KEGG   DRUG: EstradiolHelp
Entry
D00105                      Drug                                   

Name
Estradiol (JAN/USP/INN);
Climara (TN);
Divigel (TN);
Estrace (TN);
Estraderm (TN);
Estrasorb (TN);
Estring (TN);
Estrogel (TN);
Innofem (TN);
Vagifem (TN);
Vivelle (TN)
Product
ESTROGEL (ASCEND Therapeutics US), ESTROGEL (ASCEND Therapeutics US), ESTRADIOL TRANSDERMAL SYSTEM (Alvogen), CLIMARA (Bayer HealthCare Pharmaceuticals), MENOSTAR (Bayer HealthCare Pharmaceuticals), ELESTRIN (Jazz Pharmaceuticals Commercial Corp.), ELESTRIN (Jazz Pharmaceuticals Commercial Corp.), VIVELLE-DOT (Novartis Pharmaceuticals Corporation), MINIVELLE (Noven Therapeutics), VAGIFEM (Novo Nordisk), EVAMIST (Paddock Laboratories), ESTRING (Pharmacia and Upjohn Company LLC), VIVELLE DOT (Physicians Total Care), DIVIGEL (Physicians Total Care), ESTRING (Physicians Total Care), VAGIFEM (Physicians Total Care), EVAMIST (Physicians Total Care), EVAMIST (Ther-Rx Corporation), ESTRING (U.S. Pharmaceuticals), DIVIGEL (Upsher-Smith Laboratories), DIVIGEL (Vertical Pharmaceuticals), ELESTRIN (MEDA Pharmaceuticals), ALORA (Actavis Pharma)
  Generic
ESTRADIOL (A-S Medication Solutions), ESTRADIOL (A-S Medication Solutions), ESTRADIOL (Aidarex Pharmaceuticals LLC), ESTRACE (Allergan), YUVAFEM (Amneal Pharmaceuticals LLC), ESTRADIOL (Amneal Pharmaceuticals of New York), ESTRADIOL (AvPAK), ESTRADIOL (Avera McKennan Hospital), ESTRADIOL (Avera McKennan Hospital), ESTRADIOL (Avera McKennan Hospital), ESTRADIOL (Barr Laboratories), ESTRADIOL (Blenheim Pharmacal), ESTRADIOL (Bryant Ranch Prepack), ESTRADIOL (Bryant Ranch Prepack), ESTRADIOL (Bryant Ranch Prepack), ESTRADIOL (Bryant Ranch Prepack), ESTRADIOL (Cardinal Health), ESTRADIOL (DirectRX), ESTRADIOL (DirectRX), ESTRADIOL (Golden State Medical Supply), ESTRADIOL (Heritage Pharmaceuticals), ESTRADIOL (KAISER FOUNDATION HOSPITALS), ESTRADIOL (KAISER FOUNDATION HOSPITALS), ESTRADIOL (KAISER FOUNDATION HOSPITALS), ESTRADIOL (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ESTRADIOL (Mylan Pharmaceuticals), ESTRADIOL (Mylan Pharmaceuticals), ESTRADIOL (Mylan Pharmaceuticals), ESTRADIOL (PD-Rx Pharmaceuticals), ESTRADIOL (PD-Rx Pharmaceuticals), ESTRADIOL (PD-Rx Pharmaceuticals), ESTRADIOL (PD-Rx Pharmaceuticals), ESTRADIOL (PD-Rx Pharmaceuticals), ESTRADIOL (Physicians Total Care), ESTRADIOL (Physicians Total Care), ESTRADIOL (Preferred Pharmaceuticals), ESTRADIOL (Preferred Pharmaceuticals), ESTRADIOL (Proficient Rx LP), ESTRADIOL (ReadyMeds), ESTRADIOL (Rebel Distributors Corp), ESTRADIOL (STAT Rx USA LLC), ESTRADIOL (Sandoz), ESTRADIOL (Stat Rx USA), ESTRACE (Warner Chilcott (US)), ESTRADIOL (Watson Laboratories)
  Other
Formula
C18H24O2
Exact mass
272.1776
Mol weight
272.382
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01584  Estrogen receptor agonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Estrogen
Target
estrogen receptor 1 [HSA:2099] [KO:K08550];
estrogen receptor 2 [HSA:2100] [KO:K08551]
  Pathway
Endocrine and other factor-regulated calcium reabsorption
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1B1 [HSA:1545], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Osteoporosis drugs
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03C ESTROGENS
    G03CA Natural and semisynthetic estrogens, plain
     G03CA03 Estradiol
      D00105  Estradiol (JAN/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Estrogens
   Estradiol
    D00105  Estradiol (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2473  Estradiols
     D00105  Estradiol (JAN/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Drugs for women
  51 Other drugs for women
   D00105  Estradiol (JAN/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Estradiol
    D00105  Estradiol (JAN/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Estradiol
    D00105  Estradiol (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   Estrogen receptor
    estrogen receptor 1
     Estradiol
      D00105  Estradiol (JAN/USP/INN)
    estrogen receptor 2
     Estradiol
      D00105  Estradiol (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Estradiol
    D00105  Estradiol (JAN/USP/INN)
  CYP1B1
   Estradiol
    D00105  Estradiol (JAN/USP/INN)
  CYP3A4
   Estradiol
    D00105  Estradiol (JAN/USP/INN)
Osteoporosis drugs [br08368.html]
 D00105
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00105
BRITE hierarchy
Other DBs
CAS: 
50-28-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8x C    19.0779  -11.8363
            2   C8y C    19.0779  -13.2006
            3   C8x C    20.2594  -13.8828
            4   C8y C    21.4411  -13.2006
            5   C8y C    21.4411  -11.8363
            6   C8x C    20.2594  -11.1541
            7   C1x C    22.6226  -13.8828
            8   C1x C    23.8041  -13.2006
            9   C1y C    23.8041  -11.8363
            10  C1y C    22.6226  -11.1541
            11  C1y C    24.9857  -11.1541
            12  C1z C    24.9857   -9.7898
            13  C1x C    23.8041   -9.1076
            14  C1x C    22.6226   -9.7898
            15  C1x C    27.3487  -11.1541
            16  C1x C    27.3487   -9.7898
            17  C1y C    26.1672   -9.1076
            18  O1a O    26.1672   -7.7433
            19  O1a O    17.8964  -13.8828
            20  C1a C    24.9857   -8.4255
BOND        23
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22    2  19 1
            23   12  20 1 #Up

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