KEGG   DRUG: Amphotericin BHelp
Entry
D00203                      Drug                                   

Name
Amphotericin B (JP17/USP/INN);
AMPH-B;
Ambisome (TN);
Amphotec (TN);
Fungizone (TN)
Product
  Generic
Formula
C47H73NO17
Exact mass
923.4879
Mol weight
924.079
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
0 Mak  1 Mtk  2 Mtd  3 Mad  4 Mad  5 Mad  6 Mad  7 Mad  8 Mad
9 Mak  10 Mak  11 Mtk  12 Man  13 Mak  14 Mak  15 Mae  16 Mak
17 Mak  18 Man
  Type
PK
Source
Streptomyces nodosus [TAX:40318]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antifungal, Antibiotic
Comment
Natural product
Polyenes
Amphotericin B binds to ergosterol, and configures a transmembrane channel which disrupt fungal cell.
Interaction
Drug interaction
Structure map
Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB04 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA07 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA03 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AA Antibiotics
     J02AA01 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6173  Amphotericin B
     D00203  Amphotericin B (JP17/USP/INN)
Antiinfectives [BR:br08307]
 Antifungals
  Cell membrane function inhibitor
   Polyene macrolides
    Amphotericin B
     D00203  Amphotericin B (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00203  Amphotericin B
  D00203  Amphotericin B tablets
  D00203  Amphotericin B syrup
  D00203  Amphotericin B for injection
Antifungals [br08352.html]
 D00203
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00203
BRITE hierarchy
Other DBs
CAS: 
1397-89-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        65
            1   C1y C    30.5612  -15.1927
            2   C1y C    31.7786  -14.4858
            3   O2x O    29.3393  -14.4916
            4   C1b C    30.5612  -16.5890
            5   C1y C    31.7786  -13.0895
            6   C6a C    32.9945  -15.1869
            7   C1z C    29.3393  -13.0895
            8   C1c C    29.3510  -17.2901
            9   C1x C    30.5612  -12.3884
            10  O1a O    32.9886  -12.3826
            11  O6a O    32.9945  -16.5890
            12  O6a O    34.2047  -14.4858
            13  C1b C    28.1349  -12.3943
            14  O2a O    29.3568  -18.6922
            15  C2b C    28.1466  -16.6007
            16  C1c C    26.9246  -13.0952
            17  C1y C    28.1466  -19.3992
            18  C2b C    26.9363  -17.2959
            19  C1b C    25.7075  -12.4001
            20  O1a O    26.9246  -14.4975
            21  C1y C    28.1525  -20.8083
            22  O2x O    26.9363  -18.6982
            23  C2b C    25.7261  -16.6136
            24  C1c C    24.4973  -13.1012
            25  C1y C    26.9423  -21.5096
            26  O1a O    29.3698  -21.4965
            27  C1y C    25.7261  -19.3992
            28  C2b C    24.5090  -17.3147
            29  C1c C    23.2872  -12.4060
            30  O1a O    24.5032  -14.5033
            31  C1y C    25.7261  -20.8083
            32  N1a N    26.9423  -22.9115
            33  C1a C    24.5032  -18.7109
            34  C2b C    23.2988  -16.6194
            35  C1b C    22.0828  -13.1140
            36  O1a O    24.5090  -21.5153
            37  C2b C    22.0945  -17.3206
            38  C1b C    20.8654  -12.4187
            39  C2b C    20.8843  -16.6253
            40  C1c C    19.6552  -13.1200
            41  C2b C    19.6669  -17.3264
            42  C1b C    18.4450  -12.4247
            43  O1a O    19.6552  -14.5219
            44  C2b C    18.4567  -16.6311
            45  C1c C    17.2348  -13.1257
            46  C2b C    17.2465  -17.3323
            47  C1b C    16.0234  -12.4304
            48  O1a O    17.2407  -14.5279
            49  C2b C    16.0422  -16.6369
            50  C7a C    14.8132  -13.1317
            51  C2b C    14.8190  -17.3381
            52  O7a O    13.6030  -12.4364
            53  O6a O    14.8132  -14.5336
            54  C2b C    13.6089  -16.6428
            55  C1c C    12.3927  -13.1374
            56  C2b C    12.3986  -17.3440
            57  C1c C    12.3927  -14.5396
            58  C1a C    11.1755  -12.4364
            59  C1c C    11.1755  -16.6428
            60  C1c C    11.1755  -15.2408
            61  C1a C    13.4689  -15.3808
            62  C1a C     9.9736  -17.3440
            63  O1a O     9.9736  -14.5396
            64  O1a O    23.2799  -10.9903
            65  O1a O    29.3393  -11.5495
BOND        67
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 1 #Down
            10    6  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1 #Up
            14    8  15 1
            15   13  16 1
            16   14  17 1
            17   15  18 2
            18   16  19 1
            19   16  20 1 #Up
            20   17  21 1
            21   17  22 1 #Up
            22   18  23 1
            23   19  24 1
            24   21  25 1
            25   21  26 1 #Up
            26   22  27 1
            27   23  28 2
            28   24  29 1
            29   24  30 1 #Up
            30   25  31 1
            31   25  32 1 #Up
            32   27  33 1 #Up
            33   28  34 1
            34   29  35 1
            35   31  36 1 #Down
            36   34  37 2
            37   35  38 1
            38   37  39 1
            39   38  40 1
            40   39  41 2
            41   40  42 1
            42   40  43 1 #Up
            43   41  44 1
            44   42  45 1
            45   44  46 2
            46   45  47 1
            47   45  48 1 #Up
            48   46  49 1
            49   47  50 1
            50   49  51 2
            51   50  52 1
            52   50  53 2
            53   51  54 1
            54   52  55 1
            55   54  56 2
            56   55  57 1
            57   55  58 1 #Down
            58   56  59 1
            59   57  60 1
            60   57  61 1 #Down
            61   59  62 1 #Down
            62   60  63 1 #Up
            63    7   9 1
            64   27  31 1
            65   59  60 1
            66   29  64 1 #Up
            67    7  65 1 #Up

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