KEGG   DRUG: EphedrineHelp
Entry
D00124                      Drug                                   

Name
Ephedrine (USP);
Ephedrine (TN)
Formula
C10H15NO
Exact mass
165.1154
Mol weight
165.2322
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Source
Ephedra sinica [TAX:33152]
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Bronchodilator, Adrenergic receptor agonist
Comment
Phenethylamine derivative
Ephedra alkaloid
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137];
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140];
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D00124  Ephedrine (USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D00124  Ephedrine (USP)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D00124  Ephedrine (USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D00124  Ephedrine (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D00124  Ephedrine (USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Ephedrine
    D00124  Ephedrine (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ephedrine
    D00124  Ephedrine (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    alpha2-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    beta1-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    beta2-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    beta3-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived by amination reactions
   Phenylalanine derived alkaloids
    D00124  Ephedrine (USP)
BRITE hierarchy
Other DBs
CAS: 
299-42-3
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8x C    18.1508  -17.0380
            2   C8x C    18.1508  -18.4401
            3   C8x C    19.3680  -19.1412
            4   C8x C    20.5781  -18.4401
            5   C8y C    20.5781  -17.0380
            6   C8x C    19.3680  -16.3369
            7   C1c C    21.7836  -16.3369
            8   C1c C    22.9945  -17.0308
            9   N1b N    24.2054  -16.3298
            10  C1a C    25.4164  -17.0237
            11  O1a O    21.7791  -14.9348
            12  C1a C    22.9975  -18.4330
BOND        12
            1     6   1 1
            2     5   7 1
            3     1   2 2
            4     7   8 1
            5     2   3 1
            6     8   9 1
            7     3   4 2
            8     9  10 1
            9     4   5 1
            10    7  11 1 #Up
            11    5   6 2
            12    8  12 1 #Up

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