| Entry |
|
|---|
| Name |
Amoxapine (JP16/USP/INN);
Asendin (TN)
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| Product |
|
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| Generic |
|
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| Formula |
C17H16ClN3O
|
|---|
| Exact mass |
313.0982
|
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| Mol weight |
313.7814
|
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| Structure |
     |
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| Activity |
Antidepressant
|
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| Remark |
Therapeutic category: ATC code: |
|---|
| Comment |
Tricyclic antidepressants
|
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| Target |
serotonin transporter inhibitor [HSA: 6532] [KO: K05037]; noradrenalin transporter inhibitor [HSA: 6530] [KO: K05035] |
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP1A2 [HSA: 1544], CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| Antidepressants | | Antipsychotics | | Neurotransmitter transporter inhibitors |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00228 Amoxapine (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA17 Amoxapine
D00228 Amoxapine (JP16/USP/INN)
USP drug classification [BR:br08302]
Antidepressants
Tricyclics
Amoxapine
D00228 Amoxapine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
Amoxapine [ATC:N06AA17]
D00228 Amoxapine (JP16/USP/INN)
 |
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| Other DBs |
CAS: 14028-44-5 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 22
1 C2y C 9.4323 -15.7409
2 C8y C 8.5912 -14.6326
3 C8y C 8.9260 -13.2774
4 O2x O 10.1856 -12.7000
5 N2x N 10.8365 -15.7661
6 C8y C 11.4377 -13.3216
7 C8y C 11.7239 -14.6887
8 C8x C 7.9201 -12.3102
9 C8x C 6.5797 -12.6978
10 C8y C 6.2449 -14.0530
11 C8x C 7.2508 -15.0200
12 C8x C 13.0535 -15.1253
13 C8x C 14.0965 -14.1920
14 C8x C 13.8104 -12.8249
15 C8x C 12.4806 -12.3883
16 X Cl 4.8817 -14.4470
17 N1y N 8.7986 -16.9892
18 C1x C 7.3986 -16.9892
19 C1x C 6.6986 -18.2016
20 N1x N 7.3986 -19.4141
21 C1x C 8.7986 -19.4141
22 C1x C 9.4986 -18.2016
BOND 25
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 10 16 1
19 1 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 17 22 1
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