KEGG   DRUG: D00135Help
Entry
D00135                      Drug                                   

Name
Capreomycin sulfate (JAN/USP);
Capastat sulfate (TN)
Product
Formula
C25H43N14O7R. 2H2SO4
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [tuberculostatic] [DS:H00342]
Remark
ATC code: 
Comment
Mixture of sulfate salt of Capreomycin IA and Capreomycin IB
Capreomycin IA (R = -OH)
Capreomycin IB (R = -H)
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980];
16S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AB Antibiotics
     J04AB30 Capreomycin
      D00135  Capreomycin sulfate (JAN/USP)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Capreomycin
    D00135  Capreomycin sulfate (JAN/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Others
    Peptides
     Capreomycin [ATC:J04AB30]
      D00135  Capreomycin sulfate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
1405-37-4
PubChem: 
DrugBank: 
NIKKAJI: 
KCF data Show

ATOM        57
            1   S4a S    12.7522  -15.7504
            2   O1d O    12.7451  -14.3513
            3   O1d O    12.7451  -17.1495
            4   O1d O    14.1514  -15.7504
            5   O1d O    11.3531  -15.7435
            6   C1y C    21.8642  -11.1112
            7   N1x N    23.0604  -10.4205
            8   C5x C    24.2568  -11.1112
            9   C1y C    25.4532  -10.4205
            10  N1x N    26.6495  -11.1112
            11  C5x C    27.8458  -10.4205
            12  C1y C    29.0422  -11.1112
            13  N1a N    30.2385  -10.4205
            14  C1b C    20.6678  -10.4205
            15  N1b N    19.4714  -11.1112
            16  C5x C    21.8642  -12.4925
            17  N1x N    23.0498  -13.1770
            18  C2y C    23.0500  -14.5645
            19  O5x O    20.6572  -13.1894
            20  O5x O    24.2568  -12.4926
            21  C1b C    25.4532   -9.0391
            22  O5x O    27.8458   -9.0392
            23  R   R    24.2482   -8.3433
            24  C1x C    29.0422  -12.4926
            25  N1x N    27.8459  -13.1833
            26  C5x C    27.8459  -14.5647
            27  C1y C    26.6595  -15.2497
            28  O5x O    29.0522  -15.2612
            29  N1x N    25.4848  -14.5714
            30  C5x C    24.3108  -15.2492
            31  O5x O    24.2589  -16.6369
            32  C1y C    26.6594  -16.9129
            33  N1x N    25.4822  -17.5926
            34  C1y C    25.4823  -18.9741
            35  N2x N    26.6787  -19.6647
            36  C2x C    27.8558  -18.9849
            37  C1x C    27.8557  -17.6035
            38  N1a N    24.3028  -19.6555
            39  C2b C    21.8674  -15.2682
            40  N1b N    20.6619  -14.5931
            41  C5a C    19.4634  -15.3065
            42  N1a N    18.2532  -14.6289
            43  O5a O    19.4820  -16.7105
            44  C5a C    18.2587  -10.4110
            45  C1b C    17.0467  -11.1108
            46  C1c C    15.8675  -10.4300
            47  C1b C    14.6721  -11.1204
            48  C1b C    13.4847  -10.4349
            49  O5a O    18.2589   -9.0300
            50  N1a N    15.8675   -9.0302
            51  C1b C    12.2935  -11.1229
            52  N1a N    11.1040  -10.4362
            53  S4a S    12.7522  -15.7504
            54  O1d O    12.7451  -14.3513
            55  O1d O    12.7451  -17.1495
            56  O1d O    14.1514  -15.7504
            57  O1d O    11.3531  -15.7435
BOND        56
            1     6   7 1
            2     7   8 1
            3     8   9 1
            4     9  10 1
            5    10  11 1
            6    11  12 1
            7    12  13 1 #Up
            8    14  15 1
            9     6  14 1 #Up
            10    6  16 1
            11   16  17 1
            12   17  18 1
            13   16  19 2
            14    8  20 2
            15    9  21 1 #Up
            16   11  22 2
            17   21  23 1
            18   12  24 1
            19   24  25 1
            20   25  26 1
            21   26  27 1
            22   26  28 2
            23   27  29 1
            24   29  30 1
            25   30  18 1
            26   30  31 2
            27   27  32 1
            28   32  33 1
            29   33  34 1
            30   34  35 1
            31   35  36 2
            32   36  37 1
            33   32  37 1
            34   34  38 1
            35   18  39 2
            36   39  40 1
            37   40  41 1
            38   41  42 1
            39   41  43 2
            40   15  44 1
            41   44  45 1
            42   45  46 1
            43   46  47 1
            44   47  48 1
            45   44  49 2
            46   46  50 1 #Up
            47   48  51 1
            48   51  52 1
            49    1   2 2
            50    1   3 2
            51    1   4 1
            52    1   5 1
            53   53  54 2
            54   53  55 2
            55   53  56 1
            56   53  57 1
BRACKET     1    10.2200  -17.6400   10.2200  -13.7900
            1    15.4000  -13.7900   15.4000  -17.6400
            1  2
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1   55  56  57  58  59

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