KEGG   DRUG: D00196Help
Entry
D00196                      Drug                                   

Name
Physostigmine (USP);
Eserine (TN)
Formula
C15H21N3O2
Exact mass
275.1634
Mol weight
275.3461
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Physostigma venenosum [TAX:271807]
Activity
Cholinergic [ophthalmic]
Remark
Same as: 
ATC code: 
Comment
Reversible cholinesterase inhibitor
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB05 Physostigmine
      D00196  Physostigmine (USP)
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB19 Physostigmine
      D00196  Physostigmine (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
    Physostigmine [ATC:S01EB05 V03AB19]
     D00196  Physostigmine (USP)
BRITE hierarchy
Other DBs
CAS: 
57-47-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1z C    26.2112  -14.1214
            2   C8y C    24.9526  -14.5409
            3   C1y C    27.0503  -15.2402
            4   C1x C    27.0503  -12.9326
            5   C1a C    25.3721  -13.0026
            6   C8y C    24.9526  -15.9395
            7   C8x C    23.6939  -13.8417
            8   N1y N    26.2112  -16.3591
            9   N1y N    28.3789  -14.8206
            10  C1x C    28.3789  -13.3522
            11  C8x C    23.6939  -16.6388
            12  C8y C    22.4353  -14.5409
            13  C1a C    26.6308  -17.6877
            14  C8x C    22.4353  -15.9395
            15  O7a O    21.2465  -13.8417
            16  C7a C    20.0578  -14.5409
            17  N1b N    18.8690  -13.8417
            18  O6a O    20.0578  -15.9395
            19  C1a C    17.6103  -14.5409
            20  C1a C    29.4977  -15.5899
BOND        22
            1    16  17 1
            2    16  18 2
            3    17  19 1
            4     6   8 1
            5     9  10 1
            6    12  14 1
            7     1   2 1
            8     1   3 1
            9     1   4 1
            10    1   5 1 #Up
            11    2   6 2
            12    2   7 1
            13    3   8 1
            14    3   9 1
            15    4  10 1
            16    6  11 1
            17    7  12 2
            18    8  13 1
            19   11  14 2
            20   12  15 1
            21   15  16 1
            22    9  20 1

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