KEGG   DRUG: D00197Help
Entry
D00197                      Drug                                   

Name
Reserpine (JP16/USP/INN);
Apoplon (TN);
Serpalan (TN)
Product
Formula
C33H40N2O9
Exact mass
608.2734
Mol weight
608.6787
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Rauvolfia serpentina [TAX:4060]
Activity
Antihypertensive
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
Vesicular monoamine transporter (VMAT) inhibitor [HSA:6570 6571] [KO:K08155]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Transporter inhibition: ABCC2 [HSA:1244]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AA Rauwolfia alkaloids
     C02AA02 Reserpine
      D00197  Reserpine (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00197  Reserpine (JP16/USP/INN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2143  Rauwolfias
     D00197  Reserpine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Major facilitator superfamily
   Vesicular monoamine transporter
    Reserpine
     D00197  Reserpine (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00197  Reserpine
  D00197  0.1% Reserpine powder
  D00197  Reserpine tablets
  D00197  Reserpine injection
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Indole alkaloids
    D00197  Reserpine (JP15/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
50-55-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        44
            1   C8y C    14.4712  -16.7139
            2   C1y C    15.6688  -15.9949
            3   N1y N    15.6450  -14.5981
            4   C1x C    14.4234  -13.9204
            5   C1x C    13.2257  -14.6395
            6   C8y C    13.2496  -16.0363
            7   C1x C    16.8904  -16.6725
            8   C1y C    18.0881  -15.9534
            9   C1y C    18.0642  -14.5567
            10  C1x C    16.8426  -13.8791
            11  C1y C    19.3097  -16.6312
            12  C1y C    20.5073  -15.9121
            13  C1y C    20.4834  -14.5153
            14  C1x C    19.2619  -13.8377
            15  C8y C    12.1078  -17.0605
            16  C8y C    12.8175  -18.2549
            17  N4x N    14.2041  -18.0851
            18  C8x C    10.7110  -17.0780
            19  C8x C    10.0277  -18.2965
            20  C8y C    10.7374  -19.4908
            21  C8x C    12.1342  -19.4733
            22  O2a O    10.0560  -20.7064
            23  C1a C     8.6196  -20.7249
            24  C7a C    19.3337  -18.0495
            25  O7a O    21.6809  -13.7964
            26  O2a O    21.7479  -16.6001
            27  O6a O    18.1454  -18.7627
            28  O7a O    20.5478  -18.7233
            29  C1a C    22.9456  -15.8811
            30  C7a C    21.7268  -12.3802
            31  C8y C    22.8463  -11.6663
            32  O6a O    20.4439  -11.7073
            33  C8x C    24.0803  -12.3510
            34  C8y C    25.2781  -11.6321
            35  C8y C    25.2543  -10.2354
            36  C8y C    24.0202   -9.5506
            37  C8x C    22.8225  -10.2695
            38  O2a O    26.4520   -9.5164
            39  C1a C    25.1942   -7.4348
            40  O2a O    23.9964   -8.1538
            41  O2a O    26.4826  -12.3004
            42  C1a C    27.6825  -11.5800
            43  C1a C    21.7867  -17.9802
            44  C1a C    27.6838  -10.1999
BOND        49
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     2   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    3  10 1
            12    8  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16    9  14 1
            17    6  15 1
            18   15  16 1
            19   16  17 1
            20    1  17 1
            21   15  18 2
            22   18  19 1
            23   19  20 2
            24   20  21 1
            25   16  21 2
            26   20  22 1
            27   22  23 1
            28   11  24 1 #Up
            29   13  25 1 #Up
            30   12  26 1 #Down
            31   24  27 2
            32   24  28 1
            33   26  29 1
            34   25  30 1
            35   30  31 1
            36   30  32 2
            37   31  33 2
            38   33  34 1
            39   34  35 2
            40   35  36 1
            41   36  37 2
            42   31  37 1
            43   35  38 1
            44   39  40 1
            45   36  40 1
            46   34  41 1
            47   41  42 1
            48   28  43 1
            49   38  44 1

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