KEGG   DRUG: D00199Help
Entry
D00199                      Drug                                   

Name
Ajmaline (JP16);
Ajimalin (TN)
Formula
C20H26N2O2
Exact mass
326.1994
Mol weight
326.4326
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Rauvolfia serpentina [TAX:4060]
Activity
Antiarrhythmic
Remark
Same as: 
ATC code: 
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA05 Ajmaline
      D00199  Ajmaline (JP16)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Ajmaline [ATC:C01BA05]
      D00199  Ajmaline (JP16)
BRITE hierarchy
Other DBs
CAS: 
4360-12-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8x C    20.0200  -16.5900
            2   C8x C    20.0200  -17.9900
            3   C8x C    21.2324  -18.6900
            4   C8y C    22.4449  -17.9900
            5   C8y C    22.4449  -16.5900
            6   C8x C    21.2324  -15.8900
            7   N1y N    23.7764  -18.4226
            8   C1y C    24.5993  -17.2900
            9   C1z C    23.7764  -16.1574
            10  C1y C    25.9916  -17.1437
            11  N1y N    26.5610  -15.8647
            12  C1y C    25.7381  -14.7321
            13  C1x C    24.3458  -14.8784
            14  C1x C    27.2706  -17.7131
            15  C1y C    27.8400  -16.4341
            16  C1y C    29.1794  -16.2051
            17  C1y C    27.9005  -15.6357
            18  C1b C    30.5794  -16.2051
            19  C1y C    26.5329  -12.8581
            20  O1a O    29.1532  -14.9290
            21  C1y C    23.8464  -12.8674
            22  C1a C    23.7764  -19.8226
            23  O1a O    22.8030  -11.8971
            24  C1a C    31.2973  -17.4482
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15    9  13 1
            16   10  14 1
            17   14  15 1
            18   15  16 1
            19   16  17 1
            20   11  17 1
            21   16  18 1 #Up
            22   12  19 1 #Up
            23   15  19 1 #Up
            24   17  20 1 #Down
            25    9  21 1 #Up
            26   21  19 1
            27    7  22 1
            28   21  23 1 #Down
            29   18  24 1

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