KEGG   DRUG: D00095Help
Entry
D00095                      Drug                                   

Name
Adrenaline (JP16);
Epinephrine (USP/INN);
Adrenalin (TN);
Auvi-q (TN);
Epipen (TN)
Product
  Generic
  Other
Formula
C9H13NO3
Exact mass
183.0895
Mol weight
183.2044
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adrenergic [vasoconstrictor]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D00095  Adrenaline (JP16); Epinephrine (USP/INN)
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D00095  Adrenaline (JP16); Epinephrine (USP/INN)
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D00095  Adrenaline (JP16); Epinephrine (USP/INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D00095  Adrenaline (JP16); Epinephrine (USP/INN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D00095  Adrenaline (JP16); Epinephrine (USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D00095  Adrenaline (JP16); Epinephrine (USP/INN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Epinephrine
    D00095  Adrenaline (JP16); Epinephrine (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2451  Epinephrines
     D00095  Adrenaline (JP16); Epinephrine (USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 2
  Inorganic and organic chemicals
   Adrenaline (Epinephrine)
    D00095  Adrenaline (JP16); Epinephrine (USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Epinephrine
      D00095  Epinephrine (USP/INN)
    alpha2-adrenergic receptor
     Epinephrine
      D00095  Epinephrine (USP/INN)
    beta1-adrenergic receptor
     Epinephrine
      D00095  Epinephrine (USP/INN)
    beta2-adrenergic receptor
     Epinephrine
      D00095  Epinephrine (USP/INN)
    beta3-adrenergic receptor
     Epinephrine
      D00095  Epinephrine (USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00095  Adrenaline
  D00095  Adrenaline solution
  D00095  Adrenaline injection
BRITE hierarchy
Other DBs
CAS: 
51-43-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   C8y C    21.2028  -17.0133
            2   C8x C    21.2028  -18.4284
            3   C8x C    19.9857  -16.3144
            4   C1c C    22.4083  -16.3144
            5   C8x C    19.9857  -19.1389
            6   C8y C    18.7742  -17.0133
            7   C1b C    23.6196  -17.0075
            8   O1a O    22.4083  -14.9168
            9   C8y C    18.7742  -18.4284
            10  N1b N    24.8191  -16.3087
            11  O1a O    17.5630  -19.1156
            12  O1a O    17.5677  -16.3165
            13  C1a C    26.0284  -17.0006
BOND        13
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     3   6 2
            5     4   7 1
            6     4   8 1 #Up
            7     5   9 2
            8     7  10 1
            9     9  11 1
            10    6   9 1
            11    6  12 1
            12    1   2 2
            13   10  13 1

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