KEGG   DRUG: D00205Help
Entry
D00205                      Drug                                   

Name
Oxytetracycline (JAN/USP/INN);
Oxytetracycline dihydrate;
OTC;
Terramycin (TN)
Formula
C22H24N2O9. 2H2O
Exact mass
496.1693
Mol weight
496.4645
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Streptomyces rimosus [TAX:1927]
Activity
Antibacterial
Remark
Comment
Natural product
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AA Tetracycline and derivatives
     D06AA03 Oxytetracycline
      D00205  Oxytetracycline (JAN/USP/INN)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA07 Oxytetracycline
      D00205  Oxytetracycline (JAN/USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA06 Oxytetracycline
      D00205  Oxytetracycline (JAN/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA04 Oxytetracycline
      D00205  Oxytetracycline (JAN/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 2
  Inorganic and organic chemicals
   Oxytetracycline
    D00205  Oxytetracycline (JAN/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Oxytetracycline
      D00205  Oxytetracycline (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
6153-64-6
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        35
            1   C1y C    23.5228  -17.1261
            2   C1z C    23.4995  -18.5006
            3   C1y C    22.3405  -16.4272
            4   C1y C    24.7225  -16.4505
            5   C2y C    22.3112  -19.1762
            6   C5x C    24.6818  -19.2054
            7   O1a O    23.4878  -19.8693
            8   C1y C    21.1349  -17.1028
            9   O1a O    22.3288  -14.7610
            10  C2y C    25.8990  -17.1553
            11  N1c N    24.7400  -15.0760
            12  C2y C    21.1232  -18.4773
            13  O1a O    22.2996  -20.5566
            14  C2y C    25.8814  -18.5355
            15  O5x O    24.7284  -20.5799
            16  C1z C    19.9467  -16.4038
            17  O1a O    27.1104  -16.4854
            18  C1a C    25.9456  -14.4004
            19  C1a C    24.6817  -13.4103
            20  C5x C    19.9350  -19.1645
            21  C5a C    27.0696  -19.2403
            22  C8y C    18.7470  -17.0911
            23  C1a C    19.9526  -14.6095
            24  C8y C    18.7411  -18.4715
            25  O5x O    19.9293  -20.5449
            26  N1a N    28.2693  -18.5705
            27  O5a O    27.1163  -20.6206
            28  C8x C    17.5530  -16.4038
            29  C8y C    17.5530  -19.1588
            30  C8x C    16.3591  -17.0911
            31  C8x C    16.3591  -18.4715
            32  O1a O    17.5588  -20.5390
            33  O1a O    18.7342  -15.7038
            34  O0  O    32.6282  -17.4422
            35  O0  O    32.6282  -17.4422
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    4  11 1 #Down
            11    5  12 2
            12    5  13 1
            13    6  14 1
            14    6  15 2
            15    8  16 1
            16   10  17 1
            17   11  18 1
            18   11  19 1
            19   12  20 1
            20   14  21 1
            21   16  22 1
            22   16  23 1 #Down
            23   20  24 1
            24   20  25 2
            25   21  26 1
            26   21  27 2
            27   22  28 2
            28   24  29 2
            29   28  30 1
            30   29  31 1
            31   29  32 1
            32    8  12 1
            33   10  14 2
            34   22  24 1
            35   30  31 2
            36   16  33 1 #Up
BRACKET     1    30.9400  -18.4800   30.9400  -16.4500
            1    33.3900  -16.4500   33.3900  -18.4800
            1  2
 ORIGINAL  1   36
 REPEAT    1   37

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