KEGG   DRUG: Protirelin
Entry
D00176                      Drug                                   
Name
Protirelin (JP18/USAN/INN);
Relefact TRH (TN)
Formula
C16H22N6O4
Exact mass
362.1703
Mol weight
362.3837
Structure
Simcomp
Sequence
Glp His Pro-NH2
  Type
Peptide
Remark
Same as: C03958
Therapeutic category: 7223
ATC code: V04CJ02
Chemical structure group: DG01171
Product (DG01171): D00176<JP> D02007<JP>
Efficacy
Diagnostic (pituitary function determination), Thyrotropin-releasing hormone receptor agonist
Comment
tripeptide
Prothyrotropin, Thyrotropin-releasing hormone
Target
TRHR [HSA:7201] [KO:K04282]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V04 DIAGNOSTIC AGENTS
   V04C OTHER DIAGNOSTIC AGENTS
    V04CJ Tests for thyreoidea function
     V04CJ02 Protirelin
      D00176  Protirelin (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   722  Various function testing reagents
    7223  Diagnostic reagents for endocrine function
     D00176  Protirelin (JP18/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Thyrotropin-releasing hormone
    TRHR
     D00176  Protirelin (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00176  Protirelin
Other DBs
CAS: 24305-27-9
PubChem: 7847244
ChEBI: 35940
LigandBox: D00176
NIKKAJI: J3.473H
KCF data

ATOM        26
            1   C1x C    19.3265  -18.8642
            2   C1y C    19.7627  -17.5319
            3   N1x N    18.6256  -16.7050
            4   C5x C    17.4887  -17.5319
            5   C1x C    17.9248  -18.8642
            6   C8y C    24.6097  -14.7657
            7   C8x C    26.0045  -14.7648
            8   N5x N    26.4347  -13.4379
            9   C8x C    25.3058  -12.6190
            10  N4x N    24.1778  -13.4394
            11  C1x C    27.6583  -15.5370
            12  C1x C    28.0946  -16.8691
            13  C1y C    26.9575  -17.6960
            14  N1y N    25.8205  -16.8691
            15  C1x C    26.2567  -15.5370
            16  C5a C    24.6073  -17.5686
            17  C1c C    23.3968  -16.8678
            18  N1b N    22.1863  -17.5686
            19  C5a C    20.9758  -16.8678
            20  O5a O    20.9758  -15.4661
            21  C1b C    23.3968  -15.4661
            22  C5a C    26.9575  -19.0977
            23  O5a O    25.7436  -19.7985
            24  N1a N    28.1714  -19.7986
            25  O5a O    24.6061  -18.9702
            26  O5x O    16.1550  -17.1007
BOND        28
            1    11  12 1
            2    12  13 1
            3    13  14 1
            4    14  15 1
            5    15  11 1
            6     4   5 1
            7    14  16 1
            8     6   7 2
            9    16  17 1
            10    7   8 1
            11   17  18 1
            12    8   9 2
            13   18  19 1
            14    9  10 1
            15   19  20 2
            16   10   6 1
            17   17  21 1 #Up
            18   21   6 1
            19    5   1 1
            20   13  22 1 #Up
            21   22  23 2
            22    1   2 1
            23   22  24 1
            24    2   3 1
            25   16  25 2
            26    2  19 1 #Down
            27    3   4 1
            28    4  26 2

» Japanese version   » Back

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (5)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (13)   

Download RDF
DBGET integrated database retrieval system