KEGG   DRUG: D00659Help
Entry
D00659                      Drug                                   

Name
Azelastine hydrochloride (JP16/USAN);
Astelin (TN)
Product
  Generic
Formula
C22H24ClN3O. HCl
Exact mass
417.1375
Mol weight
418.3594
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-allergic;
Anti-asthmatic
Remark
Therapeutic category: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D00659  Azelastine hydrochloride (JP16/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC03 Azelastine
      D00659  Azelastine hydrochloride (JP16/USAN)
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX19 Azelastine
      D00659  Azelastine hydrochloride (JP16/USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX07 Azelastine
      D00659  Azelastine hydrochloride (JP16/USAN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Azelastine
    D00659  Azelastine hydrochloride (JP16/USAN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Azelastine
    D00659  Azelastine hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Azelastine [ATC:R01AC03 R06AX19 S01GX07]
      D00659  Azelastine hydrochloride (JP16/USAN)
BRITE hierarchy
Other DBs
CAS: 
79307-93-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   X   Cl   31.8050  -18.2160
            2   C1y C    27.4868  -20.1967
            3   C1x C    28.5815  -19.3346
            4   C1x C    29.9443  -19.6454
            5   N1y N    30.5451  -20.8963
            6   C1x C    27.4868  -21.6031
            7   C1x C    29.9452  -22.1612
            8   C1x C    28.5815  -22.4722
            9   N4y N    26.2277  -19.5856
            10  N5x N    26.2845  -18.1858
            11  C8y C    24.9979  -17.4984
            12  C8y C    23.7944  -18.2084
            13  C8y C    23.8074  -19.6086
            14  C8y C    25.0240  -20.2960
            15  C8x C    22.5778  -17.5209
            16  C8x C    21.3741  -18.2308
            17  C8x C    21.3171  -19.6311
            18  C8x C    22.6037  -20.3185
            19  C1b C    24.9845  -16.0905
            20  C8y C    26.2038  -15.4501
            21  C8x C    27.4009  -16.2066
            22  C8x C    28.7080  -15.5568
            23  C8y C    28.6938  -14.1607
            24  C8x C    27.4969  -13.4042
            25  C8x C    26.1898  -14.0539
            26  X   Cl   29.9185  -13.5170
            27  C1a C    31.9483  -20.9628
            28  O5x O    24.9670  -21.6792
BOND        30
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     2   9 1
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   12  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   13  18 2
            20   11  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   20  25 1
            28   23  26 1
            29    5  27 1
            30   14  28 2

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