KEGG   DRUG: D00124Help
Entry
D00124                      Drug                                   

Name
Ephedrine (USP);
Ephedrine (TN)
Formula
C10H15NO
Exact mass
165.1154
Mol weight
165.2322
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Ephedra sinica [TAX:33152]
Activity
Bronchodilator [DS:H00079]
Remark
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D00124  Ephedrine (USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D00124  Ephedrine (USP)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D00124  Ephedrine (USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D00124  Ephedrine (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D00124  Ephedrine (USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Ephedrine
    D00124  Ephedrine (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ephedrine
    D00124  Ephedrine (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    alpha2-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    beta1-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    beta2-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
    beta3-adrenergic receptor
     Ephedrine
      D00124  Ephedrine (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived by amination reactions
   Phenylalanine derived alkaloids
    D00124  Ephedrine (USP)
BRITE hierarchy
Other DBs
CAS: 
299-42-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C8x C    18.1508  -17.0380
            2   C8x C    18.1508  -18.4401
            3   C8x C    19.3680  -19.1412
            4   C8x C    20.5781  -18.4401
            5   C8y C    20.5781  -17.0380
            6   C8x C    19.3680  -16.3369
            7   C1c C    21.7836  -16.3369
            8   C1c C    22.9945  -17.0308
            9   N1b N    24.2054  -16.3298
            10  C1a C    25.4164  -17.0237
            11  O1a O    21.7791  -14.9348
            12  C1a C    22.9975  -18.4330
BOND        12
            1     6   1 1
            2     5   7 1
            3     1   2 2
            4     7   8 1
            5     2   3 1
            6     8   9 1
            7     3   4 2
            8     9  10 1
            9     4   5 1
            10    7  11 1 #Up
            11    5   6 2
            12    8  12 1 #Up

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