| Entry |
|
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| Name |
Tacrolimus hydrate (JP16);
Tacrolimus (USAN/INN);
Prograf (TN);
Protopic (TN)
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| Product |
|
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| Generic |
TACROLIMUS (Accord Heathcare), TACROLIMUS (American Health Packaging), TACROLIMUS (Cardinal Health), TACROLIMUS (Dr. Reddy's Laboratories Limited), TACROLIMUS (Ingenus Pharmaceuticals), TACROLIMUS (KAISER FOUNDATION HOSPITALS), TACROLIMUS (Kremers Urban Pharmaceuticals), TACROLIMUS (Mylan Pharmaceuticals), HECORIA (Novartis Pharmaceuticals Corporation), TACROLIMUS (Sandoz), TACROLIMUS (Sandoz), TACROLIMUS (UDL Laboratories), TACROLIMUS (Watson Laboratories) |
|---|
| Formula |
C44H69NO12. H2O
|
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| Exact mass |
821.4925
|
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| Mol weight |
822.0334
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| Structure |
     |
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| Source |
Streptomyces tsukubaensis [TAX: 83656]
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| Activity |
|
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| Remark |
Therapeutic category: ATC code: |
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| Comment |
Macrolide
Complex Tacrolimus and FK506 binding protein (FKBP12/12.6) [HSA: 2280 2281] [KO: K09568] inhibit calcineurin.
|
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| Target |
|
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| Pathway |
hsa04660 T cell receptor signaling pathway | |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
|
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| Structure map |
| Immunosuppressive agents | | Antirheumatics - DMARDs and biological agents |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
2 Agents affecting individual organs
26 Epidermides
269 Miscellaneous
2699 Others
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
3 Agents affecting metabolism
39 Other agents affecting metabolism
399 Miscellaneous
3999 Others
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AH Agents for dermatitis, excluding corticosteroids
D11AH01 Tacrolimus
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 IMMUNOSUPPRESSANTS
L04A IMMUNOSUPPRESSANTS
L04AD Calcineurin inhibitors
L04AD02 Tacrolimus
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
USP drug classification [BR:br08302]
Dermatological Agents
Dermatological Calcineurin Inhibitor Immunosuppresants
Tacrolimus
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
Immunological Agents
Immune Suppressants
Non-TNF Blockers
Tacrolimus
D00107 Tacrolimus hydrate (JP16); Tacrolimus (USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases
calcineurin [HSA:5530 5532 5533 5534 5535 11261 63928] [KO:K04348 K06268]
Tacrolimus [ATC:D11AH01 L04AD02]
D00107 Tacrolimus (USAN/INN)
 |
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| Other DBs |
CAS: 109581-93-3 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 58
1 O0 O 31.6167 -21.2567
2 C2c C 22.3300 -12.4600
3 C2b C 22.3300 -11.0600
4 C1y C 21.1400 -10.2900
5 C1x C 21.1400 -8.8900
6 C1x C 19.8800 -8.1900
7 C1y C 18.6900 -8.8900
8 C1y C 18.6900 -10.2900
9 C1x C 19.8800 -11.0600
10 O2a O 17.5000 -11.0600
11 O1a O 17.5000 -8.1900
12 C1a C 16.3100 -10.2900
13 C1c C 23.5900 -13.1600
14 C1a C 21.1400 -13.1600
15 C1c C 24.7800 -12.4600
16 C1c C 25.9700 -13.1600
17 C1b C 25.9700 -14.5600
18 C5a C 27.3000 -15.1200
19 C1c C 27.9300 -16.4500
20 C2b C 27.2300 -17.7100
21 C2c C 25.9700 -18.4100
22 C1a C 24.7800 -17.7100
23 C1b C 25.9700 -19.8100
24 C1c C 24.7800 -20.5100
25 C1a C 23.5900 -19.8100
26 C1b C 25.4800 -21.7000
27 C1c C 24.5000 -22.8200
28 C1y C 23.1700 -22.4000
29 C1y C 22.1200 -23.4500
30 C1x C 20.7900 -23.1000
31 C1y C 20.4400 -21.7000
32 C1z C 21.4200 -20.7200
33 O2x O 22.8200 -21.0700
34 O2a O 22.5400 -24.7800
35 O2a O 24.8500 -24.1500
36 C1a C 26.1800 -24.5700
37 C1a C 21.4900 -25.7600
38 O1a O 22.6800 -20.0900
39 C5a C 20.7200 -19.5300
40 C5a C 21.4200 -18.2700
41 N1y N 20.7200 -17.0800
42 C1x C 19.3200 -17.0800
43 C1y C 21.4200 -15.8900
44 C1x C 20.7200 -14.6300
45 C1x C 19.3200 -14.6300
46 C1x C 18.6200 -15.8200
47 O5a O 22.8900 -18.2700
48 O5a O 19.3200 -19.5300
49 C1a C 19.0400 -21.3500
50 C7a C 22.8900 -15.8900
51 O6a O 23.5900 -17.0800
52 O7a O 23.5900 -14.6300
53 C1a C 24.7800 -11.0600
54 O1a O 27.1600 -12.4600
55 O5a O 28.3500 -14.3500
56 C1b C 29.3300 -16.4500
57 C2b C 30.1000 -15.3300
58 C2a C 31.4300 -15.2600
BOND 60
1 2 3 2
2 4 3 1 #Up
3 4 5 1
4 5 6 1
5 6 7 1
6 7 8 1
7 8 9 1
8 4 9 1
9 8 10 1 #Up
10 7 11 1 #Down
11 10 12 1
12 2 13 1
13 2 14 1
14 13 15 1
15 15 16 1
16 16 17 1
17 17 18 1
18 18 19 1
19 19 20 1
20 20 21 2
21 21 22 1
22 21 23 1
23 23 24 1
24 24 25 1 #Up
25 24 26 1
26 26 27 1
27 27 28 1
28 28 29 1
29 29 30 1
30 30 31 1
31 31 32 1
32 32 33 1
33 33 28 1
34 29 34 1 #Up
35 27 35 1 #Down
36 35 36 1
37 34 37 1
38 32 38 1 #Up
39 32 39 1
40 39 40 1
41 42 41 1
42 41 43 1
43 43 44 1
44 44 45 1
45 45 46 1
46 42 46 1
47 40 41 1
48 40 47 2
49 39 48 2
50 31 49 1 #Up
51 43 50 1
52 50 51 2
53 50 52 1
54 13 52 1 #Down
55 15 53 1 #Down
56 16 54 1 #Up
57 18 55 2
58 19 56 1 #Down
59 56 57 1
60 57 58 2
|
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