KEGG   DRUG: IsoflurophateHelp
Entry
D00043                      Drug                                   

Name
Isoflurophate;
Fluostigmine;
Floropryl (TN)
Formula
C6H14FO3P
Exact mass
184.0665
Mol weight
184.1457
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
  DG01594  Butyrylcholinesterase inhibitor
Remark
Same as: 
ATC code: 
Activity
Acetylcholinesterase inhibitor, Butyrylcholinesterase inhibitor (ophthalmic)
Comment
Reversible cholinesterase inhibitor
Target
ACHE [HSA:43] [KO:K01049];
BCHE [HSA:590] [KO:K01050]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB07 Fluostigmine
      D00043  Isoflurophate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Fluostigmine
     D00043  Isoflurophate
   butyrylcholinesterase (BChE)
    Fluostigmine
     D00043  Isoflurophate
BRITE hierarchy
Other DBs
CAS: 
55-91-4
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        11
            1   P1b P    23.2694  -15.1480
            2   O2b O    21.8252  -15.1480
            3   O2b O    23.2694  -16.5348
            4   O3b O    23.2183  -13.7549
            5   X   F    24.6114  -15.1545
            6   C1c C    20.3425  -15.1352
            7   C1c C    23.2694  -17.9279
            8   C1a C    19.6268  -14.0802
            9   C1a C    19.6715  -16.3495
            10  C1a C    22.0616  -18.6183
            11  C1a C    24.4709  -18.6183
BOND        10
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     6   8 1
            8     6   9 1
            9     7  10 1
            10    7  11 1

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