KEGG   DRUG: InsulinHelp
Entry
D00085                      Drug                                   

Name
Insulin (JAN/USP)
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr
(Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analogue
  DG01802  Human insulin
   DG01798  Human insulin, fast-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Same as: 
Activity
Antidiabetic, Insulin receptor agonist
Comment
Pancreas hormone
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
Adherens junction
Insulin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin
      D00085  Insulin (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP1A2
   Insulin
    D00085  Insulin (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
9004-10-8
PubChem: 
ChEBI: 
DrugBank: 
NIKKAJI: 

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