| Entry |
|
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| Name |
Alprostadil (JP16/USP/INN);
Befar (TN);
Prink (TN);
Prostin VR pediatric (TN)
|
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| Product |
|
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| Generic |
|
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| Formula |
C20H34O5
|
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| Exact mass |
354.2406
|
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| Mol weight |
354.481
|
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| Structure |
     |
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| Activity |
Vasodilator
|
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
prostaglandin E1 receptor agonist [HSA: 5731] [KO: K04258] |
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
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| Interaction |
|
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| Structure map |
| Prostaglandins | | Eicosanoid receptor agonists/antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D00180 Alprostadil (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EA Prostaglandins
C01EA01 Alprostadil
D00180 Alprostadil (JP16/USP/INN)
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE01 Alprostadil
D00180 Alprostadil (JP16/USP/INN)
USP drug classification [BR:br08302]
Hormonal Agents
Hormonal Agents, Stimulant / Replacement/ Modifying (Prostaglandins)
Prostaglandin Analogs
Alprostadil
D00180 Alprostadil (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostaglandin
prostaglandin E1 receptor [HSA:5731] [KO:K04258]
Alprostadil [ATC:C01EA01 G04BE01]
D00180 Alprostadil (JP16/USP/INN)
 |
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| Other DBs |
CAS: 745-65-3 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 25
1 C1y C 23.5830 -17.4951
2 C1y C 23.5770 -18.9049
3 C5x C 22.2430 -17.0640
4 C1b C 24.7947 -16.7901
5 C1y C 22.2604 -19.3360
6 C2b C 24.7947 -19.5983
7 C1x C 21.4215 -18.2057
8 O5x O 21.8061 -15.7356
9 C1b C 26.0066 -17.4951
10 O1a O 21.8409 -20.6703
11 C2b C 26.0066 -18.9049
12 C1b C 27.2243 -16.7901
13 C1c C 27.2243 -19.5983
14 C1b C 28.4301 -17.4951
15 C1b C 28.4360 -18.9049
16 O1a O 27.2243 -21.0023
17 C1b C 29.6477 -16.7901
18 C1b C 29.6477 -19.5983
19 C1b C 30.8654 -17.4951
20 C1b C 30.8654 -18.9049
21 C6a C 32.0773 -16.7901
22 C1b C 32.0773 -19.5983
23 O6a O 33.2890 -17.5009
24 O6a O 32.0306 -15.4268
25 C1a C 33.2950 -18.9049
BOND 25
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1 #Down
10 6 11 2
11 9 12 1
12 11 13 1
13 12 14 1
14 13 15 1
15 13 16 1 #Down
16 14 17 1
17 15 18 1
18 17 19 1
19 18 20 1
20 19 21 1
21 20 22 1
22 21 23 1
23 21 24 2
24 22 25 1
25 5 7 1
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