KEGG   DRUG: D00247Help
Entry
D00247                      Drug                                   

Name
Bumetanide (JP16/USP/INN);
Bumex (TN)
Product
  Generic
BUMETANIDE (Aidarex Pharmaceuticals LLC), BUMETANIDE (AvKARE), BUMETANIDE (Baxter Healthcare Corporation), BUMETANIDE (Bryant Ranch Prepack), BUMETANIDE (Cardinal Health), BUMETANIDE (Cardinal Health), BUMETANIDE (Cardinal Health), BUMETANIDE (Cardinal Health), BUMETANIDE (Cardinal Health), BUMETANIDE (Cardinal Health), BUMETANIDE (Eon Labs), BUMETANIDE (Hospira), BUMETANIDE (Hospira), BUMETANIDE (Lake Erie Medical DBA Quality Care Products LLC), BUMETANIDE (Mylan Institutional), BUMETANIDE (NCS HealthCare of KY), BUMETANIDE (Physicians Total Care), BUMETANIDE (St Marys Medical Park Pharmacy), BUMETANIDE (St Marys Medical Park Pharmacy), BUMETANIDE (Teva Pharmaceuticals USA), BUMETANIDE (Unit Dose Services), BUMETANIDE (Unit Dose Services), BUMETANIDE (West-Ward Pharmaceutical Corp.), BUMETANIDE (West-ward Pharmaceutical Corp.)
Formula
C17H20N2O5S
Exact mass
364.1093
Mol weight
364.4161
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Loop diuretics
Target
Na-K-Cl cotransporter 1 inhibitor [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 inhibitor [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A8 [HSA:9376]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA02 Bumetanide
      D00247  Bumetanide (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Bumetanide
    D00247  Bumetanide (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00247  Bumetanide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Bumetanide
      D00247  Bumetanide (JP16/USP/INN)
    SLC12A2
     Bumetanide
      D00247  Bumetanide (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00247  Bumetanide
BRITE hierarchy
Other DBs
CAS: 
28395-03-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    20.0084  -14.7933
            2   C8y C    18.8179  -15.4820
            3   C8y C    20.0027  -13.4217
            4   O2a O    21.1932  -15.4761
            5   C8x C    17.6215  -14.7933
            6   N1b N    18.8237  -16.8592
            7   C8x C    18.8120  -12.7330
            8   S4a S    21.1932  -12.7330
            9   C8y C    22.6347  -16.1998
            10  C8y C    17.6215  -13.4217
            11  C1b C    17.6272  -17.5479
            12  N1a N    22.5648  -11.8226
            13  O3c O    21.9169  -13.9061
            14  O3c O    20.4812  -11.4083
            15  C8x C    22.6347  -17.5772
            16  C8x C    23.8311  -15.5052
            17  C6a C    16.4367  -12.7273
            18  C1b C    16.4367  -16.8651
            19  C8x C    23.8311  -18.2658
            20  C8x C    25.0159  -16.1998
            21  O6a O    15.2403  -13.4217
            22  O6a O    16.4367  -11.3557
            23  C1b C    15.2460  -17.5479
            24  C8x C    25.0159  -17.5772
            25  C1a C    14.0555  -16.8651
BOND        26
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    8  12 1
            12    8  13 2
            13    8  14 2
            14    9  15 2
            15    9  16 1
            16   10  17 1
            17   11  18 1
            18   15  19 1
            19   16  20 2
            20   17  21 1
            21   17  22 2
            22   18  23 1
            23   19  24 2
            24   23  25 1
            25    7  10 2
            26   20  24 1

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