KEGG   DRUG: D00214Help
Entry
D00214                      Drug                                   

Name
Actinomycin D (JP16);
Dactinomycin (USP);
Cosmegen (TN)
Product
Formula
C62H86N12O16
Exact mass
1254.6285
Mol weight
1255.417
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
0 4MHA  1 Thr  2 D-Val  3 Pro  4 Sar  5 Val
(Cyclization: 1-5, Dimer)
  Type
NRP
Source
Streptomyces parvullus [TAX:146923]
Activity
Antineoplastic [DS:H00028 H00035]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
natural product
Target
DNA (guanine)
Interaction
Drug interaction
Structure map
Antineoplastics - agents from natural products
Immunosuppressive agents
Other map
Bile secretion
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4233  Actinomycin D
     D00214  Actinomycin D (JP16); Dactinomycin (USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DA Actinomycines
     L01DA01 Dactinomycin
      D00214  Actinomycin D (JP16); Dactinomycin (USP)
Antineoplastics [BR:br08308]
 Natural products
  Antibiotics
   Dactinomycin [ATC:L01DA01]
    D00214  Actinomycin D (JP16); Dactinomycin (USP)
BRITE hierarchy
Other DBs
CAS: 
50-76-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        90
            1   C8y C    25.6418  -18.7249
            2   C8y C    25.6541  -17.4511
            3   N5x N    24.5349  -19.3619
            4   C8y C    26.7301  -19.3682
            5   O2x O    24.5473  -16.8017
            6   C8y C    26.7612  -16.8265
            7   C8y C    23.4279  -18.7188
            8   C8y C    27.8433  -18.7373
            9   C5a C    26.7240  -20.6481
            10  C8y C    23.4403  -17.4324
            11  C8y C    27.8619  -17.4696
            12  C1a C    26.7673  -15.5587
            13  C8y C    22.3395  -19.3558
            14  N1a N    28.9440  -19.3927
            15  N1b N    27.8248  -21.2974
            16  O5a O    25.6109  -21.2727
            17  C8y C    22.3395  -16.7956
            18  O5x O    28.9625  -16.8388
            19  C8x C    21.2326  -18.7188
            20  C5a C    22.3395  -20.6357
            21  C1y C    27.8124  -22.5714
            22  C8x C    21.2326  -17.4324
            23  C1a C    22.3395  -15.5216
            24  N1b N    21.2326  -21.2727
            25  O5a O    23.4403  -21.2666
            26  C5x C    26.6993  -23.2022
            27  C1y C    28.9132  -23.2206
            28  C1y C    21.2326  -22.5528
            29  N1x N    26.6540  -28.2854
            30  O5x O    25.6046  -22.5528
            31  O7x O    30.0263  -22.5899
            32  C1a C    28.9069  -24.4946
            33  C5x C    22.3395  -23.1835
            34  C1y C    20.1258  -23.1898
            35  C1y C    28.3999  -28.9841
            36  C7x C    31.1208  -23.2393
            37  N1x N    22.3334  -28.2235
            38  O5x O    23.4465  -22.5467
            39  O7x O    19.0311  -22.5591
            40  C1a C    20.1258  -24.4699
            41  C5x C    30.3416  -28.2667
            42  C1c C    28.3999  -30.2209
            43  C1y C    32.2339  -22.6147
            44  O6a O    31.1784  -24.5194
            45  C1y C    21.0286  -28.9285
            46  C7x C    17.9180  -23.1959
            47  N1y N    32.2524  -29.1139
            48  O5x O    30.3416  -26.9867
            49  C1a C    27.2868  -30.8579
            50  C1a C    29.5005  -30.8579
            51  N1y N    33.3347  -23.2578
            52  C1c C    32.1763  -21.3346
            53  C5x C    18.7715  -28.2854
            54  C1c C    21.0286  -30.2086
            55  C1y C    16.8112  -22.5652
            56  O6a O    17.9180  -24.4760
            57  C1y C    33.2913  -28.3718
            58  C1x C    32.6358  -30.3321
            59  C5x C    33.3223  -24.5317
            60  C1a C    34.4478  -22.6270
            61  C1a C    33.3655  -20.7099
            62  C1a C    31.1516  -20.6852
            63  N1y N    16.7493  -29.0583
            64  O5x O    18.7715  -26.9929
            65  C1a C    19.9217  -30.8456
            66  C1a C    22.1354  -30.8456
            67  N1y N    15.7104  -23.2022
            68  C1c C    16.8049  -21.2851
            69  C1x C    34.3178  -29.1326
            70  C5x C    33.3036  -27.0856
            71  C1x C    33.9098  -30.3445
            72  C1x C    34.4231  -25.1809
            73  O5x O    32.2153  -25.1625
            74  C1y C    15.7165  -28.3162
            75  C1x C    16.3598  -30.2765
            76  C5x C    15.6465  -24.4822
            77  C1a C    14.6034  -22.5714
            78  C1a C    17.9180  -20.6481
            79  C1a C    15.7041  -20.6481
            80  N1y N    34.4168  -26.4673
            81  O5x O    32.2092  -26.4426
            82  C1x C    14.6776  -29.0583
            83  C5x C    15.7165  -27.0361
            84  C1x C    15.0797  -30.2765
            85  C1x C    14.6034  -25.1192
            86  O5x O    16.8112  -25.1130
            87  C1a C    35.5238  -27.1165
            88  N1y N    14.6096  -26.3992
            89  O5x O    16.8112  -26.3931
            90  C1a C    13.5089  -27.0424
BOND        96
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    9  15 1
            15    9  16 2
            16   10  17 2
            17   11  18 2
            18   13  19 1
            19   13  20 1
            20   15  21 1
            21   17  22 1
            22   17  23 1
            23   20  24 1
            24   20  25 2
            25   21  26 1
            26   21  27 1
            27   24  28 1
            28   26  29 1
            29   26  30 2
            30   27  31 1
            31   27  32 1
            32   28  33 1
            33   28  34 1
            34   29  35 1
            35   31  36 1
            36   33  37 1
            37   33  38 2
            38   34  39 1
            39   34  40 1
            40   35  41 1
            41   35  42 1
            42   36  43 1
            43   36  44 2
            44   37  45 1
            45   39  46 1
            46   41  47 1
            47   41  48 2
            48   42  49 1
            49   42  50 1
            50   43  51 1
            51   43  52 1
            52   45  53 1
            53   45  54 1
            54   46  55 1
            55   46  56 2
            56   47  57 1
            57   47  58 1
            58   51  59 1
            59   51  60 1
            60   52  61 1
            61   52  62 1
            62   53  63 1
            63   53  64 2
            64   54  65 1
            65   54  66 1
            66   55  67 1
            67   55  68 1
            68   57  69 1
            69   57  70 1
            70   58  71 1
            71   59  72 1
            72   59  73 2
            73   63  74 1
            74   63  75 1
            75   67  76 1
            76   67  77 1
            77   68  78 1
            78   68  79 1
            79   70  80 1
            80   70  81 2
            81   74  82 1
            82   74  83 1
            83   75  84 1
            84   76  85 1
            85   76  86 2
            86   80  87 1
            87   83  88 1
            88   83  89 2
            89   88  90 1
            90    7  10 1
            91    8  11 1
            92   19  22 2
            93   69  71 1
            94   72  80 1
            95   82  84 1
            96   85  88 1

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