KEGG   DRUG: EpoprostenolHelp
Entry
D00106                      Drug                                   

Name
Epoprostenol (USAN/INN);
Prostaglandin I2;
Prostacyclin;
Epoprostenol (TN)
Product
  Generic
Formula
C20H32O5
Exact mass
352.225
Mol weight
352.4651
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01810  Prostacycline derivative
Unclassified
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Platelet aggregation inhibitor, Prostaglandin I2 receptor agonist
Comment
Eicosanoids, Prostacycline derivative
Target
prostaglandin I2 receptor [HSA:5739] [KO:K04263]
  Pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
Eicosanoids
Antithrombosis agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC09 Epoprostenol
      D00106  Epoprostenol (USAN/INN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Epoprostenol
    D00106  Epoprostenol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    prostaglandin I2 receptor
     Epoprostenol
      D00106  Epoprostenol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
35121-78-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    23.9400  -30.3100
            2   C1y C    22.6100  -29.8900
            3   C1y C    23.9400  -31.7100
            4   C1x C    24.6400  -29.0500
            5   O2x O    22.6100  -28.4200
            6   C1x C    21.8400  -31.0100
            7   C1y C    22.6800  -32.1300
            8   C2b C    25.1300  -32.4100
            9   C2y C    23.9400  -27.7900
            10  O1a O    22.1900  -33.4600
            11  C2b C    26.3200  -31.7100
            12  C2b C    25.1300  -27.0900
            13  C1c C    27.5100  -32.4100
            14  C1b C    28.7700  -31.7100
            15  O1a O    27.5100  -33.7400
            16  C1b C    29.9600  -32.4100
            17  C1b C    31.1500  -31.7100
            18  C1b C    32.3400  -32.4100
            19  C1a C    33.5300  -31.7100
            20  C1b C    25.2000  -25.6900
            21  C1b C    26.3900  -24.9900
            22  C1b C    26.3900  -23.5900
            23  C6a C    27.5800  -22.8900
            24  O6a O    28.8400  -23.5900
            25  O6a O    27.5800  -21.4900
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1 #Down
            5     2   6 1
            6     3   7 1
            7     3   8 1 #Up
            8     4   9 1
            9     7  10 1 #Down
            10    8  11 2
            11    9  12 2
            12   11  13 1
            13   13  14 1
            14   13  15 1 #Down
            15   14  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19    5   9 1
            20    6   7 1
            21   12  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 2
            26   23  25 1

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