUPROFEN (H.J. Harkins Company), IBUPROFEN (HHS/Program Support Center/Supply Service Center), IBU (KAISER FOUNDATION HOSPITALS), IBUPROFEN (KAISER FOUNDATION HOSPITALS), IBUPROFEN (Keltman Pharmaceuticals), IBUPROFEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), IBUPROFEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Legacy Pharmaceutical Packaging), IBUPROFEN (Life Line Home Care Services), IBUPROFEN (MARKSANS PHARMA LIMITED), IBUPROFEN (Major Pharmaceuticals), IBUPROFEN (Major Pharmaceuticals), IBUPROFEN (McKesson Contract Packaging), IBU (McKesson Packaging Services a business unit of McKesson Corporation), IBUPROFEN (Med Health Pharma), IBUPROFEN (MedVantx), IBUPROFEN (Medsource Pharmaceuticals), IBUPROFEN (NCS HealthCare of KY), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (Perrigo New York), PERRIGO IBUPROFEN (Perrigo Pharmaceuticals Company), IBUPROFEN (Perrigo Pharmaceuticals Company), IBUPROFEN (Physicians Total Care), IBUPROFEN (Polygen Pharmaceuticals LLC), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Qualitest Pharmaceuticals), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (Rebel Distributors Corp), IBUPROFEN (Rebel Distributors Corp), IBUPROFEN (Rebel Distributors Corp), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (Rising Pharmaceuticals), IBUPROFEN (STAT RX USA LLC), IBUPROFEN (STAT Rx USA LLC), IBUPROFEN (STAT Rx USA LLC), IBUPROFEN (Shasun Pharmaceuticals Limited), IBUPROFEN (State of Florida DOH Central Pharmacy), IBUPROFEN (State of Florida DOH Central Pharmacy), IBUPROFEN (Unit Dose Services), IBU (Unit Dose Services), IBU (Unit Dose Services), IBUPROFEN (VistaPharm)
  Other
Formula
C13H18O2
Exact mass
206.1307
Mol weight
206.2808
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-inflammatory
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
hsa04370  VEGF signaling pathway  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Transporter inhibition: OAT2 [HSA:10864]
Drug interaction
Structure map
Antimigraines
Cyclooxygenase inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00126  Ibuprofen (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB16 Ibuprofen
      D00126  Ibuprofen (JP16/USP/INN)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC01 Ibuprofen
      D00126  Ibuprofen (JP16/USP/INN)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE01 Ibuprofen
      D00126  Ibuprofen (JP16/USP/INN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA13 Ibuprofen
      D00126  Ibuprofen (JP16/USP/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ibuprofen
    D00126  Ibuprofen (JP16/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Ibuprofen
    D00126  Ibuprofen (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1) [HSA:5742] [KO:K00509]
    Ibuprofen [ATC:C01EB16 G02CC01 M01AE01 M02AA13]
     D00126  Ibuprofen (JP16/USP/INN)
   cyclooxygenase-2 (COX-2) [HSA:5743] [KO:K11987]
    Ibuprofen [ATC:C01EB16 G02CC01 M01AE01 M02AA13]
     D00126  Ibuprofen (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
15687-27-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   O6a O    26.6164  -16.3136
            2   C6a C    25.4050  -17.0138
            3   C1c C    24.1928  -16.3148
            4   O6a O    25.4056  -18.4130
            5   C8y C    22.9815  -17.0150
            6   C8x C    21.7750  -16.3132
            7   C8x C    20.5638  -17.0135
            8   C8y C    20.5644  -18.4127
            9   C8x C    21.7765  -19.1116
            10  C8x C    22.9878  -18.4113
            11  C1b C    19.3530  -19.1128
            12  C1c C    18.1408  -18.4139
            13  C1a C    16.9295  -19.1141
            14  C1a C    18.1401  -17.0147
            15  C1a C    24.1920  -14.9103
BOND        15
            1     2   4 2
            2     3   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     8   9 1
            7     9  10 2
            8    10   5 1
            9     8  11 1
            10    1   2 1
            11   11  12 1
            12   12  13 1
            13    2   3 1
            14   12  14 1
            15    3  15 1

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