KEGG   DRUG: D00141Help
Entry
D00141                      Drug                                   

Name
Indometacin (JP16/INN);
Indomethacin (USP);
Aconip (TN);
Indocin (TN)
Product
  Generic
INDOMETHACIN (A-S Medication Solutions LLC), INDOMETHACIN (Actavis), INDOMETHACIN (American Health Packaging), INDOMETHACIN (Amneal Pharmaceuticals), INDOMETHACIN ER (Apotheca), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Caraco Pharmaceutical Laboratories), INDOMETHACIN (Cardinal Health), INDOMETHACIN (Clinical Solutions Wholesale), INDOMETHACIN (Direct Rx), INDOMETHACIN (Dispensing Solutions), INDOMETHACIN (Eon Labs), INDOMETHACIN (G & W LABORATORIES), INDOMETHACIN (Glenmark Generics), INDOMETHACIN (Hetero Drugs Ltd.,), INDOCIN (Iroko Pharmaceuticals), INDOMETHACIN (KVK-Tech), INDOMETHACIN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), INDOMETHACIN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), INDOMETHACIN (Lake Erie Medical DBA Quality Care Products LLC), INDOMETHACIN (Lake Erie Medical DBA Quality Care Products LLC), INDOMETHACIN (MedVantx), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (Paddock Laboratories), INDOMETHACIN (Physicians Total Care), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (Rebel Distributors Corp), INDOMETHACIN (Rebel Distributors Corp), INDOMETHACIN (Rebel Distributors Corp), INDOMETHACIN (Rebel Distributors Corp), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (STAT RX USA LLC), INDOMETHACIN (Sandoz), INDOMETHACIN (Teva Pharmaceuticals USA), INDOMETHACIN (Unit Dose Services), INDOMETHACIN EXTENDED-RELEASE (Keltman Pharmaceuticals)
Formula
C19H16ClNO4
Exact mass
357.0768
Mol weight
357.7876
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-inflammatory
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
hsa04370  VEGF signaling pathway  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB03 Indometacin
      D00141  Indometacin (JP16/INN); Indomethacin (USP)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB01 Indometacin
      D00141  Indometacin (JP16/INN); Indomethacin (USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA23 Indometacin
      D00141  Indometacin (JP16/INN); Indomethacin (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC01 Indometacin
      D00141  Indometacin (JP16/INN); Indomethacin (USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1145  Indomethacins
     D00141  Indometacin (JP16/INN); Indomethacin (USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00141  Indometacin (JP16/INN); Indomethacin (USP)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00141  Indometacin (JP16/INN); Indomethacin (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00141  Indometacin (JP16/INN); Indomethacin (USP)
  -- Analgesic and anti-inflammatory remedies (patches)
   D00141  Indometacin (JP16/INN); Indomethacin (USP)
  -- Analgesic and anti-inflammatory remedies (embrocations)
   D00141  Indometacin (JP16/INN); Indomethacin (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Indometacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Indometacin
     D00141  Indometacin (JP16/INN); Indomethacin (USP)
   cyclooxygenase-2 (COX-2)
    Indometacin
     D00141  Indometacin (JP16/INN); Indomethacin (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Indometacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
 Inhbitors
  CYP2C19
   Indometacin
    D00141  Indometacin (JP16/INN); Indomethacin (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00141  Indometacin
  D00141  Indometacin capsules
  D00141  Indometacin suppositories
BRITE hierarchy
Other DBs
CAS: 
53-86-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    23.8648  -19.0768
            2   C8y C    23.8564  -20.5490
            3   C1a C    25.1409  -21.2966
            4   C6a C    26.4256  -19.0915
            5   C1b C    25.1494  -18.3439
            6   C8y C    21.5264  -20.4363
            7   C8y C    21.5264  -19.0827
            8   N4y N    22.7025  -21.1172
            9   C8x C    20.3428  -21.1031
            10  C8x C    20.3428  -18.3946
            11  C5a C    22.7118  -22.4351
            12  C8x C    19.1807  -20.4363
            13  C8y C    19.1807  -19.0827
            14  C8y C    21.9087  -22.9293
            15  O2a O    18.0197  -18.4158
            16  C8x C    20.7461  -22.2186
            17  C8x C    21.8611  -24.2805
            18  C1a C    16.8577  -19.0968
            19  C8x C    19.5535  -22.8588
            20  C8x C    20.6841  -24.9202
            21  C8y C    19.5286  -24.2071
            22  X   Cl   18.3219  -24.7917
            23  O6a O    27.7101  -18.3588
            24  O6a O    26.4256  -20.5638
            25  O5a O    23.9557  -23.1242
BOND        27
            1     2   3 1
            2     6   7 2
            3     6   8 1
            4     6   9 1
            5     7   1 1
            6     7  10 1
            7     8   2 1
            8     8  11 1
            9     9  12 2
            10   10  13 2
            11   11  14 1
            12   13  15 1
            13   14  16 2
            14   14  17 1
            15   15  18 1
            16   16  19 1
            17   17  20 2
            18   19  21 2
            19   21  22 1
            20   12  13 1
            21   20  21 1
            22    4   5 1
            23    4  23 1
            24    5   1 1
            25    4  24 2
            26    1   2 2
            27   11  25 2

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