KEGG   DRUG: Nalidixic acidHelp
Entry
D00183                      Drug                                   

Name
Nalidixic acid (JP17/USP/INN);
NA;
NegGram (TN)
Formula
C12H12N2O3
Exact mass
232.0848
Mol weight
232.2353
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antibacterial
 DG01550  Quinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Quinolones
Target
DNA gyrase [KO:K02469 K02470];
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MB Other quinolones
     J01MB02 Nalidixic acid
      D00183  Nalidixic acid (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00183  Nalidixic acid (JP17/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Other quinolones
     Nalidixic acid
      D00183  Nalidixic acid (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00183  Nalidixic acid
Antibacterials [br08350.html]
 D00183
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00183
BRITE hierarchy
Other DBs
CAS: 
389-08-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    24.4685  -17.3910
            2   C8y C    24.4685  -15.9905
            3   N4y N    25.6963  -18.1008
            4   N5x N    23.2472  -18.1071
            5   C8y C    25.6836  -15.2743
            6   C8x C    23.2472  -15.2936
            7   C8x C    26.8773  -17.3975
            8   C1b C    25.6899  -19.4883
            9   C8y C    22.0386  -17.3910
            10  C8y C    26.9113  -15.9776
            11  O5x O    25.6770  -13.8803
            12  C8x C    22.0386  -15.9905
            13  C1a C    24.4878  -20.1854
            14  C1a C    20.8301  -18.0816
            15  C6a C    28.1134  -15.2807
            16  O6a O    29.3221  -15.9713
            17  O6a O    28.1706  -13.8868
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   15  16 1
            16   15  17 2
            17    7  10 2
            18    9  12 1

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