KEGG   DRUG: TrimethoprimHelp
Entry
D00145                      Drug                                   

Name
Trimethoprim (JAN/USP/INN);
Proloprim (TN);
Trimpex (TN)
Product
  Generic
Formula
C14H18N4O3
Exact mass
290.1379
Mol weight
290.3177
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01581  Trimethoprim antibacterial
Cyp inhibitor
 DG01641  CYP2C8 inhibitor
Unclassified
 DG01931  Antifolate, antibacterial
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Folic acid biosynthesis inhibitor
Comment
Trimethoprims
Target
dihydrofolate reductase [KO:K13938]
  Pathway
One carbon pool by folate
Folate biosynthesis
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01E SULFONAMIDES AND TRIMETHOPRIM
    J01EA Trimethoprim and derivatives
     J01EA01 Trimethoprim
      D00145  Trimethoprim (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Trimethoprim
    D00145  Trimethoprim (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C8
   Trimethoprim
    D00145  Trimethoprim (JAN/USP/INN)
Antibacterials [br08350.html]
 D00145
BRITE hierarchy
Other DBs
CAS: 
738-70-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8y C    15.9128  -15.6038
            2   C1b C    17.1236  -16.2959
            3   C8x C    14.6954  -16.3150
            4   C8x C    15.9128  -14.1943
            5   C8y C    18.3218  -15.5974
            6   C8y C    13.4846  -15.6038
            7   C8y C    14.6954  -13.4961
            8   C8y C    19.5327  -16.3085
            9   C8x C    18.3218  -14.1880
            10  C8y C    13.4846  -14.1943
            11  O2a O    12.2737  -16.2959
            12  O2a O    14.6891  -12.1057
            13  N5x N    20.7563  -15.5974
            14  N1a N    19.5262  -17.6988
            15  N5x N    19.5327  -13.4896
            16  O2a O    12.2800  -13.5661
            17  C1a C    11.0757  -15.5909
            18  C1a C    15.8936  -11.4010
            19  C8y C    20.7563  -14.1880
            20  C1a C    12.2800  -12.1057
            21  N1a N    21.9609  -13.4833
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    8  14 1
            14    9  15 2
            15   10  16 1
            16   11  17 1
            17   12  18 1
            18   13  19 2
            19   16  20 1
            20   19  21 1
            21    7  10 2
            22   15  19 1

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