KEGG   DRUG: D00210Help
Entry
D00210                      Drug                                   

Name
Norfloxacin (JP16/USP/INN);
NFLX;
Noroxin (TN)
Product
Formula
C16H18FN3O3
Exact mass
319.1332
Mol weight
319.3308
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [DS:H00111 H00112 H00312 H00328]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP1A2 [HSA:1544]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA06 Norfloxacin
      D00210  Norfloxacin (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE02 Norfloxacin
      D00210  Norfloxacin (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00210  Norfloxacin (JP16/USP/INN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00210  Norfloxacin (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Norfloxacin
      D00210  Norfloxacin (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
  CYP3A4
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
 Inhbitors
  CYP1A2
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
  CYP3A4
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
  CYP3A5
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
  CYP3A7
   Norfloxacin
    D00210  Norfloxacin (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00210  Norfloxacin
BRITE hierarchy
Other DBs
CAS: 
70458-96-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    22.6983  -16.5436
            2   C8y C    22.6983  -15.1538
            3   N4y N    23.9247  -17.2386
            4   C8x C    21.4721  -17.2386
            5   C8y C    23.9247  -14.4530
            6   C8x C    21.4721  -14.4530
            7   C8x C    25.1509  -16.5436
            8   C1b C    23.9188  -18.6458
            9   C8y C    20.2516  -16.5436
            10  C8y C    25.1509  -15.1538
            11  O5x O    23.9188  -13.0399
            12  C8y C    20.2516  -15.1538
            13  C1a C    22.7042  -19.3349
            14  N1y N    19.0428  -17.2210
            15  C6a C    26.3654  -14.4414
            16  X   F    19.0428  -14.4707
            17  C1x C    17.8398  -16.5202
            18  C1x C    19.0428  -18.6050
            19  O6a O    27.5859  -15.1421
            20  O6a O    26.3597  -13.0283
            21  C1x C    16.6370  -17.2210
            22  C1x C    17.8457  -19.2998
            23  N1x N    16.6370  -18.6108
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1

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