KEGG   DRUG: D00216Help
Entry
D00216                      Drug                                   

Name
Acarbose (JAN/USAN/INN);
Precose (TN)
Product
  Generic
Formula
C25H43NO18
Exact mass
645.248
Mol weight
645.6048
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Actinoplanes [TAX:1865]
Activity
Inhibitor [alpha-glucosidase] [DS:H00409]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
alpha-glucosidase inhibitor [HSA:2548 2595 8972] [KO:K12316 K12317 K12047];
alpha-amylase inhibitor [HSA:279 280] [KO:K01176]
  Pathway
hsa00052  Galactose metabolism
hsa00500  Starch and sucrose metabolism
hsa04972  Pancreatic secretion
hsa04973  Carbohydrate digestion and absorption  
 
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BF Alpha glucosidase inhibitors
     A10BF01 Acarbose
      D00216  Acarbose (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Acarbose
    D00216  Acarbose (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D00216  Acarbose (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   alpha-amylase
    Acarbose
     D00216  Acarbose (JAN/USAN/INN)
   alpha-glucosidase
    Acarbose
     D00216  Acarbose (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
56180-94-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        44
            1   C1y C    18.1630   -9.4066
            2   C1y C    18.1630  -10.8090
            3   C1y C    19.4251  -11.5102
            4   C1y C    20.6172  -10.8090
            5   C2x C    20.6172   -9.4066
            6   C2y C    19.4251   -8.7054
            7   C1b C    19.4251   -7.3031
            8   O1a O    20.6172   -6.6019
            9   O1a O    16.9709  -11.5102
            10  O1a O    19.4251  -12.9126
            11  O1a O    16.9709   -8.7054
            12  N1b N    21.8793  -11.5102
            13  C1y C    23.0713  -10.8090
            14  C1y C    24.2634  -11.5102
            15  C1y C    25.4554  -10.8090
            16  C1y C    25.4554   -9.4066
            17  O2x O    24.2634   -8.7054
            18  C1y C    23.0713   -9.4066
            19  O2a O    26.7175   -8.7054
            20  O1a O    24.2634  -12.9126
            21  O1a O    26.6474  -11.5102
            22  C1a C    21.8092   -8.7054
            23  C1y C    27.9096   -6.6019
            24  C1y C    27.9096   -8.0043
            25  C1y C    29.1016   -8.7054
            26  C1y C    30.3638   -8.0043
            27  C1y C    30.3638   -6.6019
            28  O2x O    29.1016   -5.9007
            29  C1b C    26.7175   -5.9007
            30  O1a O    29.1016  -10.1078
            31  O1a O    31.5558   -8.7054
            32  O2a O    31.5558   -5.9007
            33  O1a O    25.5255   -6.6019
            34  C1y C    32.7478   -3.7971
            35  C1y C    32.7478   -5.1995
            36  C1y C    33.9399   -5.9007
            37  C1y C    35.2020   -5.1995
            38  C1y C    35.2020   -3.7971
            39  O2x O    33.9399   -3.0959
            40  C1b C    31.5558   -3.0959
            41  O1a O    33.9399   -7.3031
            42  O1a O    36.3940   -3.0959
            43  O1a O    36.3940   -5.9007
            44  O1a O    30.3638   -3.7971
BOND        47
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   9 1 #Up
            10    3  10 1 #Down
            11    1  11 1 #Down
            12    4  12 1 #Down
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   16  19 1 #Down
            21   14  20 1 #Up
            22   15  21 1 #Down
            23   18  22 1 #Up
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   27  28 1
            29   23  28 1
            30   23  29 1 #Up
            31   25  30 1 #Up
            32   24  19 1 #Down
            33   26  31 1 #Down
            34   27  32 1 #Down
            35   29  33 1
            36   34  35 1
            37   35  36 1
            38   36  37 1
            39   37  38 1
            40   38  39 1
            41   34  39 1
            42   34  40 1 #Up
            43   36  41 1 #Up
            44   38  42 1 #Either
            45   37  43 1 #Down
            46   35  32 1 #Down
            47   40  44 1

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