KEGG   DRUG: D00201Help
Entry
D00201                      Drug                                   

Name
Tetracycline (JAN/USP/INN);
TC;
Sumycin (TN)
Formula
C22H24N2O8
Exact mass
444.1533
Mol weight
444.4346
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-amebic;
Antibacterial;
Antirickettsial
Remark
Comment
Synthetic product
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB13 Tetracycline
      D00201  Tetracycline (JAN/USP/INN)
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AA Tetracycline and derivatives
     D06AA04 Tetracycline
      D00201  Tetracycline (JAN/USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA07 Tetracycline
      D00201  Tetracycline (JAN/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA09 Tetracycline
      D00201  Tetracycline (JAN/USP/INN)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA08 Tetracycline
      D00201  Tetracycline (JAN/USP/INN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA02 Tetracycline
      D00201  Tetracycline (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Tetracycline
    D00201  Tetracycline (JAN/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor [KO:K01977]
    Tetracyclines
     Tetracycline [ATC:A01AB13 D06AA04 J01AA07 S01AA09 S02AA08 S03AA02]
      D00201  Tetracycline (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
60-54-8
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C1y C    26.1736  -17.5845
            2   C1z C    26.1561  -18.9842
            3   C1x C    24.9730  -16.8757
            4   C1y C    27.3977  -16.9051
            5   C2y C    24.9438  -19.6696
            6   C5x C    27.3568  -19.6988
            7   O1a O    26.1385  -20.3782
            8   C1y C    23.7548  -17.5611
            9   C2y C    28.5925  -17.6197
            10  N1c N    27.4152  -15.5052
            11  C2y C    23.7431  -18.9608
            12  O1a O    24.9378  -21.0751
            13  C2y C    28.5750  -19.0194
            14  O5x O    27.4034  -21.0985
            15  C1z C    22.5424  -16.8582
            16  O1a O    29.8166  -16.9403
            17  C1a C    28.6393  -14.8201
            18  C1a C    26.2146  -14.7849
            19  C5x C    22.5307  -19.6579
            20  C5a C    29.7756  -19.7340
            21  C8y C    21.3301  -17.5551
            22  C1a C    22.5482  -15.4585
            23  C8y C    21.3241  -18.9550
            24  O5x O    22.5307  -21.0635
            25  N1a N    30.9997  -19.0546
            26  O5a O    29.7581  -21.1396
            27  C8x C    20.1177  -16.8523
            28  C8y C    20.1177  -19.6579
            29  C8x C    18.8995  -17.5551
            30  C8x C    18.8995  -18.9550
            31  O1a O    20.1234  -21.0576
            32  O1a O    21.3300  -16.1582
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     4   9 1
            9     4  10 1 #Down
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16   10  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   15  21 1
            21   15  22 1 #Down
            22   19  23 1
            23   19  24 2
            24   20  25 1
            25   20  26 2
            26   21  27 2
            27   23  28 2
            28   27  29 1
            29   28  30 1
            30   28  31 1
            31    8  11 1
            32    9  13 2
            33   21  23 1
            34   29  30 2
            35   15  32 1 #Up

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