KEGG   DRUG: D00247Help
Entry
D00247                      Drug                                   

Name
Bumetanide (JP16/USP/INN);
Bumex (TN)
Product
  Generic
Formula
C17H20N2O5S
Exact mass
364.1093
Mol weight
364.4161
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Therapeutic category: 
ATC code: 
Comment
Loop diuretics
Target
Na-K-Cl cotransporter 1 inhibitor [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 inhibitor [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A8 [HSA:9376]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA02 Bumetanide
      D00247  Bumetanide (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Bumetanide
    D00247  Bumetanide (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00247  Bumetanide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Bumetanide
      D00247  Bumetanide (JP16/USP/INN)
    SLC12A2
     Bumetanide
      D00247  Bumetanide (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00247  Bumetanide
BRITE hierarchy
Other DBs
CAS: 
28395-03-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    20.0084  -14.7933
            2   C8y C    18.8179  -15.4820
            3   C8y C    20.0027  -13.4217
            4   O2a O    21.1932  -15.4761
            5   C8x C    17.6215  -14.7933
            6   N1b N    18.8237  -16.8592
            7   C8x C    18.8120  -12.7330
            8   S4a S    21.1932  -12.7330
            9   C8y C    22.6347  -16.1998
            10  C8y C    17.6215  -13.4217
            11  C1b C    17.6272  -17.5479
            12  N1a N    22.5648  -11.8226
            13  O3c O    21.9169  -13.9061
            14  O3c O    20.4812  -11.4083
            15  C8x C    22.6347  -17.5772
            16  C8x C    23.8311  -15.5052
            17  C6a C    16.4367  -12.7273
            18  C1b C    16.4367  -16.8651
            19  C8x C    23.8311  -18.2658
            20  C8x C    25.0159  -16.1998
            21  O6a O    15.2403  -13.4217
            22  O6a O    16.4367  -11.3557
            23  C1b C    15.2460  -17.5479
            24  C8x C    25.0159  -17.5772
            25  C1a C    14.0555  -16.8651
BOND        26
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    8  12 1
            12    8  13 2
            13    8  14 2
            14    9  15 2
            15    9  16 1
            16   10  17 1
            17   11  18 1
            18   15  19 1
            19   16  20 2
            20   17  21 1
            21   17  22 2
            22   18  23 1
            23   19  24 2
            24   23  25 1
            25    7  10 2
            26   20  24 1

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