KEGG   DRUG: D00251Help
Entry
D00251                      Drug                                   

Name
Captopril (JP16/USP/INN);
Apopril (TN);
Capoten (TN)
Product
  Generic
CAPTOPRIL (Aidarex Pharmaceuticals LLC), CAPTOPRIL (Apotex Corp.), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Bryant Ranch Prepack), CAPTOPRIL (Cardinal Health), CAPTOPRIL (Cardinal Health), CAPTOPRIL (Golden State Medical Supply), CAPTOPRIL (Legacy Pharmaceutical Packaging), CAPTOPRIL (Major Pharmaceuticals), CAPTOPRIL (Mylan Pharmaceuticals), CAPTOPRIL (NCS HealthCare of KY), CAPTOPRIL (PD-Rx Pharmaceuticals), CAPTOPRIL (PD-Rx Pharmaceuticals), CAPTOPRIL (Physicians Total Care), CAPTOPRIL (Preferred Pharmaceuticals), CAPTOPRIL (REMEDYREPACK), CAPTOPRIL (REMEDYREPACK), CAPTOPRIL (REMEDYREPACK), CAPTOPRIL (Rebel Distributors Corp), CAPTOPRIL (RedPharm Drug), CAPTOPRIL (RedPharm Drug), CAPTOPRIL (St Marys Medical Park Pharmacy), CAPTOPRIL (State of Florida DOH Central Pharmacy), CAPTOPRIL (State of Florida DOH Central Pharmacy), CAPTOPRIL (UDL Laboratories), CAPTOPRIL (Unit Dose Services), CAPTOPRIL (Unit Dose Services), CAPTOPRIL (Unit Dose Services), CAPTOPRIL (West-Ward Pharmaceutical Corp), CAPTOPRIL (Wockhardt Limited), CAPTOPRIL (Wockhardt USA LLC.), CAPTOPRIL (Aidarex Pharmaceuticals LLC), CAPTOPRIL (Preferred Pharmaceuticals), CAPTOPRIL (Rebel Distributors Corp)
Formula
C9H15NO3S
Exact mass
217.0773
Mol weight
217.2853
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive;
Enzyme inhibitor [angiotensin-converting]
Remark
Therapeutic category: 
ATC code: 
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Metabolism
Transporter: SLC15A1 [HSA:6564], SCL15A2 [HSA:6565], SLC22A6 [HSA:9356]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00251  Captopril (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA01 Captopril
      D00251  Captopril (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Captopril
    D00251  Captopril (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE) [HSA:1636] [KO:K01283]
    Captopril [ATC:C09AA01]
     D00251  Captopril (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
62571-86-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   C1x C    30.3001  -29.3105
            2   C1x C    30.7108  -30.6489
            3   C1x C    32.1107  -30.6718
            4   C1y C    32.5650  -29.3476
            5   N1y N    31.4460  -28.5062
            6   C5a C    31.4460  -27.1062
            7   O5a O    32.6533  -26.4091
            8   C1c C    30.2145  -26.3954
            9   C1b C    29.0237  -27.0832
            10  S1a S    27.8339  -26.3964
            11  C6a C    33.8944  -28.9394
            12  O6a O    35.2472  -29.5220
            13  O6a O    33.8637  -27.5503
            14  C1a C    30.2142  -24.9902
BOND        14
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     5   6 1
            7     6   7 2
            8     6   8 1
            9     8   9 1
            10    9  10 1
            11    4  11 1 #Down
            12   11  12 1
            13   11  13 2
            14    8  14 1 #Up

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