KEGG   DRUG: D00075Help
Entry
D00075                      Drug                                   

Name
Testosterone (JAN/USP);
Androderm (TN);
Androgel (TN);
Axiron (TN);
Striant (TN);
Testim (TN)
Product
  Generic
Formula
C19H28O2
Exact mass
288.2089
Mol weight
288.4244
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Androgen [DS:H00255]
Remark
Same as: 
ATC code: 
Drug group: 
Target
androgen receptor agonist [HSA:367] [KO:K08557]
  Pathway
hsa05200  Pathways in cancer
hsa05215  Prostate cancer  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03B ANDROGENS
    G03BA 3-oxoandrosten (4) derivatives
     G03BA03 Testosterone
      D00075  Testosterone (JAN/USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Androgens
   Testosterone
    D00075  Testosterone (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  61 Other agents for integumentary system
   D00075  Testosterone (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 1
  Inorganic and organic chemicals
   Testosterone
    D00075  Testosterone (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    androgen receptor
     Testosterone
      D00075  Testosterone (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Testosterone
    D00075  Testosterone (JAN/USP)
  CYP3A5
   Testosterone
    D00075  Testosterone (JAN/USP)
  CYP3A7
   Testosterone
    D00075  Testosterone (JAN/USP)
Phytochemicals used as drugs [BR:br08306]
 Terpenoids
  Triterpenoids (C30) and related compounds
   Sterols and steroids
    D00075  Testosterone (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
58-22-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1x C    28.5514  -18.0276
            2   C5x C    28.5514  -19.4309
            3   C2x C    29.7441  -20.1325
            4   C2y C    31.0070  -19.4309
            5   C1z C    31.0070  -18.0276
            6   C1x C    29.7441  -17.3260
            7   C1x C    32.1998  -20.1325
            8   C1x C    33.3925  -19.4309
            9   C1y C    33.3925  -18.0276
            10  C1y C    32.1998  -17.3260
            11  C1y C    34.6554  -17.3260
            12  C1z C    34.6554  -15.9228
            13  C1x C    33.3925  -15.2212
            14  C1x C    32.1998  -15.9228
            15  O5x O    27.3586  -20.1325
            16  C1a C    34.6554  -14.5195
            17  C1a C    31.0070  -16.6244
            18  C1x C    37.0803  -17.3260
            19  C1x C    37.0803  -15.9228
            20  C1y C    35.8678  -15.2228
            21  O1a O    35.8678  -13.8228
BOND        24
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17    2  15 2
            18   12  16 1 #Up
            19    5  17 1 #Up
            20   11  18 1
            21   18  19 1
            22   19  20 1
            23   12  20 1
            24   20  21 1 #Up

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