KEGG   DRUG: D00101Help
Entry
D00101                      Drug                                   

Name
Vasopressin (JP16/USP);
Pitressin (TN)
Product
  Other
Formula
(C46H65N15O12S2)m. (C46H65N13O12S2)n
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hormone [antidiuretic] [DS:H00253]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Components: Argipressin tannate [DR:D02983], Lypressin [DR:D00366]
Target
arginine vasopressin receptor 1A (AVPR1A) agonist [HSA:552] [KO:K04226];
arginine vasopressin receptor 1B (AVPR1B) agonist [HSA:553] [KO:K04227];
arginine vasopressin receptor 2 (AVPR2) agonist [HSA:554] [KO:K04228]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01B POSTERIOR PITUITARY LOBE HORMONES
    H01BA Vasopressin and analogues
     H01BA01 Vasopressin
      D00101  Vasopressin (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   241  Pituitary hormone preparations
    2414  Posterior pituitary hormones
     D00101  Vasopressin (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Vasopressin
    arginine vasopressin receptor 1A (AVPR1A)
     Vasopressin
      D00101  Vasopressin (JP16/USP)
    arginine vasopressin receptor 1B (AVPR1B)
     Vasopressin
      D00101  Vasopressin (JP16/USP)
    arginine vasopressin receptor 2 (AVPR2)
     Vasopressin
      D00101  Vasopressin (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00101  Vasopressin injection
BRITE hierarchy
Other DBs
CAS: 
11000-17-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        148
            1   N1y N     6.3499  -21.3894
            2   C1y C     6.7690  -22.6470
            3   C5a C     6.3499  -20.1319
            4   C1x C     5.0225  -21.4593
            5   C5a C     7.8869  -23.3456
            6   C1x C     5.7211  -23.4854
            7   C1y C     7.4677  -19.4333
            8   O5a O     5.1622  -19.4333
            9   C1x C     4.6033  -22.7168
            10  N1b N     9.0047  -22.6470
            11  O5a O     7.8869  -24.6032
            12  N1x N     7.4677  -18.1058
            13  C1x C     8.5855  -20.1319
            14  C1c C    10.1924  -23.3456
            15  C5x C     8.5855  -17.4771
            16  S3x S     9.7733  -19.4333
            17  C5a C    10.1924  -24.6032
            18  C1b C    11.3102  -22.6470
            19  C1y C     8.5855  -16.1497
            20  O5x O     9.7733  -18.1058
            21  S3x S    10.8910  -20.1319
            22  N1b N    11.3102  -25.3019
            23  O5a O     9.0047  -25.3019
            24  C1b C    12.4281  -23.3456
            25  N1x N     7.4677  -15.4510
            26  C1b C     9.7733  -15.4510
            27  C1x C    12.0089  -19.4333
            28  C1b C    12.4281  -24.6032
            29  C1b C    13.6157  -22.6470
            30  C5x C     7.4677  -14.1934
            31  C5a C    10.8910  -16.1497
            32  C1y C    13.1965  -20.1319
            33  N1b N    14.7336  -23.3456
            34  C1y C     9.4937  -13.4250
            35  O5x O     6.3499  -13.4949
            36  N1a N    12.0089  -15.4510
            37  O5a O    10.8910  -17.4771
            38  C5x C    14.3144  -19.4333
            39  N1a N    13.1965  -21.3894
            40  N1x N    11.3102  -14.1934
            41  C1b C     9.4937  -11.7482
            42  N1x N    15.4322  -20.1319
            43  O5x O    14.3144  -18.1058
            44  C5x C    13.1965  -13.4250
            45  C1b C     8.3760  -11.0496
            46  C1y C    16.6198  -19.4333
            47  C1y C    15.5021  -14.1934
            48  O5x O    13.1965  -12.0976
            49  C5a C     7.1882  -11.6784
            50  C1b C    17.7377  -20.1319
            51  C5x C    16.6198  -18.1058
            52  C1b C    16.7596  -13.4949
            53  N1x N    15.5021  -17.4771
            54  N1a N     6.0704  -11.0496
            55  O5a O     7.1882  -13.0058
            56  C8y C    18.8556  -19.4333
            57  O5x O    17.7377  -17.4771
            58  C8y C    17.9473  -14.1236
            59  C8x C    19.9733  -20.0620
            60  C8x C    18.8556  -18.1058
            61  C8x C    17.9473  -15.4510
            62  C8x C    19.0651  -13.4250
            63  C8x C    21.1610  -19.4333
            64  C8x C    19.9733  -17.4771
            65  C8x C    19.0651  -16.0798
            66  C8x C    20.1830  -14.1236
            67  C8y C    21.1610  -18.1058
            68  C8x C    20.1830  -15.4510
            69  O1a O    22.2789  -17.4771
            70  C2c C    15.9212  -22.5772
            71  N1a N    17.1788  -23.3456
            72  N2a N    15.9212  -21.2498
            73  C5a C    13.6856  -25.3716
            74  N1a N    14.8732  -24.6731
            75  O5a O    13.6856  -26.7689
            76  N1y N    28.1699  -21.0164
            77  C1y C    28.5903  -22.2778
            78  C5a C    28.1699  -19.7550
            79  C1x C    26.8383  -21.0865
            80  C5a C    29.7116  -22.9786
            81  C1x C    27.5391  -23.1188
            82  C1y C    29.2911  -19.0542
            83  O5a O    26.9785  -19.0542
            84  C1x C    26.4179  -22.3479
            85  N1b N    30.8329  -22.2778
            86  O5a O    29.7116  -24.2401
            87  N1x N    29.2911  -17.7227
            88  C1x C    30.4124  -19.7550
            89  C1c C    31.9542  -22.9786
            90  C5x C    30.4124  -17.0919
            91  S3x S    31.5337  -19.0542
            92  C5a C    31.9542  -24.2401
            93  C1b C    33.0754  -22.2778
            94  C1y C    30.4124  -15.8305
            95  O5x O    31.5337  -17.7227
            96  S3x S    32.6549  -19.7550
            97  N1b N    33.0754  -24.9409
            98  O5a O    30.8329  -24.9409
            99  C1b C    34.1967  -22.9786
            100 N1x N    29.2911  -15.1297
            101 C1b C    31.5337  -15.1297
            102 C1x C    33.7762  -19.0542
            103 C1b C    34.1967  -24.2401
            104 C1b C    35.3881  -22.2778
            105 C5x C    29.2911  -13.8683
            106 C5a C    32.6549  -15.8305
            107 C1y C    34.9676  -19.7550
            108 C1b C    36.5093  -22.9786
            109 C1y C    31.3234  -13.0974
            110 O5x O    28.1699  -13.1675
            111 N1a N    33.7762  -15.1297
            112 O5a O    32.6549  -17.0919
            113 C5x C    36.0888  -19.0542
            114 N1a N    34.9676  -21.0164
            115 N1x N    33.0754  -13.8683
            116 C1b C    31.3234  -11.4155
            117 N1x N    37.2101  -19.7550
            118 O5x O    36.0888  -17.7227
            119 C5x C    34.9676  -13.0974
            120 C1b C    30.2022  -10.7147
            121 C1y C    38.4015  -19.0542
            122 C1y C    37.2802  -13.8683
            123 O5x O    34.9676  -11.7659
            124 C5a C    29.0108  -11.3454
            125 C1b C    39.5228  -19.7550
            126 C5x C    38.4015  -17.7227
            127 C1b C    38.5416  -13.1675
            128 N1x N    37.2802  -17.0919
            129 N1a N    27.8895  -10.7147
            130 O5a O    29.0108  -12.6769
            131 C8y C    40.6440  -19.0542
            132 O5x O    39.5228  -17.0919
            133 C8y C    39.7330  -13.7982
            134 C8x C    41.7653  -19.6849
            135 C8x C    40.6440  -17.7227
            136 C8x C    39.7330  -15.1297
            137 C8x C    40.8543  -13.0974
            138 C8x C    42.9567  -19.0542
            139 C8x C    41.7653  -17.0919
            140 C8x C    40.8543  -15.7604
            141 C8x C    41.9755  -13.7982
            142 C8y C    42.9567  -17.7227
            143 C8x C    41.9755  -15.1297
            144 O1a O    44.0779  -17.0919
            145 N1a N    37.7007  -22.2078
            146 C5a C    35.4581  -25.0109
            147 N1a N    36.6495  -24.3101
            148 O5a O    35.4581  -26.4125
BOND        154
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    7  12 1
            12    7  13 1
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   16  21 1
            21   17  22 1
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   19  26 1
            26   21  27 1
            27   22  28 1
            28   24  29 1
            29   25  30 1
            30   26  31 1
            31   27  32 1
            32   29  33 1
            33   30  34 1
            34   30  35 2
            35   31  36 1
            36   31  37 2
            37   32  38 1
            38   32  39 1
            39   34  40 1
            40   34  41 1
            41   38  42 1
            42   38  43 2
            43   40  44 1
            44   41  45 1
            45   42  46 1
            46   44  47 1
            47   44  48 2
            48   45  49 1
            49   46  50 1
            50   46  51 1
            51   47  52 1
            52   47  53 1
            53   49  54 1
            54   49  55 2
            55   50  56 1
            56   51  57 2
            57   52  58 1
            58   56  59 2
            59   56  60 1
            60   58  61 2
            61   58  62 1
            62   59  63 1
            63   60  64 2
            64   61  65 1
            65   62  66 2
            66   63  67 2
            67   65  68 2
            68   67  69 1
            69    6   9 1
            70   51  53 1
            71   64  67 1
            72   66  68 1
            73   33  70 1
            74   70  71 1
            75   70  72 2
            76   28  73 1
            77   73  74 1
            78   73  75 2
            79   76  77 1
            80   76  78 1
            81   76  79 1
            82   77  80 1
            83   77  81 1
            84   78  82 1
            85   78  83 2
            86   79  84 1
            87   80  85 1
            88   80  86 2
            89   82  87 1
            90   82  88 1
            91   85  89 1
            92   87  90 1
            93   88  91 1
            94   89  92 1
            95   89  93 1
            96   90  94 1
            97   90  95 2
            98   91  96 1
            99   92  97 1
            100  92  98 2
            101  93  99 1
            102  94 100 1
            103  94 101 1
            104  96 102 1
            105  97 103 1
            106  99 104 1
            107 100 105 1
            108 101 106 1
            109 102 107 1
            110 104 108 1
            111 105 109 1
            112 105 110 2
            113 106 111 1
            114 106 112 2
            115 107 113 1
            116 107 114 1
            117 109 115 1
            118 109 116 1
            119 113 117 1
            120 113 118 2
            121 115 119 1
            122 116 120 1
            123 117 121 1
            124 119 122 1
            125 119 123 2
            126 120 124 1
            127 121 125 1
            128 121 126 1
            129 122 127 1
            130 122 128 1
            131 124 129 1
            132 124 130 2
            133 125 131 1
            134 126 132 2
            135 127 133 1
            136 131 134 2
            137 131 135 1
            138 133 136 2
            139 133 137 1
            140 134 138 1
            141 135 139 2
            142 136 140 1
            143 137 141 2
            144 138 142 2
            145 140 143 2
            146 142 144 1
            147  81  84 1
            148 126 128 1
            149 139 142 1
            150 141 143 1
            151 108 145 1
            152 103 146 1
            153 146 147 1
            154 146 148 2
BRACKET     1     3.9900  -27.4400    3.9900   -9.9400
            1    23.5900   -9.9400   23.5900  -27.4400
            1  m
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16
            1   17  18  19  20  21  22  23  24  25  26  27  28  29  30  31  32
            1   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            1   49  50  51  52  53  54  55  56  57  58  59  60  61  62  63  64
            1   65  66  67  68  69  70  71  72  73  74  75
 REPEAT    1
            2    25.6200  -27.3700   25.6200   -9.9400
            2    45.4300   -9.9400   45.4300  -27.3700
            2  n
 ORIGINAL  2   76  77  78  79  80  81  82  83  84  85  86  87  88  89  90  91
            2   92  93  94  95  96  97  98  99 100 101 102 103 104 105 106 107
            2  108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123
            2  124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139
            2  140 141 142 143 144 145 146 147 148
 REPEAT    2

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