| Entry |
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| Name |
Chloramphenicol (JP16/USP/INN);
CP;
Amphicol (TN);
Chloromycetin (TN);
Econochlor (TN)
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| Formula |
C11H12Cl2N2O5
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| Exact mass |
322.0123
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| Mol weight |
323.1294
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| Structure |
     |
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| Source |
Streptomyces venezuelae [TAX: 54571], Streptomyces omiyaensis [TAX: 68247]
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| Activity |
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
Natural product
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| Target |
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO: K01980] |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]
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| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577], CYP3A7 [HSA: 1551]
 |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1317 Ophthalmic antibiotics
D00104 Chloramphenicol (JP16/USP/INN)
132 Otic and nasal agents
1325 Otolaryngologic antibiotics
D00104 Chloramphenicol (JP16/USP/INN)
2 Agents affecting individual organs
25 Urogenital and anal organ agents
252 Genital organ agents
2521 Antibiotics
D00104 Chloramphenicol (JP16/USP/INN)
26 Epidermides
263 Suppurative dermatosis agents
2634 Antibiotics for external use
D00104 Chloramphenicol (JP16/USP/INN)
6 Agents against pathologic organisms and parasites
61 Antibiotics
615 Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
6151 Chloramphenicols
D00104 Chloramphenicol (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D06A ANTIBIOTICS FOR TOPICAL USE
D06AX Other antibiotics for topical use
D06AX02 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF03 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AA Antibiotics
G01AA05 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01B AMPHENICOLS
J01BA Amphenicols
J01BA01 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA01 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA01 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03A ANTIINFECTIVES
S03AA Antiinfectives
S03AA08 Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Miscellaneous Antibacterials
Chloramphenicol
D00104 Chloramphenicol (JP16/USP/INN)
Antiinfectives [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
Amphenicols
Chloramphenicol [ATC:D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08]
D00104 Chloramphenicol (JP16/USP/INN)
 |
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| Other DBs |
CAS: 56-75-7 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 20
1 C8y C 21.4200 -17.2900
2 C1c C 21.4200 -18.6900
3 C8x C 20.2300 -16.5900
4 C8x C 22.6800 -16.5900
5 C1c C 22.6100 -19.3900
6 O1a O 20.2300 -19.3900
7 C8x C 20.2300 -15.1900
8 C8x C 22.6800 -15.1900
9 N1b N 23.8700 -18.6900
10 C1b C 22.6100 -20.7900
11 C8y C 21.4200 -14.4900
12 C5a C 25.0600 -19.3900
13 O1a O 21.4200 -21.4900
14 N2b N 21.4200 -13.0900 #+
15 C1c C 26.2500 -18.6900
16 O5a O 25.0600 -20.7900
17 O3a O 20.2300 -12.3900
18 O3a O 22.6100 -12.3900 #-
19 X Cl 27.5100 -19.3900
20 X Cl 26.2500 -17.2900
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 4 8 2
8 5 9 1
9 5 10 1
10 7 11 2
11 9 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 12 16 2
16 14 17 2
17 14 18 1
18 15 19 1
19 15 20 1
20 8 11 1
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