KEGG   DRUG: InamrinoneHelp
Entry
D00231                      Drug                                   

Name
Inamrinone (USP);
Amrinone (JAN/INN);
Amcoral (TN)
Formula
C10H9N3O
Exact mass
187.0746
Mol weight
187.198
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01757  Amrinone type cardiotonic
 DG01507  Phosphodiesterase III inhibitor
  DG01757  Amrinone type cardiotonic
Remark
ATC code: C01CE01
Chemical structure group: DG00228
Efficacy
Cardiotonic, Phosphodiesterase 3 inhibitor
Comment
Amrinone derivative
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296]
  Pathway
hsa00230  Purine metabolism
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04371  Apelin signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CE Phosphodiesterase inhibitors
     C01CE01 Amrinone
      D00231  Inamrinone (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE3
     D00231  Inamrinone (USP)
BRITE hierarchy
Other DBs
CAS: 60719-84-8
PubChem: 7847298
ChEBI: 2686
ChEMBL: CHEMBL12856
DrugBank: DB01427
LigandBox: D00231
NIKKAJI: J17.949C
KCF data Show

ATOM        14
            1   C8y C    18.8920  -16.7926
            2   C8y C    20.1271  -16.1237
            3   C8x C    17.6932  -16.0675
            4   C8x C    18.8666  -18.1940
            5   C8x C    20.1866  -14.7238
            6   C8x C    21.3057  -16.8729
            7   C8y C    16.4687  -16.7440
            8   N4x N    17.6342  -18.8681
            9   C8x C    21.4195  -14.0760
            10  C8x C    22.6167  -16.2273
            11  C8y C    16.4406  -18.1402
            12  N1a N    15.2699  -16.0189
            13  N5x N    22.6061  -14.8276
            14  O5x O    15.2163  -18.8166
BOND        15
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 1
            12    9  13 1
            13   11  14 2
            14    8  11 1
            15   10  13 2

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