KEGG   DRUG: D00225Help
Entry
D00225                      Drug                                   

Name
Alprazolam (JP16/USP/INN);
Xanax (TN)
Product
  Generic
ALPRAZOLAM (A-S Medication Solutions LLC), ALPRAZOLAM (A-S Medication Solutions LLC), ALPRAZOLAM (A-S Medication Solutions LLC), ALPRAZOLAM (Actavis Elizabeth LLC), ALPRAZOLAM (Actavis Elizabeth LLC), ALPRAZOLAM (Actavis Elizabeth LLC), ALPRAZOLAM (Aidarex Pharmaceuticals LLC), ALPRAZOLAM (Aidarex Pharmaceuticals LLC), ALPRAZOLAM (American Health Packaging), ALPRAZOLAM (American Health Packaging), ALPRAZOLAM (Amneal Pharmaceuticals), ALPRAZOLAM (Aphena Pharma Solutions - Tennessee), ALPRAZOLAM (Apotex Corp), ALPRAZOLAM (Aurobindo Pharma Limited), ALPRAZOLAM (AvKARE), ALPRAZOLAM (Blenheim Pharmacal), ALPRAZOLAM (Boca Pharmacal), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Bryant Ranch Prepack), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Cardinal Health), ALPRAZOLAM (Contract Pharmacy Services-PA), ALPRAZOLAM (Contract Pharmacy Services-PA), ALPRAZOLAM (CorePharma), ALPRAZOLAM (DAVA Pharmaceuticals), ALPRAZOLAM (Dispensing Solutions), ALPRAZOLAM (Global Pharmaceuticals), ALPRAZOLAM (Golden State Medical Supply), ALPRAZOLAM (Greenstone LLC), ALPRAZOLAM (Greenstone LLC), ALPRAZOLAM (H.J. Harkins Company), ALPRAZOLAM (KAISER FOUNDATION HOSPITALS), ALPRAZOLAM (KAISER FOUNDATION HOSPITALS), ALPRAZOLAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Lake Erie Medical DBA Quality Care Products LLC), ALPRAZOLAM (Life Line Home Care Services), ALPRAZOLAM (Major Pharmaceuticals), ALPRAZOLAM (McKesson Contract Packaging), ALPRAZOLAM (Mylan Institutional), ALPRAZOLAM (Mylan Pharmaceuticals), ALPRAZOLAM (Mylan Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (PD-Rx Pharmaceuticals), ALPRAZOLAM (Par Pharmaceutical), ALPRAZOLAM (Physicians Total Care), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Preferred Pharmaceuticals), ALPRAZOLAM (Qualitest Pharmaceuticals), ALPRAZOLAM (REMEDYREPACK), ALPRAZOLAM (Rebel Distributors Corp), ALPRAZOLAM (Rebel Distributors Corp), ALPRAZOLAM (Rebel Distributors Corp.), ALPRAZOLAM (Rebel Distributors Corp.), ALPRAZOLAM (RedPharm), ALPRAZOLAM (RedPharm Drug), ALPRAZOLAM EXTENDED-RELEASE (Rising Pharmaceuticals), ALPRAZOLAM (Roxane Laboratories), ALPRAZOLAM (STAT RX USA LLC), ALPRAZOLAM (STAT Rx USA LLC), ALPRAZOLAM (STAT Rx USA LLC), ALPRAZOLAM (Sandoz), ALPRAZOLAM (Sun Pharma Global FZE), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services), ALPRAZOLAM (Unit Dose Services)
Formula
C17H13ClN4
Exact mass
308.0829
Mol weight
308.7649
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Anxiolytics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00225  Alprazolam (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA12 Alprazolam
      D00225  Alprazolam (JP16/USP/INN)
USP drug classification [BR:br08302]
 Anxiolytics
  Benzodiazepines
   Alprazolam
    D00225  Alprazolam (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Alprazolam [ATC:N05BA12]
      D00225  Alprazolam (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
28981-97-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C2y C    11.2028  -17.3488
            2   C8y C    10.3478  -16.2505
            3   C8y C    10.6659  -14.8908
            4   N4y N    11.9188  -14.2978
            5   N2x N    12.6076  -17.3566
            6   C8y C    13.1789  -14.9040
            7   C1x C    13.4820  -16.2680
            8   C8x C     9.6478  -13.9358
            9   C8x C     8.3118  -14.3400
            10  C8y C     7.9936  -15.6997
            11  C8x C     9.0117  -16.6546
            12  C8y C    10.5740  -18.6251
            13  C8x C     9.1513  -18.6484
            14  C8x C     8.5338  -19.9703
            15  C8x C     9.3094  -21.1309
            16  C8x C    10.7341  -21.1074
            17  C8x C    11.3495  -19.7858
            18  N5x N    14.1449  -13.8929
            19  N5x N    13.4818  -12.6617
            20  C8y C    12.1059  -12.9119
            21  C1a C    11.0956  -11.9466
            22  X   Cl    6.6468  -16.1072
BOND        25
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    1  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    6  18 2
            21   18  19 1
            22   19  20 2
            23    4  20 1
            24   20  21 1
            25   10  22 1

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