| Entry |
|
|---|
| Name |
Tizanidine (INN);
Sirdalud (TN) |
|---|
| Formula |
C9H8ClN5S
|
|---|
| Exact mass |
253.0189
|
|---|
| Mol weight |
253.7113
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
Musculo-skeletal system agent
DG02029 Muscle relaxant
DG01974 Centrally acting muscle relaxant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
| Product (DG00773): | D00776<JP/US> |
|
|---|
| Efficacy |
Muscle relaxant, alpha2-Adrenergic receptor agonist |
|---|
| Comment |
Imidazoline derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M03 MUSCLE RELAXANTS
M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
M03BX Other centrally acting agents
M03BX02 Tizanidine
D08611 Tizanidine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00773 Tizanidine
D08611 Tizanidine
Musculo-skeletal system agent
DG02029 Muscle relaxant
DG01974 Centrally acting muscle relaxant
DG00773 Tizanidine
D08611 Tizanidine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00773 Tizanidine
D08611 Tizanidine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D08611 Tizanidine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08611
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG00773 Tizanidine
Musculo-skeletal system agent
DG02029 Muscle relaxant
DG01974 Centrally acting muscle relaxant
DG00773 Tizanidine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00773 Tizanidine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 16
1 C8y C 23.1000 -18.6200
2 C8y C 23.1000 -17.2200
3 C8y C 21.8400 -19.3900
4 N5x N 24.1500 -19.6000
5 N1b N 24.2900 -16.5200
6 C8y C 21.8400 -16.5200
7 C8x C 20.6500 -18.6200
8 N5x N 22.1900 -20.7200
9 S2x S 23.5900 -20.7900
10 C2y C 25.4800 -17.2900
11 C8x C 20.6500 -17.2200
12 X Cl 21.8400 -15.1200
13 N1x N 26.8100 -16.8000
14 N2x N 25.4800 -18.6900
15 C1x C 27.6500 -17.9200
16 C1x C 26.8800 -19.0400
BOND 18
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1
10 6 11 1
11 6 12 1
12 10 13 1
13 10 14 2
14 13 15 1
15 14 16 1
16 7 11 2
17 8 9 1
18 15 16 1
|
|---|
