KEGG   DRUG: D01386Help
Entry
D01386                      Drug                                   
Name
Ephedrine hydrochloride (JP16/USP);
Ephedrine hydrochloride (TN)
Formula
C10H15NO. HCl
Exact mass
201.092
Mol weight
201.6931
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Bronchodilator [DS:H00079]
Remark
Therapeutic category: 
ATC code: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   222  Antitussives
    2221  Ephedrines and Ephedra herbs
     D01386  Ephedrine hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D01386  Ephedrine hydrochloride (JP16/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D01386  Ephedrine hydrochloride (JP16/USP)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D01386  Ephedrine hydrochloride (JP16/USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D01386  Ephedrine hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D01386  Ephedrine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Respiratory Tract Agents
  Bronchodilators, Sympathomimetic
   Ephedrine
    D01386  Ephedrine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Ephedrine [ATC:C01CA26 R01AA03 R01AB05 R03CA02 S01FB02]
      D01386  Ephedrine hydrochloride (JP16/USP)
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Ephedrine [ATC:C01CA26 R01AA03 R01AB05 R03CA02 S01FB02]
      D01386  Ephedrine hydrochloride (JP16/USP)
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Ephedrine [ATC:C01CA26 R01AA03 R01AB05 R03CA02 S01FB02]
      D01386  Ephedrine hydrochloride (JP16/USP)
    beta2-adrenergic receptor [HSA:154] [KO:K04142]
     Ephedrine [ATC:C01CA26 R01AA03 R01AB05 R03CA02 S01FB02]
      D01386  Ephedrine hydrochloride (JP16/USP)
    beta3-adrenergic receptor [HSA:155] [KO:K04143]
     Ephedrine [ATC:C01CA26 R01AA03 R01AB05 R03CA02 S01FB02]
      D01386  Ephedrine hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
50-98-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   C8x C    17.0325  -17.0009
            2   C8x C    17.0325  -18.4031
            3   C8x C    18.2497  -19.1041
            4   C8x C    19.4598  -18.4031
            5   C8y C    19.4598  -17.0009
            6   C8x C    18.2497  -16.2999
            7   C1c C    20.6653  -16.2999
            8   C1c C    21.8762  -16.9938
            9   N1b N    23.0872  -16.2927
            10  C1a C    24.2981  -16.9867
            11  O1a O    20.6609  -14.8977
            12  C1a C    21.8793  -18.3959
            13  X   Cl   29.1200  -17.5000
BOND        12
            1     6   1 1
            2     5   7 1
            3     1   2 2
            4     7   8 1
            5     2   3 1
            6     8   9 1
            7     3   4 2
            8     9  10 1
            9     4   5 1
            10    7  11 1 #Up
            11    5   6 2
            12    8  12 1 #Up

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