KEGG   DRUG: D00140Help
Entry
D00140                      Drug                                   

Name
Erythromycin (JP16/USP/INN);
EM;
Akne-mycin (TN);
Eryc (TN);
Erygel (TN);
Pce (TN);
Staticin (TN);
T-stat (TN)
Product
  Generic
ERYTHROMYCIN (A-S Medication Solutions LLC), ERY-TAB (A-S Medication Solutions LLC), ERYTHROMYCIN (A-S Medication Solutions LLC), ERYTHROMYCIN (A-S Medication Solutions LLC), ERYTHROMYCIN (Aidarex Pharmaceuticals LLC), ERYTHROMYCIN (Akorn), ERYTHROMYCIN (Akorn), ERYTHROMYCIN (Arbor Pharmaceuticals), ERYTHROMYCIN (Arbor Pharmaceuticals), ERY-TAB (Arbor Pharmaceuticals), ERYTHROMYCIN (Bausch & Lomb Incorporated), ERYTHROMYCIN BASE FILMTAB (Cardinal Health), ERYTHROMYCIN (Cardinal Health), ERYTHROMYCIN (Dispensing Solutions), ERYTHROMYCIN (E. FOUGERA &), ERYTHROMYCIN (E. FOUGERA &), ERYTHROMYCIN (Fera Pharmaceuticals), ILOTYCIN (Fera Pharmaceuticals), ERYTHROMYCIN (H.J. Harkins Company), ERYTHROMYCIN (KAISER FOUNDATION HOSPITALS), ERY-TAB (KAISER FOUNDATION HOSPITALS), ERYTHROMYCIN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ERYTHROMYCIN BASE FILMTAB (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ERYTHROMYCIN (Lake Erie Medical DBA Quality Care Products LLC), ERYTHROMYCIN (Midlothian Laboratories), ERYTHROMYCIN (Morton Grove Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERYTHROMYCIN BASE (PD-Rx Pharmaceuticals), ERYTHROMYCIN BASE (PD-Rx Pharmaceuticals), ERYTHRA-DERM (Paddock Laboratories), ERYTHROMYCIN (Perrigo New York), ERY (Perrigo New York), ERYTHROMYCIN (Perrigo New York), ERYTHROMYCIN (Physicians Total Care), ERY-TAB (Physicians Total Care), ERYTHROMYCIN (Physicians Total Care), ERYTHROMYCIN (Physicians Total Care), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYGEL (Prestium Pharma), ERYTHROMYCIN BASE (REMEDYREPACK), ERYTHROMYCIN BASE (REMEDYREPACK), ERY-TAB (REMEDYREPACK), ERYTHROMYCIN (REMEDYREPACK), ERYTHROMYCIN BASE (REMEDYREPACK), ERYTHROMYCIN (REMEDYREPACK), ERY-TAB (REMEDYREPACK), ERYTHROMYCIN (Rebel Distributors Corp), ERY-TAB (Rebel Distributors Corp), ERYTHROMYCIN BASE FILMTAB (Rebel Distributors Corp), ERYTHROMYCIN (STAT RX USA LLC), ERY-TAB (STAT Rx USA LLC), ERY-TAB (STAT Rx USA LLC), ERYTHROMYCIN (Stat Rx USA), ERYTHROMYCIN (Stat Rx USA), ERYTHROMYCIN (VersaPharm Incorporated)
Formula
C37H67NO13
Exact mass
733.4612
Mol weight
733.9268
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
0 Pyk  1 Mtk  2 Mtn  3 Mte  4 Mtk  5 Mtk  6 Mtn
  Type
PK
Source
Saccharopolyspora erythraea [TAX:1836]
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Natural product
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243], SLCO1B1 [HSA:10599]
Drug interaction
Structure map
Macrolides and ketolides
Other map
Bile secretion
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D00140  Erythromycin (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D00140  Erythromycin (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D00140  Erythromycin (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Erythromycin [ATC:D10AF02 J01FA01 S01AA17]
      D00140  Erythromycin (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
114-07-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        51
            1   C1y C    29.5344  -13.7288
            2   C1z C    29.5344  -12.3594
            3   C1y C    28.3449  -14.4078
            4   O2a O    31.5246  -14.4484
            5   C1x C    28.3449  -11.6747
            6   O1a O    30.5672  -11.3672
            7   C1a C    30.8225  -12.7945
            8   C1y C    28.3449  -15.7772
            9   C1a C    27.3697  -13.3814
            10  C1y C    33.1096  -13.7303
            11  C1y C    28.3449  -10.2995
            12  O2a O    29.0876  -17.1408
            13  C1y C    27.1669  -16.4620
            14  C1y C    34.2830  -14.4247
            15  O2x O    33.1216  -12.3614
            16  C5x C    27.1669   -9.6205
            17  C1a C    29.5344   -9.6205
            18  C1y C    30.6105  -17.5606
            19  C7x C    25.9774  -15.7772
            20  C1a C    27.1669  -17.8312
            21  C1y C    35.4739  -13.7601
            22  O1a O    34.2739  -15.7986
            23  C1y C    34.3175  -11.6941
            24  C1y C    25.9774  -10.2995
            25  O5x O    27.1669   -8.2511
            26  C1x C    30.6105  -18.9243
            27  O2x O    31.8001  -16.8760
            28  O7x O    25.9774  -14.4078
            29  O6a O    24.9155  -16.7288
            30  C1x C    35.4884  -12.3963
            31  N1c N    36.6522  -14.4516
            32  C1a C    34.3373  -10.3274
            33  C1y C    25.9774  -11.6747
            34  C1a C    24.7937   -9.6205
            35  C1z C    31.8001  -19.6148
            36  C1y C    32.9779  -17.5606
            37  C1y C    24.7937  -13.7288
            38  C1z C    24.7937  -12.3594
            39  O1a O    27.1669  -12.3594
            40  C1y C    32.9779  -18.9243
            41  O2a O    31.8001  -20.9437
            42  C1a C    33.2507  -20.6013
            43  C1a C    34.1675  -16.8818
            44  C1b C    23.6099  -14.4078
            45  C1a C    23.5404  -12.9279
            46  O1a O    23.5404  -11.6690
            47  O1a O    34.1675  -19.6148
            48  C1a C    32.9026  -21.9069
            49  C1a C    23.5747  -15.5334
            50  C1a C    37.9042  -13.7409
            51  C1a C    36.7130  -15.8195
BOND        53
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1

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