KEGG   DRUG: D00136Help
Entry
D00136                      Drug                                   

Name
Haloperidol (JP16/USP/INN);
Haldol (TN)
Product
  Generic
HALOPERIDOL (American Health Packaging), HALOPERIDOL (Cadila Healthcare Limited), HALOPERIDOL (Cardinal Health), HALOPERIDOL (Cardinal Health), HALOPERIDOL (Cardinal Health), HALOPERIDOL (Contract Pharmacy Services-PA), HALOPERIDOL (Dispensing Solutions), HALOPERIDOL (Major Pharmaceuticals), HALOPERIDOL (McKesson Contract Packaging), HALOPERIDOL (Mylan Institutional), HALOPERIDOL (Mylan Pharmaceuticals), HALOPERIDOL (NCS HealthCare of KY), HALOPERIDOL (NCS HealthCare of KY), HALOPERIDOL (Patriot Pharmaceuticals LLC), HALOPERIDOL (Pharmaceutical Associates), HALOPERIDOL (Physicians Total Care), HALOPERIDOL (Qualitest Pharmaceuticals), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (REMEDYREPACK), HALOPERIDOL (Rebel Distributors Corp), HALOPERIDOL (Sandoz), HALOPERIDOL (State of Florida DOH Central Pharmacy), HALOPERIDOL (State of Florida DOH Central Pharmacy), HALOPERIDOL (State of Florida DOH Central Pharmacy), HALOPERIDOL (Zydus Pharmaceuticals (USA))
Formula
C21H23ClFNO2
Exact mass
375.1401
Mol weight
375.8642
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidyskinetic [in Gilles de la Tourette's disease];
Antipsychotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Butyrophenone derivatives
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Antipsychotics
Butyrophenones
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD01 Haloperidol
      D00136  Haloperidol (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Haloperidol
    D00136  Haloperidol (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00136  Haloperidol (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Haloperidol
      D00136  Haloperidol (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Haloperidol
    D00136  Haloperidol (JP16/USP/INN)
  CYP2D6
   Haloperidol
    D00136  Haloperidol (JP16/USP/INN)
  CYP3A4
   Haloperidol
    D00136  Haloperidol (JP16/USP/INN)
  CYP3A5
   Haloperidol
    D00136  Haloperidol (JP16/USP/INN)
  CYP3A7
   Haloperidol
    D00136  Haloperidol (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00136  Haloperidol
  D00136  Haloperidol fine granules
  D00136  Haloperidol tablets
BRITE hierarchy
Other DBs
CAS: 
52-86-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C1b C    19.7303  -17.5616
            2   C1b C    20.9898  -16.8619
            3   C1b C    22.2494  -17.5616
            4   N1y N    23.4389  -16.8619
            5   C1x C    23.4389  -15.4624
            6   C1x C    24.6285  -17.5616
            7   C1x C    24.6285  -14.7626
            8   C1x C    25.8181  -16.8619
            9   C1z C    25.8181  -15.4624
            10  C8y C    27.0076  -14.7626
            11  C8x C    27.0076  -13.4331
            12  C8x C    28.2672  -15.4624
            13  C8x C    28.2672  -12.7334
            14  C8x C    29.4567  -14.7626
            15  C8y C    29.4567  -13.4331
            16  X   Cl   30.6463  -12.7334
            17  C5a C    18.5407  -16.8619
            18  C8y C    17.3512  -17.5616
            19  O5a O    18.5407  -15.3924
            20  C8x C    17.3512  -18.9611
            21  C8x C    16.0916  -19.6608
            22  C8y C    14.8321  -18.9611
            23  C8x C    14.8321  -17.5616
            24  C8x C    16.0916  -16.8619
            25  X   F    13.6425  -19.6608
            26  O1a O    27.0305  -16.1624
BOND        28
            1     9  10 1
            2    10  11 1
            3    10  12 2
            4    11  13 2
            5    12  14 1
            6    13  15 1
            7    15  16 1
            8     8   9 1
            9    14  15 2
            10    1  17 1
            11    1   2 1
            12   17  18 1
            13    2   3 1
            14   17  19 2
            15    3   4 1
            16    4   5 1
            17    4   6 1
            18    5   7 1
            19    6   8 1
            20   18  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  18 2
            26    7   9 1
            27   22  25 1
            28    9  26 1

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