KEGG   DRUG: TestosteroneHelp
Entry
D00075                      Drug                                   

Name
Testosterone (JAN/USP);
Androderm (TN);
Androgel (TN);
Axiron (TN);
Striant (TN);
Testim (TN)
Product
  Generic
  Other
Formula
C19H28O2
Exact mass
288.2089
Mol weight
288.4244
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01590  Androgen receptor agonist
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Androgen
Target
androgen receptor [HSA:367] [KO:K08557]
  Pathway
Pathways in cancer
Prostate cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03B ANDROGENS
    G03BA 3-oxoandrosten (4) derivatives
     G03BA03 Testosterone
      D00075  Testosterone (JAN/USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Androgens
   Testosterone
    D00075  Testosterone (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  31 Other drugs for  urogenital organs and anus
   D00075  Testosterone (JAN/USP)
 Agents for integumentary system
  61 Other agents for integumentary system
   D00075  Testosterone (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Testosterone
    D00075  Testosterone (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    androgen receptor
     Testosterone
      D00075  Testosterone (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Testosterone
    D00075  Testosterone (JAN/USP)
  CYP3A5
   Testosterone
    D00075  Testosterone (JAN/USP)
  CYP3A7
   Testosterone
    D00075  Testosterone (JAN/USP)
 Transporter inhibitors
  SLC22A2
   Testosterone
    D00075  Testosterone (JAN/USP)
Phytochemicals used as drugs [BR:br08306]
 Terpenoids
  Triterpenoids (C30) and related compounds
   Sterols and steroids
    D00075  Testosterone (JAN/USP)
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00075
BRITE hierarchy
Other DBs
CAS: 
58-22-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1x C    28.5514  -18.0276
            2   C5x C    28.5514  -19.4309
            3   C2x C    29.7441  -20.1325
            4   C2y C    31.0070  -19.4309
            5   C1z C    31.0070  -18.0276
            6   C1x C    29.7441  -17.3260
            7   C1x C    32.1998  -20.1325
            8   C1x C    33.3925  -19.4309
            9   C1y C    33.3925  -18.0276
            10  C1y C    32.1998  -17.3260
            11  C1y C    34.6554  -17.3260
            12  C1z C    34.6554  -15.9228
            13  C1x C    33.3925  -15.2212
            14  C1x C    32.1998  -15.9228
            15  O5x O    27.3586  -20.1325
            16  C1a C    34.6554  -14.5195
            17  C1a C    31.0070  -16.6244
            18  C1x C    37.0803  -17.3260
            19  C1x C    37.0803  -15.9228
            20  C1y C    35.8678  -15.2228
            21  O1a O    35.8678  -13.8228
BOND        24
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17    2  15 2
            18   12  16 1 #Up
            19    5  17 1 #Up
            20   11  18 1
            21   18  19 1
            22   19  20 1
            23   12  20 1
            24   20  21 1 #Up

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