KEGG   DRUG: D00106Help
Entry
D00106                      Drug                                   

Name
Epoprostenol (USAN/INN);
Prostaglandin I2;
Prostacyclin;
Epoprostenol (TN)
Product
  Generic
Formula
C20H32O5
Exact mass
352.225
Mol weight
352.4651
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibitor [platelet]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Eicosanoids
Target
prostaglandin I2 receptor agonist [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Eicosanoids
Antithrombosis agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC09 Epoprostenol
      D00106  Epoprostenol (USAN/INN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Epoprostenol
    D00106  Epoprostenol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    prostaglandin I2 receptor
     Epoprostenol
      D00106  Epoprostenol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
35121-78-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    23.9400  -30.3100
            2   C1y C    22.6100  -29.8900
            3   C1y C    23.9400  -31.7100
            4   C1x C    24.6400  -29.0500
            5   O2x O    22.6100  -28.4200
            6   C1x C    21.8400  -31.0100
            7   C1y C    22.6800  -32.1300
            8   C2b C    25.1300  -32.4100
            9   C2y C    23.9400  -27.7900
            10  O1a O    22.1900  -33.4600
            11  C2b C    26.3200  -31.7100
            12  C2b C    25.1300  -27.0900
            13  C1c C    27.5100  -32.4100
            14  C1b C    28.7700  -31.7100
            15  O1a O    27.5100  -33.7400
            16  C1b C    29.9600  -32.4100
            17  C1b C    31.1500  -31.7100
            18  C1b C    32.3400  -32.4100
            19  C1a C    33.5300  -31.7100
            20  C1b C    25.2000  -25.6900
            21  C1b C    26.3900  -24.9900
            22  C1b C    26.3900  -23.5900
            23  C6a C    27.5800  -22.8900
            24  O6a O    28.8400  -23.5900
            25  O6a O    27.5800  -21.4900
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1 #Down
            5     2   6 1
            6     3   7 1
            7     3   8 1 #Up
            8     4   9 1
            9     7  10 1 #Down
            10    8  11 2
            11    9  12 2
            12   11  13 1
            13   13  14 1
            14   13  15 1 #Down
            15   14  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19    5   9 1
            20    6   7 1
            21   12  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 2
            26   23  25 1

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