| Entry |
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| Name |
Cimetidine (JP16/USP/INN);
Tagamet (TN)
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| Product |
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| Generic |
CIMETIDINE (Apotex Corp), CIMETIDINE (Blenheim Pharmacal), CIMETIDINE (Bryant Ranch Prepack), CIMETIDINE (Bryant Ranch Prepack), GOOD SENSE HEARTBURN RELIEF (Bryant Ranch Prepack), CIMETIDINE (Bryant Ranch Prepack), CIMETIDINE (Dispensing Solutions), CIMETIDINE (Mylan Pharmaceuticals), CIMETIDINE (PD-Rx Pharmaceuticals), CIMETIDINE (Physicians Total Care), CIMETIDINE (Preferred Pharmaceuticals), CIMETIDINE (REMEDYREPACK), CIMETIDINE (REMEDYREPACK), CIMETIDINE (Rebel Distributors Corp), CIMETIDINE (STAT RX USA LLC), CIMETIDINE (STAT RX USA LLC), CIMETIDINE (Teva Pharmaceuticals USA) |
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| Formula |
C10H16N6S
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| Exact mass |
252.1157
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| Mol weight |
252.3392
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| Structure |
     |
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| Activity |
Antagonist [to histamine H2 receptors]
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
Transporter: SLC22A2 [HSA: 6582]
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| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576] (CYP3A [KO: K07424]), CYP2D6 [HSA: 1565], CYP2C9 [HSA: 1559], CYP1A2 [HSA: 1544]
Transporter inhibition: SLC22A2 [HSA: 6582], SLC22A3 [HSA: 6581], SLC47A1 [HSA: 55244], SCL47A2 [HSA: 146802]
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| Pathway map |
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| Structure map |
| Antiulcer drugs | | Histamine H2/H3 receptor agonists/antagonists |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2325 H2 blockers
D00295 Cimetidine (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BA H2-receptor antagonists
A02BA01 Cimetidine
D00295 Cimetidine (JP16/USP/INN)
USP drug classification [BR:br08302]
Gastrointestinal Agents
Histamine2 (H2) receptor Antagonists
Cimetidine
D00295 Cimetidine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H2-receptor [HSA:3274] [KO:K04150]
Cimetidine [ATC:A02BA01]
D00295 Cimetidine (JP16/USP/INN)
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| Other DBs |
CAS: 51481-61-9 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 17
1 C1b C 24.5609 -17.1206
2 S2a S 25.7722 -16.4242
3 C1b C 26.9833 -17.1206
4 C1b C 28.1944 -16.4242
5 N1b N 29.4055 -17.1206
6 C2c C 30.6226 -16.4242
7 N2b N 30.6226 -15.0201
8 N1b N 31.8337 -17.1206
9 C3b C 31.8337 -14.3237
10 C1a C 33.0449 -16.4242
11 N3a N 33.0598 -13.6286
12 C8y C 23.3693 -16.4301
13 N5x N 23.3693 -15.0301
14 C8x C 22.0378 -14.5975
15 N4x N 21.2149 -15.7301
16 C8y C 22.0378 -16.8627
17 C1a C 21.6042 -18.1971
BOND 17
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 2
7 6 8 1
8 7 9 1
9 8 10 1
10 9 11 3
11 1 12 1
12 12 13 1
13 13 14 2
14 14 15 1
15 15 16 1
16 12 16 2
17 16 17 1
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