| Entry |
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| Name |
Miconazole nitrate (JP16/USP);
MCZ;
Micatin (TN);
Monistat (TN)
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| Product |
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| Generic |
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| Formula |
C18H14Cl4N2O. HNO3
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| Exact mass |
476.9817
|
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| Mol weight |
479.1414
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| Structure |
     |
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| Activity |
|
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
ergosterol biosynthesis inhibitor
|
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| Target |
sterol 14alpha-demethylase ihibitor [KO: K05917] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP inhibition: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
 |
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| Structure map |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
252 Genital organ agents
2529 Others
D00882 Miconazole nitrate (JP16/USP)
26 Epidermides
265 Antiparasitic dermatosis agents
2655 Imidazoles
D00882 Miconazole nitrate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AB Antiinfectives and antiseptics for local oral treatment
A01AB09 Miconazole
D00882 Miconazole nitrate (JP16/USP)
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AC Imidazole derivatives
A07AC01 Miconazole
D00882 Miconazole nitrate (JP16/USP)
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AC Imidazole and triazole derivatives
D01AC02 Miconazole
D00882 Miconazole nitrate (JP16/USP)
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AF Imidazole derivatives
G01AF04 Miconazole
D00882 Miconazole nitrate (JP16/USP)
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AB Imidazole derivatives
J02AB01 Miconazole
D00882 Miconazole nitrate (JP16/USP)
S SENSORY ORGANS
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA13 Miconazole
D00882 Miconazole nitrate (JP16/USP)
USP drug classification [BR:br08302]
Antifungals
Antifungals, Systemic
Azole Antifungals
Miconazole
D00882 Miconazole nitrate (JP16/USP)
Antiinfectives [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
sterol 14alpha-demethylase inhibitor [KO:K05917]
Imidazoles
Miconazole [ATC:A01AB09 A07AC01 D01AC02 G01AF04 J02AB01 S02AA13]
D00882 Miconazole nitrate (JP16/USP)
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| Other DBs |
CAS: 22832-87-7 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 29
1 N2b N 27.6357 -20.3006 #+
2 O1b O 26.4299 -20.9879
3 O3a O 27.6298 -18.9026
4 O3a O 28.8414 -20.9996 #-
5 C8y C 26.1100 -13.3000
6 C8x C 26.1100 -14.7000
7 C8y C 27.3000 -15.4000
8 C8y C 28.5600 -14.7000
9 C8x C 28.5600 -13.3000
10 C8x C 27.3000 -12.6000
11 C1b C 29.7500 -15.4000
12 O2a O 31.0100 -14.7000
13 C1c C 32.2000 -15.4000
14 C1b C 33.3900 -14.7000
15 N4y N 34.6500 -15.4000
16 X Cl 27.3000 -16.8000
17 X Cl 24.9200 -12.6000
18 C8y C 32.2000 -16.8000
19 C8y C 31.0100 -17.5000
20 C8x C 31.0100 -18.9000
21 C8y C 32.2000 -19.6000
22 C8x C 33.3900 -18.9000
23 C8x C 33.3900 -17.5000
24 X Cl 29.8200 -16.8000
25 X Cl 32.2000 -21.0000
26 C8x C 34.6500 -16.8000
27 N5x N 35.9800 -17.2200
28 C8x C 36.7500 -16.1000
29 C8x C 35.9800 -14.9800
BOND 30
1 1 2 1
2 1 3 2
3 1 4 1
4 5 6 2
5 6 7 1
6 7 8 2
7 8 9 1
8 9 10 2
9 5 10 1
10 8 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 14 15 1
15 7 16 1
16 5 17 1
17 13 18 1
18 18 19 2
19 19 20 1
20 20 21 2
21 21 22 1
22 22 23 2
23 18 23 1
24 19 24 1
25 21 25 1
26 15 26 1
27 26 27 2
28 27 28 1
29 28 29 2
30 15 29 1
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