KEGG   DRUG: TacrolimusHelp
Entry
D00107                      Drug                                   

Name
Tacrolimus (USAN/INN);
Tacrolimus hydrate (JP17);
Prograf (TN);
Protopic (TN)
Product
  Generic
TACROLIMUS (A-S Medication Solutions), TACROLIMUS (Accord Healthcare), TACROLIMUS (American Health Packaging), TACROLIMUS (BionPharma Inc.,), TACROLIMUS (Bryant Ranch Prepack), TACROLIMUS (Cardinal Health), TACROLIMUS (Cardinal Health), TACROLIMUS (Cardinal Health), TACROLIMUS (Cardinal Health), TACROLIMUS (Cardinal Health), TACROLIMUS (Dr. Reddy's Laboratories Limited), TACROLIMUS (E. Fougera & Co. a division of Fougera Pharmaceuticals), TACROLIMUS (Golden State Medical Supply), TACROLIMUS (Ingenus Pharmaceuticals), TACROLIMUS (KAISER FOUNDATION HOSPITALS), TACROLIMUS (Kremers Urban Pharmaceuticals), TACROLIMUS (Major Pharmaceuticals), TACROLIMUS (Mylan Institutional), TACROLIMUS (Mylan Pharmaceuticals), HECORIA (Novartis Pharmaceuticals Corporation), TACROLIMUS (Sandoz), TACROLIMUS (Sandoz), TACROLIMUS (Strides Arcolab Limited), TACROLIMUS (Watson Laboratories)
Formula
C44H69NO12. H2O
Exact mass
821.4925
Mol weight
822.0334
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Streptomyces tsukubaensis [TAX:83656]
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drugs (DMARDs)
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiallergic, Immunosuppressant, Calcineurin inhibitor
Comment
Macrolide
Complex Tacrolimus and FK506 binding protein (FKBP12/12.6) [HSA:2280 2281] [KO:K09568] inhibit calcineurin.
Target
  Pathway
T cell receptor signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Immunosuppressive agents
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AH Agents for dermatitis, excluding corticosteroids
     D11AH01 Tacrolimus
      D00107  Tacrolimus (USAN/INN)
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AD Calcineurin inhibitors
     L04AD02 Tacrolimus
      D00107  Tacrolimus (USAN/INN)
USP drug classification [BR:br08302]
 Dermatological Agents
  Tacrolimus
   D00107  Tacrolimus (USAN/INN)
 Immunological Agents
  Immune Suppressants
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00107  Tacrolimus (USAN/INN); Tacrolimus hydrate (JP17)
 2  Agents affecting individual organs
  26  Epidermides
   269  Miscellaneous
    2699  Others
     D00107  Tacrolimus (USAN/INN); Tacrolimus hydrate (JP17)
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00107  Tacrolimus (USAN/INN); Tacrolimus hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   calcineurin
    Tacrolimus
     D00107  Tacrolimus (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP3A
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
 CYP substrates
  CYP3A4
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
  CYP3A5
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
  CYP3A7
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
  CYP3A
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
 Transporter inhibitors
  ABCB1
   Tacrolimus
    D00107  Tacrolimus (USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00107  Tacrolimus hydrate
  D00107  Tacrolimus capsules
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D00107
Dermatological agents [br08370.html]
 Non-steroidal topical agent
  D00107
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00107
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00107
BRITE hierarchy
Other DBs
CAS: 
109581-93-3
PubChem: 
ChEBI: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        58
            1   O0  O    31.6167  -21.2567
            2   C2c C    22.3300  -12.4600
            3   C2b C    22.3300  -11.0600
            4   C1y C    21.1400  -10.2900
            5   C1x C    21.1400   -8.8900
            6   C1x C    19.8800   -8.1900
            7   C1y C    18.6900   -8.8900
            8   C1y C    18.6900  -10.2900
            9   C1x C    19.8800  -11.0600
            10  O2a O    17.5000  -11.0600
            11  O1a O    17.5000   -8.1900
            12  C1a C    16.3100  -10.2900
            13  C1c C    23.5900  -13.1600
            14  C1a C    21.1400  -13.1600
            15  C1c C    24.7800  -12.4600
            16  C1c C    25.9700  -13.1600
            17  C1b C    25.9700  -14.5600
            18  C5a C    27.3000  -15.1200
            19  C1c C    27.9300  -16.4500
            20  C2b C    27.2300  -17.7100
            21  C2c C    25.9700  -18.4100
            22  C1a C    24.7800  -17.7100
            23  C1b C    25.9700  -19.8100
            24  C1c C    24.7800  -20.5100
            25  C1a C    23.5900  -19.8100
            26  C1b C    25.4800  -21.7000
            27  C1c C    24.5000  -22.8200
            28  C1y C    23.1700  -22.4000
            29  C1y C    22.1200  -23.4500
            30  C1x C    20.7900  -23.1000
            31  C1y C    20.4400  -21.7000
            32  C1z C    21.4200  -20.7200
            33  O2x O    22.8200  -21.0700
            34  O2a O    22.5400  -24.7800
            35  O2a O    24.8500  -24.1500
            36  C1a C    26.1800  -24.5700
            37  C1a C    21.4900  -25.7600
            38  O1a O    22.6800  -20.0900
            39  C5a C    20.7200  -19.5300
            40  C5a C    21.4200  -18.2700
            41  N1y N    20.7200  -17.0800
            42  C1x C    19.3200  -17.0800
            43  C1y C    21.4200  -15.8900
            44  C1x C    20.7200  -14.6300
            45  C1x C    19.3200  -14.6300
            46  C1x C    18.6200  -15.8200
            47  O5a O    22.8900  -18.2700
            48  O5a O    19.3200  -19.5300
            49  C1a C    19.0400  -21.3500
            50  C7a C    22.8900  -15.8900
            51  O6a O    23.5900  -17.0800
            52  O7a O    23.5900  -14.6300
            53  C1a C    24.7800  -11.0600
            54  O1a O    27.1600  -12.4600
            55  O5a O    28.3500  -14.3500
            56  C1b C    29.3300  -16.4500
            57  C2b C    30.1000  -15.3300
            58  C2a C    31.4300  -15.2600
BOND        60
            1     2   3 2
            2     4   3 1 #Up
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     4   9 1
            9     8  10 1 #Up
            10    7  11 1 #Down
            11   10  12 1
            12    2  13 1
            13    2  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 2
            21   21  22 1
            22   21  23 1
            23   23  24 1
            24   24  25 1 #Up
            25   24  26 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1
            30   30  31 1
            31   31  32 1
            32   32  33 1
            33   33  28 1
            34   29  34 1 #Up
            35   27  35 1 #Down
            36   35  36 1
            37   34  37 1
            38   32  38 1 #Up
            39   32  39 1
            40   39  40 1
            41   42  41 1
            42   41  43 1
            43   43  44 1
            44   44  45 1
            45   45  46 1
            46   42  46 1
            47   40  41 1
            48   40  47 2
            49   39  48 2
            50   31  49 1 #Up
            51   43  50 1
            52   50  51 2
            53   50  52 1
            54   13  52 1 #Down
            55   15  53 1 #Down
            56   16  54 1 #Up
            57   18  55 2
            58   19  56 1 #Down
            59   56  57 1
            60   57  58 2

» Japanese version   » Back

DBGET integrated database retrieval system