KEGG   DRUG: InsulinHelp
Entry
D00085                      Drug                                   

Name
Insulin (JAN/USP)
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr
(Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analog
  DG01802  Human insulin
   DG01798  Human insulin, fast-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Same as: C00723
Efficacy
Antidiabetic, Insulin receptor agonist
Comment
Pancreas hormone
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
hsa04520  Adherens junction
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04960  Aldosterone-regulated sodium reabsorption
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    INSR (CD220)
     D00085  Insulin (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 9004-10-8
PubChem: 7847153
ChEBI: 5931
DrugBank: DB00030
NIKKAJI: J2.730.443E

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